PMID- 25998033
OWN - NLM
STAT- MEDLINE
DCOM- 20160602
LR  - 20220318
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 132
IP  - 1
DP  - 2015
TI  - The Effects of Oxygen Therapy on Myocardial Salvage in ST Elevation Myocardial 
      Infarction Treated with Acute Percutaneous Coronary Intervention: The 
      Supplemental Oxygen in Catheterized Coronary Emergency Reperfusion (SOCCER) 
      Study.
PG  - 16-21
LID - 10.1159/000398786 [doi]
AB  - OBJECTIVES: Despite a lack of scientific evidence, oxygen has long been a part of 
      standard treatment for patients with acute myocardial infarction (AMI). However, 
      several studies suggest that oxygen therapy may have negative cardiovascular 
      effects. We here describe a randomized controlled trial, i.e. Supplemental Oxygen 
      in Catheterized Coronary Emergency Reperfusion (SOCCER), aiming to evaluate the 
      effect of oxygen therapy on myocardial salvage and infarct size in patients with 
      ST elevation myocardial infarction (STEMI) treated with a primary percutaneous 
      coronary intervention (PCI). METHODS: One hundred normoxic STEMI patients 
      accepted for a primary PCI are randomized in the ambulance to either standard 
      oxygen therapy or no supplemental oxygen. All patients undergo cardiovascular 
      magnetic resonance imaging (CMR) 2-6 days after the primary PCI, and a subgroup 
      of 50 patients undergo an extended echocardiography during admission and at 6 
      months. All patients are followed for 6 months for hospital admission for heart 
      failure and subjective perception of health. The primary endpoint is the 
      myocardial salvage index on CMR. DISCUSSION: Even though oxygen therapy is a part 
      of standard care, oxygen may not be beneficial for patients with AMI and is 
      possibly even harmful. The results of the present and concurrent oxygen trials 
      may change international treatment guidelines for patients with AMI or ischemia.
FAU - Khoshnood, Ardavan
AU  - Khoshnood A
AD  - Section of Emergency Medicine, Clinical Sciences Lund, Lund University, Lund, 
      Sweden.
FAU - Carlsson, Marcus
AU  - Carlsson M
FAU - Akbarzadeh, Mahin
AU  - Akbarzadeh M
FAU - Bhiladvala, Pallonji
AU  - Bhiladvala P
FAU - Roijer, Anders
AU  - Roijer A
FAU - Bodetoft, Stefan
AU  - Bodetoft S
FAU - Hoglund, Peter
AU  - Hoglund P
FAU - Zughaft, David
AU  - Zughaft D
FAU - Todorova, Lizbet
AU  - Todorova L
FAU - Erlinge, David
AU  - Erlinge D
FAU - Ekelund, Ulf
AU  - Ekelund U
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150520
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Angioplasty, Balloon, Coronary/*methods
MH  - Electrocardiography
MH  - Emergencies
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Myocardial Infarction/*therapy
MH  - Myocardium/*pathology
MH  - Oxygen/*therapeutic use
MH  - Percutaneous Coronary Intervention/*adverse effects
EDAT- 2015/05/23 06:00
MHDA- 2016/06/03 06:00
CRDT- 2015/05/23 06:00
PHST- 2014/11/29 00:00 [received]
PHST- 2015/04/01 00:00 [accepted]
PHST- 2015/05/23 06:00 [entrez]
PHST- 2015/05/23 06:00 [pubmed]
PHST- 2016/06/03 06:00 [medline]
AID - 000398786 [pii]
AID - 10.1159/000398786 [doi]
PST - ppublish
SO  - Cardiology. 2015;132(1):16-21. doi: 10.1159/000398786. Epub 2015 May 20.