PMID- 25997441
OWN - NLM
STAT- MEDLINE
DCOM- 20160524
LR  - 20181113
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 12
IP  - 3
DP  - 2015 Sep
TI  - Identification of genes associated with laryngeal squamous cell carcinoma samples 
      based on bioinformatic analysis.
PG  - 3386-3392
LID - 10.3892/mmr.2015.3794 [doi]
AB  - The present study aimed to investigate the differentially expressed genes (DEGs) 
      between laryngeal squamous cell carcinoma (LSCC) samples and non‑neoplastic 
      laryngeal squamous cell samples, and the underlying biological mechanism. Gene 
      expression profile data of GSE51985 and GSE10288 were obtained from the Gene 
      Expression Omnibus database. The DEGs between the LSCC and normal samples were 
      identified using the rowtest function in the genefilter package. Hierarchical 
      clustering for DEGs was performed to confirm the distinction between the 
      identified DEGs, and Gene Ontology term and pathway enrichment analyses were 
      performed to determine the underlying function of the DEGs. In addition, 
      protein‑protein interaction networks were established to investigate the 
      interactive mechanism of the DEGs. A total of 1,288 upregulated genes and 317 
      downregulated genes were identified between the LSCC samples and non‑neoplastic 
      LSC samples in the GSE51985 dataset, and five upregulated and 26 downregulated 
      genes were identified in the samples from the GSE10288 dataset. The DEGs were 
      clearly distinguished between the LSCC sample and the non‑neoplastic LSCC sample 
      by hierarchical clustering. The upregulated genes were predominantly involved in 
      the cell cycle, cell division or focal adhesion, and the 295 upregulated genes 
      formed 374 protein interaction pairs in interaction network analysis. The results 
      revealed that the genes involved in the cell cycle, in cell division or in focal 
      adhesion were associated with the development and progression of LSCC.
FAU - Yang, Bo
AU  - Yang B
AD  - Department of Otolaryngology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, 
      P.R. China.
FAU - Bao, Xueli
AU  - Bao X
AD  - Department of Otolaryngology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20150518
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Ontology
MH  - Gene Regulatory Networks
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Squamous Cell/*genetics/metabolism/secondary
MH  - *Transcriptome
PMC - PMC4526082
EDAT- 2015/05/23 06:00
MHDA- 2016/05/25 06:00
PMCR- 2015/05/18
CRDT- 2015/05/23 06:00
PHST- 2014/07/24 00:00 [received]
PHST- 2015/04/10 00:00 [accepted]
PHST- 2015/05/23 06:00 [entrez]
PHST- 2015/05/23 06:00 [pubmed]
PHST- 2016/05/25 06:00 [medline]
PHST- 2015/05/18 00:00 [pmc-release]
AID - mmr-12-03-3386 [pii]
AID - 10.3892/mmr.2015.3794 [doi]
PST - ppublish
SO  - Mol Med Rep. 2015 Sep;12(3):3386-3392. doi: 10.3892/mmr.2015.3794. Epub 2015 May 
      18.