PMID- 25998469
OWN - NLM
STAT- MEDLINE
DCOM- 20170327
LR  - 20170327
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 17
IP  - 5
DP  - 2016 Aug
TI  - Analysis of insulin pump settings in children and adolescents with type 1 
      diabetes mellitus.
PG  - 319-26
LID - 10.1111/pedi.12285 [doi]
AB  - AIM: To characterize current insulin pump settings used in young patients with 
      type 1 diabetes mellitus (T1DM) and to assess their relationship to glycemic 
      control. METHODS: This retrospective study included patients aged <18 yr old with 
      T1DM >1 yr using a Medtronic pump device. Pump data including number of blood 
      glucose (BG) tests per day, basal and bolus insulin parameters, carbohydrate 
      ratio (CR), and insulin sensitivity factors (ISFs) were averaged over 14 d for 
      statistical analyses. Anthropometric data and recent glycosylated hemoglobin A1c 
      (HbA1c) were recorded. RESULTS: A total of 292 patients (144 males and 148 
      females) were included in the study. Participants had a median age (interquartile 
      range, IQR) of 12.9 yr (10.0-15.1 yr) and pump duration of 2.8 yr (1.5-4.2 yr). 
      No significant differences in median HbA1c (IQR) were observed in preschool [n = 
      14; HbA1c 7.8% (7.3-8.3%)], prepubertal [n = 105; HbA1c 8.1% (7.7-8.9%)], and 
      adolescent subjects [n = 173; HbA1c 8.4% (7.7-9.0%)]. Adolescents took 
      significantly fewer boluses and BG tests per day compared with younger children 
      (p < 0.05). Age-specific diurnal variation in basal insulin delivery was noted. 
      Additionally, stronger carbohydrate cover and weaker corrections were used in 
      real-life compared with theoretical 500 and 100 rules, respectively. Lower HbA1c 
      was associated with higher number of daily boluses, greater number of BG tests 
      per day, lower average CR/500 rule ratio, and higher average ISF/100 rule ratio 
      adjusted for age (R(2) = 0.22; p < 0.01). CONCLUSION: Insulin pump therapy 
      requires continuous adjustments and glycemic targets are achieved by a minority. 
      We believe this is the first study in pediatric cohort looking at association 
      between CR and ISF with glycemic control.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Lau, Yu Ning
AU  - Lau YN
AD  - Pharmacy Department, University of Sydney, Sydney, Australia.
FAU - Korula, Sophy
AU  - Korula S
AD  - Insitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, 
      Sydney, Australia.
FAU - Chan, Albert K
AU  - Chan AK
AD  - Insitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, 
      Sydney, Australia.
FAU - Heels, Kristine
AU  - Heels K
AD  - Insitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, 
      Sydney, Australia.
FAU - Krass, Ines
AU  - Krass I
AD  - Pharmacy Department, University of Sydney, Sydney, Australia.
FAU - Ambler, Geoffrey
AU  - Ambler G
AD  - Insitute of Endocrinology and Diabetes, The Children's Hospital at Westmead, 
      Sydney, Australia.
LA  - eng
PT  - Journal Article
DEP - 20150522
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - *Blood Glucose
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*drug therapy
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage
MH  - *Infusion Pumps, Implantable
MH  - Insulin/*administration & dosage
MH  - Male
MH  - Retrospective Studies
OTO - NOTNLM
OT  - HbA1c
OT  - carbohydrate ratio
OT  - diabetes
OT  - insulin pump
EDAT- 2015/05/23 06:00
MHDA- 2017/03/28 06:00
CRDT- 2015/05/23 06:00
PHST- 2014/09/27 00:00 [received]
PHST- 2015/04/23 00:00 [revised]
PHST- 2015/04/28 00:00 [accepted]
PHST- 2015/05/23 06:00 [entrez]
PHST- 2015/05/23 06:00 [pubmed]
PHST- 2017/03/28 06:00 [medline]
AID - 10.1111/pedi.12285 [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2016 Aug;17(5):319-26. doi: 10.1111/pedi.12285. Epub 2015 May 
      22.