PMID- 25999040 OWN - NLM STAT- MEDLINE DCOM- 20160502 LR - 20181113 IS - 1573-2509 (Electronic) IS - 0920-9964 (Print) IS - 0920-9964 (Linking) VI - 166 IP - 1-3 DP - 2015 Aug TI - Demographic correlates of attenuated positive psychotic symptoms. PG - 31-6 LID - S0920-9964(15)00230-3 [pii] LID - 10.1016/j.schres.2015.04.035 [doi] AB - It is now well established that the utilization of standardized clinical criteria can enhance prediction of psychosis. These criteria are primarily concerned with the presence and severity of attenuated positive symptoms. Because these symptom criteria are used to derive algorithms for designating clinical high risk (CHR) status and for maximizing prediction of psychosis risk, it is important to know whether the symptom ratings vary as a function of demographic factors that have previously been linked with symptoms in diagnosed psychotic patients. Using a sample of 356 CHR individuals from the NAPLS-II multi-site study, we examined the relation of three sex, age, and educational level, with the severity of attenuated positive symptom scores from the Scale of Prodromal Symptoms (SOPS). Demographic factors accounted for little of the variance in symptom ratings (5-6%). Older CHR individuals manifested more severe suspiciousness, and female CHR participants reported more unusual perceptual experiences than male participants. Contrary to prediction, higher educational level was associated with more severe ratings of unusual thought content, but less severe perceptual abnormalities. Overall, sex, age and education were modestly related to unusual thought content and perceptual abnormalities, only, suggesting minimal implication for designating CHR status and predicting psychosis-risk. CI - Copyright (c) 2015 Elsevier B.V. All rights reserved. FAU - Waford, Rachel N AU - Waford RN AD - Emory University, Atlanta, GA 30322, USA. Electronic address: rwaford@emory.edu. FAU - MacDonald, Allison AU - MacDonald A AD - Emory University, Atlanta, GA 30322, USA. FAU - Goines, Katrina AU - Goines K AD - Emory University, Atlanta, GA 30322, USA. FAU - Novacek, Derek M AU - Novacek DM AD - Emory University, Atlanta, GA 30322, USA. FAU - Trotman, Hanan D AU - Trotman HD AD - Emory University, Atlanta, GA 30322, USA. FAU - Elaine F, Walker AU - Elaine F W AD - Emory University, Atlanta, GA 30322, USA. FAU - Addington, Jean AU - Addington J AD - University of Calgary, Calgary, Alberta, Canada. FAU - Bearden, Carrie E AU - Bearden CE AD - University of California, Los Angeles, Los Angeles, CA, USA. FAU - Cadenhead, Kristin S AU - Cadenhead KS AD - University of California, San Diego, San Diego, CA, USA. FAU - Cannon, Tyrone D AU - Cannon TD AD - Yale University, New Haven, CT, USA. FAU - Cornblatt, Barbara A AU - Cornblatt BA AD - Zucker Hillside Hospital, Great Neck, NY, USA. FAU - Heinssen, Robert AU - Heinssen R AD - National Institute of Mental Health, Bethesda, MD, USA. FAU - Mathalon, Daniel H AU - Mathalon DH AD - University of California, San Francisco, San Francisco, CA, USA. FAU - Tsuang, Ming T AU - Tsuang MT AD - University of California, San Diego, San Diego, CA, USA. FAU - Perkins, Diana O AU - Perkins DO AD - University of North Carolina, Chapel Hill, Chapel Hill, NC, USA. FAU - Seidman, Larry J AU - Seidman LJ AD - Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. FAU - Woods, Scott W AU - Woods SW AD - Yale University, New Haven, CT, USA. FAU - McGlashan, Thomas H AU - McGlashan TH AD - Yale University, New Haven, CT, USA. LA - eng GR - U01MH082004-01A1/MH/NIMH NIH HHS/United States GR - MH081902/MH/NIMH NIH HHS/United States GR - U01 MH082022/MH/NIMH NIH HHS/United States GR - U01 MH081984/MH/NIMH NIH HHS/United States GR - UO1 MH081857-05/MH/NIMH NIH HHS/United States GR - U01 MH081902/MH/NIMH NIH HHS/United States GR - K24MH76191/MH/NIMH NIH HHS/United States GR - P50 MH080272/MH/NIMH NIH HHS/United States GR - U01MH082022/MH/NIMH NIH HHS/United States GR - U01MH081928/MH/NIMH NIH HHS/United States GR - U01 MH081988/MH/NIMH NIH HHS/United States GR - R01MH60720/MH/NIMH NIH HHS/United States GR - P50 MH066286/MH/NIMH NIH HHS/United States GR - U01MH081988/MH/NIMH NIH HHS/United States GR - U01 MH076989/MH/NIMH NIH HHS/United States GR - K24 MH076191/MH/NIMH NIH HHS/United States GR - SCDMH82101008006/PHS HHS/United States GR - U01MH081984/MH/NIMH NIH HHS/United States GR - R01 MH060720/MH/NIMH NIH HHS/United States GR - U01 MH081928/MH/NIMH NIH HHS/United States GR - U01 MH081857/MH/NIMH NIH HHS/United States GR - U01 MH082004/MH/NIMH NIH HHS/United States GR - U01 MH081944/MH/NIMH NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural DEP - 20150518 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adolescent MH - Adult MH - Age Factors MH - Child MH - Educational Status MH - Female MH - Humans MH - Logistic Models MH - Longitudinal Studies MH - Male MH - Prodromal Symptoms MH - Psychiatric Status Rating Scales MH - Psychotic Disorders/*epidemiology/*psychology MH - Sex Factors MH - Young Adult PMC - PMC4767147 MID - NIHMS688960 OTO - NOTNLM OT - Early identification OT - Education OT - Prodrome OT - Psychosis OT - Sex COIS- Conflict of interest Dr. Bearden reports no biomedical financial interests or potential conflicts of interest. Dr. Cadenhead no biomedical financial interests or potential conflicts of interests to report. Ms. Goines reports no biomedical financial interests or potential conflicts of interest. Dr. Heinssen reports no biomedical financial interests or potential conflicts of interest. Ms. Macdonald reports no biomedical financial interests or potential conflicts of interest. Mr. Novacek reports no biomedical financial interests or potential conflicts of interest. Dr. Trotman reports no biomedical financial interests or potential conflicts of interest. Dr. Waford reports no biomedical financial interests or potential conflicts of interest. Dr. Walker reports no biomedical financial interests or potential conflicts of interest. EDAT- 2015/05/23 06:00 MHDA- 2016/05/03 06:00 PMCR- 2016/08/01 CRDT- 2015/05/23 06:00 PHST- 2015/01/15 00:00 [received] PHST- 2015/04/22 00:00 [revised] PHST- 2015/04/27 00:00 [accepted] PHST- 2015/05/23 06:00 [entrez] PHST- 2015/05/23 06:00 [pubmed] PHST- 2016/05/03 06:00 [medline] PHST- 2016/08/01 00:00 [pmc-release] AID - S0920-9964(15)00230-3 [pii] AID - 10.1016/j.schres.2015.04.035 [doi] PST - ppublish SO - Schizophr Res. 2015 Aug;166(1-3):31-6. doi: 10.1016/j.schres.2015.04.035. Epub 2015 May 18.