PMID- 25993973
OWN - NLM
STAT- MEDLINE
DCOM- 20160408
LR  - 20150716
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 43
IP  - 8
DP  - 2015 Aug
TI  - Fine needle aspiration cytology of histiocytic sarcoma with dendritic cell 
      differentiation: a case of transdifferentiation from low-grade follicular 
      lymphoma.
PG  - 659-63
LID - 10.1002/dc.23285 [doi]
AB  - Histiocytic sarcoma (HS) is a rare malignant tumor, and in extraordinary 
      circumstances it can be transdifferentiated from a low-grade B-cell lymphoma. In 
      our report, a 62-year-old female was initially diagnosed with a low-grade 
      follicular lymphoma, and 2 years later she presented with bilateral lung masses 
      and lymphadenopathy. Fine needle aspiration (FNA) of the lung masses revealed 
      solid nests of large pleomorphic epithelioid cells. By immunohistochemical 
      studies, the tumor cells were positive for histiocytic markers (CD68 and CD163) 
      and S100, supporting a diagnosis of HS with dendritic cell differentiation. 
      Further fluorescence in situ hybridization (FISH) analyses detected IGH@/BCL2 
      rearrangement in both the previous follicular lymphoma and the current HS, which 
      was highly suggestive of the clonal relationship between these two tumors. To the 
      best of our knowledge, this is the first case of transformation of follicular 
      lymphoma into HS diagnosed by FNA of lung masses.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Mehrotra, Sanjana
AU  - Mehrotra S
AD  - Department of Pathology, University of Colorado School of Medicine, Aurora, 
      Colorado.
FAU - Pan, Zenggang
AU  - Pan Z
AD  - Department of Pathology, University of Colorado School of Medicine, Aurora, 
      Colorado.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150521
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CD163 antigen)
RN  - 0 (CD68 antigen, human)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Antigens, CD/metabolism
MH  - Antigens, Differentiation, Myelomonocytic/metabolism
MH  - B-Lymphocytes/metabolism/pathology
MH  - Biomarkers, Tumor/*metabolism
MH  - Biopsy, Fine-Needle
MH  - *Cell Transdifferentiation
MH  - Female
MH  - Histiocytic Sarcoma/*diagnosis/metabolism/pathology
MH  - Histocytochemistry
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lung/metabolism/pathology
MH  - Lymph Nodes/metabolism/pathology
MH  - Lymphoma, Follicular/*diagnosis/metabolism/pathology
MH  - Middle Aged
MH  - Receptors, Cell Surface/metabolism
MH  - S100 Proteins/metabolism
OTO - NOTNLM
OT  - follicular lymphoma
OT  - histiocytic sarcoma
OT  - transdifferentiation
EDAT- 2015/05/23 06:00
MHDA- 2016/04/09 06:00
CRDT- 2015/05/22 06:00
PHST- 2014/12/11 00:00 [received]
PHST- 2015/03/19 00:00 [revised]
PHST- 2015/03/30 00:00 [accepted]
PHST- 2015/05/22 06:00 [entrez]
PHST- 2015/05/23 06:00 [pubmed]
PHST- 2016/04/09 06:00 [medline]
AID - 10.1002/dc.23285 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2015 Aug;43(8):659-63. doi: 10.1002/dc.23285. Epub 2015 May 21.