PMID- 26001024
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20210102
IS  - 1804-7521 (Electronic)
IS  - 1213-8118 (Linking)
VI  - 159
IP  - 2
DP  - 2015 Jun
TI  - Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1.
PG  - 166-77
LID - 10.5507/bp.2015.025 [doi]
AB  - BACKGROUND: The aim of this review is to provide the information about molecular 
      basis of hypoxia-induced chemoresistance, focusing on the possibility of 
      diagnostic and therapeutic use. RESULTS: Hypoxia is a common feature of tumors 
      and represents an independent prognostic factor in many cancers. It is the result 
      of imbalances in the intake and consumption of oxygen caused by abnormal vessels 
      in the tumor and the rapid proliferation of cancer cells. Hypoxia-induced 
      resistance to cisplatin, doxorubicin, etoposide, melphalan, 5-flouoruracil, 
      gemcitabine, and docetaxel has been reported in a number of experiments. 
      Adaptation of tumor cells to hypoxia has important biological effects. The most 
      studied factor responsible for these effects is hypoxia-inducible factor-1 
      (HIF-1) that significantly contributes to the aggressiveness and chemoresistance 
      of different tumors. The HIF-1 complex, induced by hypoxia, binds to target 
      genes, thereby increasing the expression of many genes. In addition, the 
      expression of hundreds of genes can be also decreased in response to hypoxia in 
      HIF-1 dependent manner, but without the detection of HIF-1 in these genes' 
      promoters. HIF-1 independent mechanisms for drug resistance in hypoxia have been 
      described, however, they are still rarely reported. The first clinical studies 
      focusing on diagnosis of hypoxia and on inhibition of hypoxia-induced changes in 
      cancer cells are starting to yield results. CONCLUSIONS: The adaptation to 
      hypoxia requires many genetic and biochemical responses that regulate one 
      another. Hypoxia-induced resistance is a very complex field and we still know 
      very little about it. Different approaches to circumvent hypoxia in tumors are 
      under development.
FAU - Doktorova, Helena
AU  - Doktorova H
AD  - Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles 
      University in Prague and University Hospital Motol, Prague, Czech Republic.
FAU - Hrabeta, Jan
AU  - Hrabeta J
AD  - Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles 
      University in Prague and University Hospital Motol, Prague, Czech Republic.
FAU - Khalil, Mohamed Ashraf
AU  - Khalil MA
AD  - Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles 
      University in Prague and University Hospital Motol, Prague, Czech Republic.
FAU - Eckschlager, Tomas
AU  - Eckschlager T
AD  - Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles 
      University in Prague and University Hospital Motol, Prague, Czech Republic.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150519
PL  - Czech Republic
TA  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
JT  - Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, 
      Czechoslovakia
JID - 101140142
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/metabolism/physiology
MH  - Apoptosis/genetics/physiology
MH  - Drug Resistance, Neoplasm/genetics/*physiology
MH  - Forecasting
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*physiology
MH  - Mitochondria/metabolism/physiology
MH  - Models, Biological
MH  - Neoplasms/*drug therapy/genetics
MH  - Neoplastic Stem Cells
MH  - Tumor Hypoxia/genetics/*physiology
OTO - NOTNLM
OT  - HIF-1
OT  - chemoresistance
OT  - hypoxia
OT  - hypoxia-induced chemoresistance
EDAT- 2015/05/23 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/05/23 06:00
PHST- 2014/12/22 00:00 [received]
PHST- 2015/05/07 00:00 [accepted]
PHST- 2015/05/23 06:00 [entrez]
PHST- 2015/05/23 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.5507/bp.2015.025 [doi]
PST - ppublish
SO  - Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Jun;159(2):166-77. doi: 
      10.5507/bp.2015.025. Epub 2015 May 19.