PMID- 26000149 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150522 LR - 20200930 IS - 2038-0305 (Print) IS - 2038-3274 (Electronic) IS - 2038-0305 (Linking) VI - 4 IP - 3 DP - 2013 Dec TI - New insights into HLA class I association to Behcet's syndrome in Iranian Azari patients. PG - 101-2 LID - 10.1007/s13317-013-0047-6 [doi] AB - Behcet's syndrome (BS) is a chronic recurrent inflammatory disorder characterized by oral and genital ulcers and ocular inflammation. BS has a complex genetic etiology. To evaluate the influence of human leukocyte antigen (HLA) class I in BS susceptibility in Iranian Azari population, we studied 290 BS patients and 300 healthy controls. As expected, a high frequency of HLA-B5 was found. Remarkably, HLA-B35 frequency was higher in the patient than control group, and the frequency of HLA-B51, HLA-B52, and HLA-BW4 was significantly elevated. Thus, HLA-B5 and HLA-B35 seem to confer susceptibility to BD in Iranian Azari patients. FAU - Shahneh, Fatemeh Zare AU - Shahneh FZ AD - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Hamzavi, Fatemeh AU - Hamzavi F AD - Imam Reza Medical Research and Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Bayazi, Babak AU - Bayazi B AD - Imam Reza Medical Research and Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Bandehagh, Ali AU - Bandehagh A AD - Plant Breeding and Biotechnology Department, Faculty of Agriculture, University of Tabriz, Tabriz, Iran. FAU - Baradaran, Behzad AU - Baradaran B AD - Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Immunology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. LA - eng PT - Journal Article DEP - 20130212 PL - England TA - Auto Immun Highlights JT - Auto- immunity highlights JID - 101532391 PMC - PMC4389025 OTO - NOTNLM OT - Behcet's syndrome OT - HLA antigens OT - HLA typing EDAT- 2013/12/01 00:00 MHDA- 2013/12/01 00:01 PMCR- 2013/02/12 CRDT- 2015/05/23 06:00 PHST- 2012/10/06 00:00 [received] PHST- 2013/01/21 00:00 [accepted] PHST- 2015/05/23 06:00 [entrez] PHST- 2013/12/01 00:00 [pubmed] PHST- 2013/12/01 00:01 [medline] PHST- 2013/02/12 00:00 [pmc-release] AID - 47 [pii] AID - 10.1007/s13317-013-0047-6 [doi] PST - epublish SO - Auto Immun Highlights. 2013 Feb 12;4(3):101-2. doi: 10.1007/s13317-013-0047-6. eCollection 2013 Dec.