PMID- 26000125
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150522
LR  - 20231111
IS  - 2038-0305 (Print)
IS  - 2038-3274 (Electronic)
IS  - 2038-0305 (Linking)
VI  - 3
IP  - 1
DP  - 2012 Apr
TI  - Routine use of Zenit RA, a novel chemiluminescent immunoanalyzer in autoimmune 
      disease diagnosis.
PG  - 27-31
LID - 10.1007/s13317-012-0032-5 [doi]
AB  - The detection of antibodies is useful to diagnose and/or to classify autoimmune 
      diseases as connective tissue diseases and vasculitis. Zenit RA is a fully 
      automated immunoanalyzer. The aim of this study was to compare the predictive and 
      discriminative performance of the Zenit RA anti-cyclic citrullinated peptide 
      (CCP), anti-cardiolipin (aCL) and anti-beta 2 glycoprotein 1 (aB2GP1) tests to 
      conventional ELISAs on clinically well-defined groups of patients and to daily 
      evaluate the determination of anti-extractable nuclear antigen (ENA), anti-double 
      stranded DNA (dsDNA), anti-myeloperoxidase (MPO) and anti-proteinase 3 (PR3) 
      antibodies in a hospital laboratory. Reagents available on Zenit RA analyzer 
      exhibit good diagnostic performances, regarding sensitivity, specificity, 
      positive and negative predictive values. Global agreements between Zenit RA and 
      conventional tests were from 90 to 98 % (Kappa-values ranging 0.56-0.94): 96 % 
      for anti-CCP, 90-94 % for aCL and aB2GP1, 94 % for anti-dsDNA, 97 % for anti-ENA, 
      98 % for anti-MPO and 95 % for anti-PR3 antibodies. Zenit RA analyzer is easy to 
      rapidly detect the most common autoantibodies in autoimmune diseases. This system 
      has a potential to provide clinically useful data within a short time. Because of 
      the flexibility of its work modalities, it is well adapted to determine antigenic 
      specificities in daily practice.
FAU - Ghillani, P
AU  - Ghillani P
AD  - Department of Immunology, Groupe Hospitalier Pitie-Salpetriere, Assistance 
      Publique-Hopitaux de Paris, Paris, France ; Laboratoire d'Immunochimie, 
      Departement d'Immunologie, Groupe Hospitalier Pitie-Salpetriere, 83 bld de 
      l'Hopital, 75013 Paris, France.
FAU - Dufat, L
AU  - Dufat L
AD  - Department of Immunology, Groupe Hospitalier Pitie-Salpetriere, Assistance 
      Publique-Hopitaux de Paris, Paris, France.
FAU - Himeur, S
AU  - Himeur S
AD  - Department of Immunology, Groupe Hospitalier Pitie-Salpetriere, Assistance 
      Publique-Hopitaux de Paris, Paris, France.
FAU - Miyara, M
AU  - Miyara M
AD  - Department of Immunology, Groupe Hospitalier Pitie-Salpetriere, Assistance 
      Publique-Hopitaux de Paris, Paris, France.
FAU - Amoura, Z
AU  - Amoura Z
AD  - Department of Internal Medicine, Groupe Hospitalier Pitie-Salpetriere, Assistance 
      Publique-Hopitaux de Paris, Paris, France.
FAU - Musset, L
AU  - Musset L
AD  - Department of Immunology, Groupe Hospitalier Pitie-Salpetriere, Assistance 
      Publique-Hopitaux de Paris, Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20120321
PL  - England
TA  - Auto Immun Highlights
JT  - Auto- immunity highlights
JID - 101532391
PMC - PMC4389018
OTO - NOTNLM
OT  - Anti-CCP antibodies
OT  - Antibody screening
OT  - Antiphospholipid antibodies
OT  - Autoimmune diseases
OT  - Zenit RA chemiluminescent analyzer
EDAT- 2012/04/01 00:00
MHDA- 2012/04/01 00:01
PMCR- 2012/03/21
CRDT- 2015/05/23 06:00
PHST- 2011/09/26 00:00 [received]
PHST- 2012/03/09 00:00 [accepted]
PHST- 2015/05/23 06:00 [entrez]
PHST- 2012/04/01 00:00 [pubmed]
PHST- 2012/04/01 00:01 [medline]
PHST- 2012/03/21 00:00 [pmc-release]
AID - 32 [pii]
AID - 10.1007/s13317-012-0032-5 [doi]
PST - epublish
SO  - Auto Immun Highlights. 2012 Mar 21;3(1):27-31. doi: 10.1007/s13317-012-0032-5. 
      eCollection 2012 Apr.