PMID- 26002466 OWN - NLM STAT- MEDLINE DCOM- 20150824 LR - 20150609 IS - 1090-2104 (Electronic) IS - 0006-291X (Linking) VI - 463 IP - 1-2 DP - 2015 Jul 17-24 TI - Transforming growth factor beta-activated kinase 1 negatively regulates interleukin-1alpha-induced stromal-derived factor-1 expression in vascular smooth muscle cells. PG - 130-6 LID - S0006-291X(15)00963-8 [pii] LID - 10.1016/j.bbrc.2015.05.047 [doi] AB - Stromal-derived Factor-1 (SDF-1) derived from vascular smooth muscle cells (VSMCs) contributes to vascular repair and remodeling in various vascular diseases. In this study, the mechanism underlying regulation of SDF-1 expression by interleukin-1alpha (IL-1alpha) was investigated in primary rat VSMCs. We found IL-1alpha promotes SDF-1 expression by up-regulating CCAAT-enhancer-binding protein beta (C/EBPbeta) in an IkappaB kinase beta (IKKbeta) signaling-dependent manner. Moreover, IL-1alpha-induced expression of C/EBPbeta and SDF-1 was significantly potentiated by knockdown of transforming growth factor beta-activated kinase 1 (TAK1), an upstream activator of IKKbeta signaling. In addition, we also demonstrated that TAK1/p38 mitogen-activated protein kinase (p38 MAPK) signaling exerted negative effect on IL-1alpha-induced expression of C/EBPbeta and SDF-1 through counteracting ROS-dependent up-regulation of nuclear factor erythroid 2-related factor 2 (NRF2). In conclusion, TAK1 acts as an important regulator of IL-1alpha-induced SDF-1 expression in VSMCs, and modulating activity of TAK1 may serve as a potential strategy for modulating vascular repair and remodeling. CI - Copyright (c) 2015 Elsevier Inc. All rights reserved. FAU - Yang, Bin AU - Yang B AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Li, Wei AU - Li W AD - Department of Gerontology, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Zheng, Qichang AU - Zheng Q AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Qin, Tao AU - Qin T AD - Department of Hepatobiliary Pancreatic Surgery, People's Hospital of Zhengzhou University, School of Medicine, Zhengzhou University, Zhengzhou 450003, China. FAU - Wang, Kun AU - Wang K AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Li, Jinjin AU - Li J AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Guo, Bing AU - Guo B AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Yu, Qihong AU - Yu Q AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Wu, Yuzhe AU - Wu Y AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Gao, Yang AU - Gao Y AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Cheng, Xiang AU - Cheng X AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Hu, Shaobo AU - Hu S AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Kumar, Stanley Naveen AU - Kumar SN AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. FAU - Liu, Sanguang AU - Liu S AD - Department of Hepatobiliary Surgery, The Second Hospital, Hebei Medical University, Shijiazhuang 050000, China. Electronic address: sanguang1998@sina.com. FAU - Song, Zifang AU - Song Z AD - Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan 430022, China. Electronic address: zsong@hust.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150520 PL - United States TA - Biochem Biophys Res Commun JT - Biochemical and biophysical research communications JID - 0372516 RN - 0 (CCAAT-Enhancer-Binding Protein-beta) RN - 0 (CXCL12 protein, rat) RN - 0 (Chemokine CXCL12) RN - 0 (Interleukin-1alpha) RN - 0 (NF-E2-Related Factor 2) RN - 0 (Nfe2l2 protein, rat) RN - 0 (RNA, Messenger) RN - 0 (RNA, Small Interfering) RN - 0 (Reactive Oxygen Species) RN - EC 2.7.11.10 (I-kappa B Kinase) RN - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases) RN - EC 2.7.11.25 (MAP Kinase Kinase Kinases) RN - EC 2.7.11.25 (MAP kinase kinase kinase 7) SB - IM MH - Animals MH - CCAAT-Enhancer-Binding Protein-beta/metabolism MH - Cells, Cultured MH - Chemokine CXCL12/genetics/*metabolism MH - Enzyme Activation MH - I-kappa B Kinase/metabolism MH - Interleukin-1alpha/*metabolism MH - MAP Kinase Kinase Kinases/antagonists & inhibitors/genetics/*metabolism MH - MAP Kinase Signaling System MH - Male MH - Muscle, Smooth, Vascular/cytology/metabolism MH - Myocytes, Smooth Muscle/*metabolism MH - NF-E2-Related Factor 2/metabolism MH - RNA, Messenger/genetics/metabolism MH - RNA, Small Interfering/genetics MH - Rats MH - Rats, Sprague-Dawley MH - Reactive Oxygen Species/metabolism MH - Signal Transduction MH - Up-Regulation MH - p38 Mitogen-Activated Protein Kinases/metabolism OTO - NOTNLM OT - CCAAT-enhancer-binding protein beta OT - Interleukin-1 OT - Nuclear factor erythroid 2-related factor 2 OT - Stromal-derived factor-1 OT - Transforming growth factor beta-activated kinase 1 OT - p38 mitogen-activated protein kinase EDAT- 2015/05/24 06:00 MHDA- 2015/08/25 06:00 CRDT- 2015/05/24 06:00 PHST- 2015/04/22 00:00 [received] PHST- 2015/05/03 00:00 [accepted] PHST- 2015/05/24 06:00 [entrez] PHST- 2015/05/24 06:00 [pubmed] PHST- 2015/08/25 06:00 [medline] AID - S0006-291X(15)00963-8 [pii] AID - 10.1016/j.bbrc.2015.05.047 [doi] PST - ppublish SO - Biochem Biophys Res Commun. 2015 Jul 17-24;463(1-2):130-6. doi: 10.1016/j.bbrc.2015.05.047. Epub 2015 May 20.