PMID- 25998323
OWN - NLM
STAT- MEDLINE
DCOM- 20150909
LR  - 20150610
IS  - 1879-0852 (Electronic)
IS  - 0959-8049 (Linking)
VI  - 51
IP  - 11
DP  - 2015 Jul
TI  - Adverse events of local treatment in long-term head and neck rhabdomyosarcoma 
      survivors after external beam radiotherapy or AMORE treatment.
PG  - 1424-34
LID - S0959-8049(15)00210-5 [pii]
LID - 10.1016/j.ejca.2015.02.010 [doi]
AB  - BACKGROUND: Radiotherapy is a well-known cause of adverse events (AEs). To reduce 
      AEs, an innovative local treatment was developed in Amsterdam: Ablative surgery, 
      MOuld brachytherapy and surgical REconstruction (AMORE). AIMS: (1) to determine 
      the prevalence of AEs in HNRMS survivors and (2) to compare AEs between survivors 
      treated with the international standard: external beam radiotherapy (EBRT-based: 
      London) and survivors treated with AMORE if feasible, otherwise EBRT 
      (AMORE-based: Amsterdam). METHODS: All HNRMS survivors, treated in London or 
      Amsterdam between January 1990 and December 2010 (n = 153), and alive ⩾ 2 years 
      post-treatment were eligible (n = 113). A predefined list of AEs was assessed in 
      a multidisciplinary clinic and graded according to the Common Terminology 
      Criteria for Adverse Events. RESULTS: Eighty HNRMS survivors attended the clinic 
      (median follow-up 10.5 years); 63% experienced ⩾ 1 severe or disabling event, and 
      76% had ⩾ 5 AEs (any grade). Survivors with EBRT-based treatment were, after 
      adjustment for site, age at diagnosis, and follow-up duration, at increased risk 
      to develop any grade 3/4 event or ⩾ 5 AEs (any grade) compared with survivors 
      with AMORE-based treatments (p = 0.032 and 0.01, respectively). Five year overall 
      survival (source population) after EBRT-based treatment was 75.0%, after 
      AMORE-based treatment 76.9%, p = 0.56. CONCLUSION: This study may serve as a 
      baseline inventory and can be used in future studies for prospective assessments 
      of AEs following the introduction of novel local treatment modalities. 
      AMORE-based local treatment resulted in similar overall survival and a reduction 
      of AEs secondary to local treatment.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Schoot, Reineke A
AU  - Schoot RA
AD  - Department of Paediatric Oncology, Emma Children's Hospital, Academic Medical 
      Centre, Amsterdam, The Netherlands.
FAU - Slater, Olga
AU  - Slater O
AD  - Department of Paediatric Oncology, Great Ormond Street Hospital for Children NHS 
      Foundation Trust, London, United Kingdom.
FAU - Ronckers, Cecile M
AU  - Ronckers CM
AD  - Department of Paediatric Oncology, Emma Children's Hospital, Academic Medical 
      Centre, Amsterdam, The Netherlands.
FAU - Zwinderman, Aeilko H
AU  - Zwinderman AH
AD  - Department of Clinical Epidemiology and Bio-Statistics, Academic Medical Centre, 
      Amsterdam, The Netherlands.
FAU - Balm, Alfons J M
AU  - Balm AJ
AD  - Department of Head and Neck Oncology and Surgery, The Netherlands Cancer 
      Institute, Amsterdam, The Netherlands; Department of Oral and Maxillofacial 
      surgery, Academic Medical Centre, Amsterdam, The Netherlands.
FAU - Hartley, Benjamin
AU  - Hartley B
AD  - Department of Otorhinolaryngology, Great Ormond Street Hospital for Children NHS 
      Foundation Trust, London, United Kingdom.
FAU - van den Brekel, Michiel W
AU  - van den Brekel MW
AD  - Department of Head and Neck Oncology and Surgery, The Netherlands Cancer 
      Institute, Amsterdam, The Netherlands; Department of Oral and Maxillofacial 
      surgery, Academic Medical Centre, Amsterdam, The Netherlands.
FAU - Gupta, Sanjeev
AU  - Gupta S
AD  - Department of Otorhinolaryngology, Great Ormond Street Hospital for Children NHS 
      Foundation Trust, London, United Kingdom.
FAU - Saeed, Peerooz
AU  - Saeed P
AD  - Orbital centre, Department of Ophthalmology, Academic Medical Centre, Amsterdam, 
      The Netherlands.
FAU - Gajdosova, Eva
AU  - Gajdosova E
AD  - Department of Ophthalmology, Great Ormond Street Hospital for Children NHS 
      Foundation Trust, London, United Kingdom.
FAU - Pieters, Bradley R
AU  - Pieters BR
AD  - Department of Radiation Oncology, Academic Medical Centre, Amsterdam, The 
      Netherlands.
FAU - Gaze, Mark N
AU  - Gaze MN
AD  - Department of Oncology, University College London Hospitals NHS Foundation Trust, 
      London, United Kingdom.
FAU - Mandeville, Henry C
AU  - Mandeville HC
AD  - Department of Radiotherapy, The Royal Marsden NHS Foundation Trust, Sutton, 
      United Kingdom.
FAU - Fajardo, Raquel Davila
AU  - Fajardo RD
AD  - Department of Radiation Oncology, Academic Medical Centre, Amsterdam, The 
      Netherlands.
FAU - Chang, Yen Ch'ing
AU  - Chang YC
AD  - Department of Oncology, University College London Hospitals NHS Foundation Trust, 
      London, United Kingdom.
FAU - Gains, Jennifer E
AU  - Gains JE
AD  - Department of Oncology, University College London Hospitals NHS Foundation Trust, 
      London, United Kingdom.
FAU - Strackee, Simon D
AU  - Strackee SD
AD  - Department of Plastic, Reconstructive and Hand Surgery, Academic Medical Centre, 
      Amsterdam, The Netherlands.
FAU - Dunaway, David
AU  - Dunaway D
AD  - Craniofacial Unit, Great Ormond Street Hospital for Children NHS Foundation 
      Trust, London, United Kingdom.
FAU - Abela, Christopher
AU  - Abela C
AD  - Craniofacial Unit, Great Ormond Street Hospital for Children NHS Foundation 
      Trust, London, United Kingdom.
FAU - Mason, Carol
AU  - Mason C
AD  - Dental and Maxillofacial department, Great Ormond Street Hospital for Children 
      NHS Foundation Trust, London, United Kingdom.
FAU - Smeele, Ludi E
AU  - Smeele LE
AD  - Department of Head and Neck Oncology and Surgery, The Netherlands Cancer 
      Institute, Amsterdam, The Netherlands; Department of Oral and Maxillofacial 
      surgery, Academic Medical Centre, Amsterdam, The Netherlands.
FAU - Chisholm, Julia C
AU  - Chisholm JC
AD  - Children and Young People's Department, The Royal Marsden NHS Foundation Trust, 
      Sutton, United Kingdom.
FAU - Levitt, Gill A
AU  - Levitt GA
AD  - Department of Paediatric Oncology, Great Ormond Street Hospital for Children NHS 
      Foundation Trust, London, United Kingdom.
FAU - Kremer, Leontien C M
AU  - Kremer LC
AD  - Department of Paediatric Oncology, Emma Children's Hospital, Academic Medical 
      Centre, Amsterdam, The Netherlands.
FAU - Grootenhuis, Martha A
AU  - Grootenhuis MA
AD  - Paediatric Psychosocial Department, Emma Children's Hospital, Academic Medical 
      Centre, Amsterdam, The Netherlands.
FAU - Maurice-Stam, Heleen
AU  - Maurice-Stam H
AD  - Paediatric Psychosocial Department, Emma Children's Hospital, Academic Medical 
      Centre, Amsterdam, The Netherlands.
FAU - Stiller, Charles A
AU  - Stiller CA
AD  - The Childhood Cancer Research Group, Department of Paediatrics, University of 
      Oxford, Oxford, United Kingdom.
FAU - Hammond, Peter
AU  - Hammond P
AD  - Molecular Medicine Unit, UCL Institute of Child Health, London, United Kingdom.
FAU - Caron, Huib N
AU  - Caron HN
AD  - Department of Paediatric Oncology, Emma Children's Hospital, Academic Medical 
      Centre, Amsterdam, The Netherlands.
FAU - Merks, Johannes H M
AU  - Merks JH
AD  - Department of Paediatric Oncology, Emma Children's Hospital, Academic Medical 
      Centre, Amsterdam, The Netherlands. Electronic address: j.h.merks@amc.uva.nl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150518
PL  - England
TA  - Eur J Cancer
JT  - European journal of cancer (Oxford, England : 1990)
JID - 9005373
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brachytherapy/adverse effects/methods
MH  - Child
MH  - Female
MH  - Follow-Up Studies
MH  - Head and Neck Neoplasms/*radiotherapy/*surgery
MH  - Humans
MH  - Male
MH  - Quality of Life
MH  - Radiotherapy Dosage
MH  - Radiotherapy, Conformal/adverse effects/methods
MH  - Rhabdomyosarcoma/*radiotherapy/*surgery
MH  - Survivors
MH  - Young Adult
OTO - NOTNLM
OT  - Adverse events
OT  - Brachytherapy
OT  - Head and neck
OT  - Paediatric oncology
OT  - Quality of life
OT  - Radiotherapy
OT  - Rhabdomyosarcoma
EDAT- 2015/05/23 06:00
MHDA- 2015/09/10 06:00
CRDT- 2015/05/23 06:00
PHST- 2014/12/25 00:00 [received]
PHST- 2015/02/10 00:00 [revised]
PHST- 2015/02/21 00:00 [accepted]
PHST- 2015/05/23 06:00 [entrez]
PHST- 2015/05/23 06:00 [pubmed]
PHST- 2015/09/10 06:00 [medline]
AID - S0959-8049(15)00210-5 [pii]
AID - 10.1016/j.ejca.2015.02.010 [doi]
PST - ppublish
SO  - Eur J Cancer. 2015 Jul;51(11):1424-34. doi: 10.1016/j.ejca.2015.02.010. Epub 2015 
      May 18.