PMID- 26002587
OWN - NLM
STAT- MEDLINE
DCOM- 20160624
LR  - 20181202
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 38
IP  - 5
DP  - 2015 Oct
TI  - Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by 
      Suppressing TLR4, MyD88 Expression, and NF-kappaB Activation in Microglial Cells.
PG  - 1925-32
LID - 10.1007/s10753-015-0172-7 [doi]
AB  - Microglia are considered as a major target in the prevention of neuroinflammation 
      by modulating the production of pro-inflammatory mediators. Artesunate, a 
      water-soluble artemisinin derivative, exerts an anti-inflammatory effect. In the 
      present study, we showed artesunate dose-dependently suppressed the 
      lipopolysaccharide (LPS)-induced production of nitric oxide (NO), inducible 
      nitric oxide synthase (iNOS), and interleukin-1beta (IL-1beta) in BV2 microglial 
      cells. In addition, artesunate inhibited LPS-induced expression of Toll-like 
      receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), and activation of 
      nuclear factor kappa B (NF-kappaB) by blockade of inhibitor of NF-kappaB (IkappaB) 
      degradation. This data indicate that artesunate attenuates the generation of 
      proinflammatory mediators on LPS-stimulated BV-2 microglial cells. And this 
      effect may be associated with the suppression of TLR4/MyD88/NF-kappaB signaling 
      pathways. Therefore, artesunate may be a potential anti-neuroinflammatory agent.
FAU - Wang, Dunjing
AU  - Wang D
AD  - Department of Neurology, Affiliated Hospital of Xuzhou Medical College, 99 West 
      Huaihai Road, Xuzhou, 221002, Jiangsu Province, China.
FAU - Shi, Jun
AU  - Shi J
FAU - Lv, Shuiqing
AU  - Lv S
FAU - Xu, Weiwei
AU  - Xu W
FAU - Li, Jizhen
AU  - Li J
FAU - Ge, Wei
AU  - Ge W
FAU - Xiao, Chenghua
AU  - Xiao C
FAU - Geng, Deqin
AU  - Geng D
FAU - Liu, Yonghai
AU  - Liu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (Artemisinins)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Myd88 protein, mouse)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (NF-kappa B)
RN  - 0 (Tlr4 protein, mouse)
RN  - 0 (Toll-Like Receptor 4)
RN  - 60W3249T9M (Artesunate)
SB  - IM
MH  - Animals
MH  - Artemisinins/*pharmacology
MH  - Artesunate
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation
MH  - Inflammation Mediators/antagonists & inhibitors/metabolism
MH  - Lipopolysaccharides/*toxicity
MH  - Mice
MH  - Microglia/drug effects/*metabolism
MH  - Myeloid Differentiation Factor 88/antagonists & inhibitors/*metabolism
MH  - NF-kappa B/antagonists & inhibitors/*metabolism
MH  - Toll-Like Receptor 4/antagonists & inhibitors/*metabolism
EDAT- 2015/05/24 06:00
MHDA- 2016/06/25 06:00
CRDT- 2015/05/24 06:00
PHST- 2015/05/24 06:00 [entrez]
PHST- 2015/05/24 06:00 [pubmed]
PHST- 2016/06/25 06:00 [medline]
AID - 10.1007/s10753-015-0172-7 [doi]
PST - ppublish
SO  - Inflammation. 2015 Oct;38(5):1925-32. doi: 10.1007/s10753-015-0172-7.