PMID- 25993870
OWN - NLM
STAT- MEDLINE
DCOM- 20150612
LR  - 20150521
IS  - 1682-8658 (Print)
IS  - 1682-8658 (Linking)
IP  - 2
DP  - 2015
TI  - [Irritable bowel syndrome with extraintestinal manifestations from a position of 
      neuroendocrine pathology].
PG  - 29-34
AB  - The aim of this study was to investigate the mechanism (s) of action of 
      gastrointestinal hormones in the pathogenesis of irritable bowel syndrome (IBS), 
      and the correlation between gastrointestinal hormones and psychological factors. 
      Patients with IBS were divided into IBS with normal emotional state ratings and 
      IBS in anxiety-depressive states groups. The two groups were then subdivided into 
      IBS-constipation predominant (IBS-C) and IBS-diarrhea predominant (IBS-D) groups. 
      Non-IBS patients with normal depression and anxiety ratings were recruited as 
      controls. The expression of somatostatin (SS) and vasointestinalpeptid (VIP), 
      motilin in the colonic mucosa was detected by immunohistochemistry and 
      radioimmunoassay. The anxiety-depression scores of patients with IBS were 
      significantly different from those of the control group. The expression levels of 
      SS and VIP, motilin colonic mucosa of the patients with IBS were higher compared 
      with those of the control.group. Furthermore, the expression level of SS in the 
      IBS-C group demonstrated a significantly larger increase than that in the IBS-D 
      group; however, there was no significant difference in the expression of VIP 
      between the IBS-C and IBS-D groups. In addition, the expression levels of SS and 
      VIP, motilin in the IBS groups with normal emotional state ratings were notably 
      different from those in the IBS groups in anxiety-depressive states. 
      Anxiety-depressive states may lead to changes in the secretion of SS and VIP, 
      motilin, and subsequently to changes in gastrointestinal motility and function.
FAU - Osadchuk, M A
AU  - Osadchuk MA
FAU - Burdina, V O
AU  - Burdina VO
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Eksp Klin Gastroenterol
JT  - Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical 
      gastroenterology
JID - 101144944
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 51110-01-1 (Somatostatin)
RN  - 52906-92-0 (Motilin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anxiety Disorders/*blood/complications/physiopathology
MH  - Colon/metabolism/pathology/physiopathology
MH  - Depression/*blood/complications/physiopathology
MH  - Female
MH  - Gastrointestinal Motility
MH  - Gene Expression Regulation
MH  - Humans
MH  - Intestinal Mucosa/metabolism/pathology/physiopathology
MH  - Irritable Bowel Syndrome/*blood/complications/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Motilin/*blood
MH  - Neurosecretory Systems/*metabolism/physiopathology
MH  - Somatostatin/*blood
MH  - Vasoactive Intestinal Peptide/*blood
EDAT- 2015/05/23 06:00
MHDA- 2015/06/13 06:00
CRDT- 2015/05/22 06:00
PHST- 2015/05/22 06:00 [entrez]
PHST- 2015/05/23 06:00 [pubmed]
PHST- 2015/06/13 06:00 [medline]
PST - ppublish
SO  - Eksp Klin Gastroenterol. 2015;(2):29-34.