PMID- 26001700
OWN - NLM
STAT- MEDLINE
DCOM- 20160810
LR  - 20220311
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Print)
IS  - 0931-041X (Linking)
VI  - 30
IP  - 11
DP  - 2015 Nov
TI  - Impact of gestational age, sex, and postnatal age on urine biomarkers in 
      premature neonates.
PG  - 2037-44
LID - 10.1007/s00467-015-3129-z [doi]
AB  - BACKGROUND: Urine proteins may help in understanding physiology and diagnosing 
      disease in premature infants. Determining how urine proteins vary by degree of 
      prematurity, sex, and postnatal day is warranted. METHODS: We performed a 
      prospective cohort study to assess the independent correlation of 14 urine 
      biomarkers (measured on postnatal days 1-4) with gestational age (GA), sex, and 
      postnatal age in 81 premature infants (mean, 1017 g) without acute kidney injury 
      using a random-effects mixed model. RESULTS: Neutrophil gelatinase-associated 
      lipocalin (NGAL) and vascular endothelial growth factor (VEGF) showed significant 
      associations for sex, GA, and postnatal age. Cystatin C, osteopontin (OPN), and 
      trefoil factor 3 (TFF3) were associated with postnatal age and GA, but not sex. 
      Epithelial growth factor (EGF) and uromodulin were associated with GA only. 
      Clusterin was associated with postnatal age and sex. Albumin was associated with 
      sex only. Beta-2-microglbulin (B2M), osteoactivin, kidney injury molecule -1 
      (KIM-1), and alpha glutathione S-transferase (alphaGST) were associated with 
      postnatal age only. CONCLUSIONS: Postnatal age affects B2M, cystatin C, NGAL, 
      OPN, clusterin, Kim-1, osteoactivin, TFF3, VEGF, alphaGST. GA affects cystatin C, 
      EGF, NGAL, OPN, UMOD, TFF3, and VEGF. Sex affects albumin, NGAL, and clusterin. 
      Interpretation of urine biomarkers will need to account for these associations.
FAU - Saeidi, Behtash
AU  - Saeidi B
AD  - Division of Pediatric Nephrology Department of Pediatrics, University of Alabama 
      at Birmingham, 1600 7th Ave S, Lowder 516, Birmingham, AL, 35233, USA.
FAU - Koralkar, Rajesh
AU  - Koralkar R
AD  - Division of Pediatric Nephrology Department of Pediatrics, University of Alabama 
      at Birmingham, 1600 7th Ave S, Lowder 516, Birmingham, AL, 35233, USA.
FAU - Griffin, Russell L
AU  - Griffin RL
AD  - Department of Epidemiology, University of Alabama at Birmingham, 1665 University 
      Blvd. Ryals Public Health Building Room 220, Birmingham, AL, 35294-0022, USA.
FAU - Halloran, Brian
AU  - Halloran B
AD  - Division of Pediatric Nephrology Department of Pediatrics, University of Alabama 
      at Birmingham, 1600 7th Ave S, Lowder 516, Birmingham, AL, 35233, USA.
FAU - Ambalavanan, Namasivayam
AU  - Ambalavanan N
AD  - Division of Neonatology Department of Pediatrics, University of Alabama at 
      Birmingham, 1700 Sixth Avenue South, Birmingham, AL, 35249, USA.
FAU - Askenazi, David J
AU  - Askenazi DJ
AD  - Division of Pediatric Nephrology Department of Pediatrics, University of Alabama 
      at Birmingham, 1600 7th Ave S, Lowder 516, Birmingham, AL, 35233, USA. 
      daskenazi@peds.uab.edu.
LA  - eng
GR  - UL1TR00165/TR/NCATS NIH HHS/United States
GR  - U10 HD34216/HD/NICHD NIH HHS/United States
GR  - UL1 TR000165/TR/NCATS NIH HHS/United States
GR  - R01 HD066982/HD/NICHD NIH HHS/United States
GR  - R01 HD067126/HD/NICHD NIH HHS/United States
GR  - R01 DE013608/DE/NIDCR NIH HHS/United States
GR  - R01 DK13608-01/DK/NIDDK NIH HHS/United States
GR  - P30 DK079337/DK/NIDDK NIH HHS/United States
GR  - U01 HL122626/HL/NHLBI NIH HHS/United States
GR  - UL1 TR001417/TR/NCATS NIH HHS/United States
GR  - U10 HD034216/HD/NICHD NIH HHS/United States
GR  - P30-DK079337/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150523
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Biomarkers)
SB  - IM
MH  - Age Factors
MH  - Biomarkers/urine
MH  - Cohort Studies
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Premature/*urine
MH  - Infant, Very Low Birth Weight/*urine
MH  - Male
MH  - Prospective Studies
MH  - Sex Characteristics
PMC - PMC4581905
MID - NIHMS693982
OTO - NOTNLM
OT  - Acute kidney injury
OT  - Acute renal failure
OT  - Baseline
OT  - Cystatin C
OT  - Infant
OT  - KIM-1
OT  - NGAL
OT  - Reference
COIS- Potential Conflicts of interest: Dr. Askenazi is speaker for The AKI Foundation.
EDAT- 2015/05/24 06:00
MHDA- 2016/08/11 06:00
PMCR- 2016/11/01
CRDT- 2015/05/24 06:00
PHST- 2015/01/29 00:00 [received]
PHST- 2015/05/04 00:00 [accepted]
PHST- 2015/05/01 00:00 [revised]
PHST- 2015/05/24 06:00 [entrez]
PHST- 2015/05/24 06:00 [pubmed]
PHST- 2016/08/11 06:00 [medline]
PHST- 2016/11/01 00:00 [pmc-release]
AID - 10.1007/s00467-015-3129-z [pii]
AID - 10.1007/s00467-015-3129-z [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2015 Nov;30(11):2037-44. doi: 10.1007/s00467-015-3129-z. Epub 
      2015 May 23.