PMID- 25994135
OWN - NLM
STAT- MEDLINE
DCOM- 20160208
LR  - 20181217
IS  - 1881-7742 (Electronic)
IS  - 0301-4800 (Linking)
VI  - 61
IP  - 1
DP  - 2015
TI  - Effects of sugar-sweetened beverage intake on the development of type 2 diabetes 
      mellitus in subjects with impaired glucose tolerance: the Mihama diabetes 
      prevention study.
PG  - 14-9
LID - 10.3177/jnsv.61.14 [doi]
AB  - In Japan, the incidence of type 2 diabetes mellitus (T2DM) is increasing for 
      several reasons, including increased consumption of sugar-sweetened beverages 
      (SSBs). However, whether SSBs cause T2DM by excess of energy production resulting 
      in obesity remains unclear. Therefore, the present study was designed to evaluate 
      the effects of SSB intake on the development of T2DM in subjects with impaired 
      glucose tolerance (IGT). Ninety-three subjects (30 males and 63 females) with IGT 
      aged 40-69 y and residing in the Mihama district (southern Mie Prefecture, Japan) 
      were included in the study. The mean observational period was 3.6 y. All subjects 
      underwent the 75-g oral glucose tolerance test (OGTT) and completed a lifestyle 
      questionnaire survey related to SSB intake. OGTT results and SSB intake were 
      evaluated before and after the observational period. In addition, the correlation 
      between SSB intake and development of T2DM was investigated. Of the 93 subjects, 
      20 (21.5%) developed T2DM (T2DM group) and demonstrated a significantly high SSB 
      intake compared with the group that did not develop the disease (non-T2DM group). 
      The odds ratio for the incidence of T2DM based on SSB intake was 3.26 (95% 
      confidence interval, 1.17-9.06). The body mass index (BMI; kg/m(2)) and the 
      homeostasis model assessment for insulin resistance (HOMA-R) values was 
      significantly higher in the T2DM group than in the non-T2DM group, while the 
      insulinogenic indices were significantly lower in the former than in the latter 
      group. The sum of insulin secretion levels during OGTT was not significantly 
      different between groups. SSB intake correlated with the predisposition for 
      developing T2DM, possibly by influencing body weight, insulin resistance, and the 
      ability of the pancreatic beta cells to effectively compensate for the insulin 
      resistance.
FAU - Teshima, Nobuko
AU  - Teshima N
AD  - Division of Dietary Service, Mie University Hospital.
FAU - Shimo, Miho
AU  - Shimo M
FAU - Miyazawa, Kae
AU  - Miyazawa K
FAU - Konegawa, Sachi
AU  - Konegawa S
FAU - Matsumoto, Aki
AU  - Matsumoto A
FAU - Onishi, Yuki
AU  - Onishi Y
FAU - Sasaki, Ryoma
AU  - Sasaki R
FAU - Suzuki, Toshinari
AU  - Suzuki T
FAU - Yano, Yutaka
AU  - Yano Y
FAU - Matsumoto, Kazutaka
AU  - Matsumoto K
FAU - Yamada, Tomomi
AU  - Yamada T
FAU - Gabazza, Esteban Cesar
AU  - Gabazza EC
FAU - Takei, Yoshiyuki
AU  - Takei Y
FAU - Sumida, Yasuhiro
AU  - Sumida Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Nutr Sci Vitaminol (Tokyo)
JT  - Journal of nutritional science and vitaminology
JID - 0402640
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Sucrose)
RN  - 0 (Insulin)
RN  - 0 (Sweetening Agents)
SB  - IM
MH  - Beverages/*adverse effects
MH  - Blood Glucose/metabolism
MH  - *Body Mass Index
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/*etiology
MH  - Diet/adverse effects
MH  - Dietary Sucrose/*adverse effects
MH  - *Feeding Behavior
MH  - Female
MH  - Glucose Intolerance/blood/*complications
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin Resistance
MH  - Insulin Secretion
MH  - Insulin-Secreting Cells/metabolism
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/etiology
MH  - Odds Ratio
MH  - Surveys and Questionnaires
MH  - Sweetening Agents/adverse effects
EDAT- 2015/05/23 06:00
MHDA- 2016/02/09 06:00
CRDT- 2015/05/22 06:00
PHST- 2015/05/22 06:00 [entrez]
PHST- 2015/05/23 06:00 [pubmed]
PHST- 2016/02/09 06:00 [medline]
AID - 10.3177/jnsv.61.14 [doi]
PST - ppublish
SO  - J Nutr Sci Vitaminol (Tokyo). 2015;61(1):14-9. doi: 10.3177/jnsv.61.14.