PMID- 25994133
OWN - NLM
STAT- MEDLINE
DCOM- 20160208
LR  - 20150521
IS  - 1881-7742 (Electronic)
IS  - 0301-4800 (Linking)
VI  - 61
IP  - 1
DP  - 2015
TI  - Impact of exercise and vitamin B1 intake on hippocampal brain-derived 
      neurotrophic factor and spatial memory performance in a rat model of stress.
PG  - 1-7
LID - 10.3177/jnsv.61.1 [doi]
AB  - Chronic stress affects brain areas involved in learning and emotional responses 
      through modulation of neurotropic factors or neurotransmitters. Therefore, we 
      investigated the role of exercise and thiamine supplementation on spatial memory 
      and on brain-derived neurotrophic factor (BDNF) and acetylcholine (Ach) content 
      in the hippocampus of the stressed animals. Male Wistar rats were randomly 
      assigned to 4 groups (8 rats/group): control group; stress group; swimming and 
      stress group; and thiamine and stress group. All animals were assessed by a T 
      maze for spatial memory or open field test for locomotion and anxiety. BDNF and 
      Ach were estimated in the hippocampus. Chronic immobilization stress resulted in 
      a significant decrease in BDNF and Ach levels in the hippocampus and impairment 
      in spatial memory functions and decreased basal activity. However, either 
      swimming training or thiamine intake for 30 d was proved to induce a significant 
      increase both in BDNF and Ach in conjunction with improved performance in the T 
      maze, marked anxiolytic effect and enhanced ambulation in the open field test, as 
      compared to the stress group. Interestingly, swimming-exercised rats showed 
      significantly higher levels of BDNF versus thiamine-receiving rats, while 
      thiamine-receiving rats showed higher locomotor activity and less freezing 
      behavior in the open field test compared to the swimming group. It was concluded 
      that decreased BDNF and Ach after stress exposure could be a mechanism for the 
      deleterious actions of stress on memory function; swimming exercise or vitamin B1 
      supplementation for 30 d was a protective tool to improve coping with chronic 
      stress by modulating BDNF and Ach content along with enhancement of memory 
      functions and motor activities.
FAU - E Dief, Abeer
AU  - E Dief A
AD  - Medical Physiology Department, Faculty of Medicine, Alexandria University.
FAU - M Samy, Doaa
AU  - M Samy D
FAU - I Dowedar, Fatma
AU  - I Dowedar F
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - N9YNS0M02X (Acetylcholine)
RN  - X66NSO3N35 (Thiamine)
SB  - IM
MH  - Acetylcholine/metabolism
MH  - Animals
MH  - Anxiety/complications/therapy
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Hippocampus/*drug effects
MH  - Immobilization
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/etiology/*therapy
MH  - Physical Conditioning, Animal/physiology
MH  - Rats, Wistar
MH  - Spatial Memory/*drug effects
MH  - Stress, Psychological/complications/*therapy
MH  - Swimming/*physiology
MH  - Thiamine/pharmacology/*therapeutic use
MH  - Vitamin B Complex/pharmacology/therapeutic use
EDAT- 2015/05/23 06:00
MHDA- 2016/02/09 06:00
CRDT- 2015/05/22 06:00
PHST- 2015/05/22 06:00 [entrez]
PHST- 2015/05/23 06:00 [pubmed]
PHST- 2016/02/09 06:00 [medline]
AID - 10.3177/jnsv.61.1 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2015;61(1):1-7. doi: 10.3177/jnsv.61.1.