PMID- 25999945
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150522
LR  - 20181113
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 6
DP  - 2015
TI  - Fate mapping of dendritic cells.
PG  - 199
LID - 10.3389/fimmu.2015.00199 [doi]
LID - 199
AB  - Dendritic cells (DCs) are a heterogeneous group of mononuclear phagocytes with 
      versatile roles in immunity. They are classified predominantly based on 
      phenotypic and functional properties, namely their stellate morphology, 
      expression of the integrin CD11c, and major histocompatibility class II 
      molecules, as well as their superior capacity to migrate to secondary lymphoid 
      organs and stimulate naive T cells. However, these attributes are not exclusive 
      to DCs and often change within inflammatory or infectious environments. This led 
      to debates over cell identification and questioned even the mere existence of DCs 
      as distinct leukocyte lineage. Here, we review experimental approaches taken to 
      fate map DCs and discuss how these have shaped our understanding of DC ontogeny 
      and lineage affiliation. Considering the ontogenetic properties of DCs will help 
      to overcome the inherent shortcomings of purely phenotypic- and function-based 
      approaches to cell definition and will yield a more robust way of DC 
      classification.
FAU - Poltorak, Mateusz Pawel
AU  - Poltorak MP
AD  - Institute for Medical Microbiology, Immunology and Hygiene, Technische 
      Universitat Munchen , Munich , Germany.
FAU - Schraml, Barbara Ursula
AU  - Schraml BU
AD  - Institute for Medical Microbiology, Immunology and Hygiene, Technische 
      Universitat Munchen , Munich , Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150504
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4418393
OTO - NOTNLM
OT  - dendritic cell
OT  - fate mapping
OT  - lineage tracing
OT  - mononuclear phagocyte
OT  - ontogeny
EDAT- 2015/05/23 06:00
MHDA- 2015/05/23 06:01
PMCR- 2015/01/01
CRDT- 2015/05/23 06:00
PHST- 2015/01/31 00:00 [received]
PHST- 2015/04/13 00:00 [accepted]
PHST- 2015/05/23 06:00 [entrez]
PHST- 2015/05/23 06:00 [pubmed]
PHST- 2015/05/23 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2015.00199 [doi]
PST - epublish
SO  - Front Immunol. 2015 May 4;6:199. doi: 10.3389/fimmu.2015.00199. eCollection 2015.