PMID- 26003194
OWN - NLM
STAT- MEDLINE
DCOM- 20160216
LR  - 20181202
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 84
IP  - 8
DP  - 2015 Aug
TI  - Hypertrophic cardiomyopathy: Cardiac structural and microvascular abnormalities 
      as evaluated with multi-parametric MRI.
PG  - 1480-1486
LID - S0720-048X(15)00228-4 [pii]
LID - 10.1016/j.ejrad.2015.04.028 [doi]
AB  - PURPOSE: To determine the relationship between myocardial structural and 
      microvascular abnormality in hypertrophic cardiomyopathy (HCM) by 
      multi-parametric cardiac MRI. MATERIALS AND METHODS: Twenty-four HCM and eighteen 
      controls were retrospectively included. Left ventricle mass (LVM), LV 
      end-systolic and end-diastolic volume (LVESV, LVEDV), LV ejection fraction 
      (LVEF), and 16-segment wall thickness at ES and ED (SESWT, SEDWT) were assessed 
      with a 2D cine-MRI. Myocardial perfusion (reflected by K(trans)), interstitial 
      volume (Ve) and mean transmit time (MTT) were evaluated with a model-dependent 
      dynamic contrast-enhanced MRI. Myocardial fibrosis was assessed with late 
      gadolinium enhancement (LGE) imaging. RESULTS: K(trans) was significantly 
      decreased in LGE-present (0.74+/-0.15mL/g/min) against LGE-absent 
      (0.55+/-0.14mL/g/min, p=0.030) and normal group (0.81+/-0.32mL/g/min, p<0.001), but 
      was unchanged in LGE-absent against normal group (p>0.05). Ve and MTT were 
      significantly increased in LGE-present (Ve: 26.7+/-15.7%; MTT: 28.6+/-21.3s) against 
      LGE-absent (37.6+/-18.3%; 49.8+/-30.5s) and normal group (19.7+/-6.9%; 15.1+/-3.9s; all 
      p<0.001), and were significantly increased in LGE-absent against normal group 
      (p<0.001). LGE significantly correlated to K(trans), Ve, MTT, and SESWT (rho=0.232, 
      -0.247, -0.443, and -0.207, respectively). K(trans) negatively correlated to 
      SEDWT and SESWT (rho=-0.224 and -0.231). Ve and MTT positively correlated to SEDWT 
      (Ve: rho=0.223; MTT: rho=0.239) and SESWT (Ve: rho=0.248; MTT: rho=0.254). CONCLUSIONS: 
      Consistent relationship was determined between myocardial structural abnormality 
      and microvascular dysfunction in HCM.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhang, Yu-Dong
AU  - Zhang YD
AD  - Department of Radiology, the First Affiliated Hospital with Nanjing Medical 
      University, China. Electronic address: njmu_zyd@163.com.
FAU - Li, Meijiao
AU  - Li M
AD  - Department of Radiology, Peking University First Hospital, China. Electronic 
      address: newgljyk@163.com.
FAU - Qi, Liang
AU  - Qi L
AD  - Department of Radiology, the First Affiliated Hospital with Nanjing Medical 
      University, China. Electronic address: qiliang1120@126.com.
FAU - Wu, Chen-Jiang
AU  - Wu CJ
AD  - Department of Radiology, the First Affiliated Hospital with Nanjing Medical 
      University, China. Electronic address: njmu_wcj@163.com.
FAU - Wang, Xiaoying
AU  - Wang X
AD  - Department of Radiology, Peking University First Hospital, China. Electronic 
      address: cjr.wangxiaoying@vip.163.com.
LA  - eng
PT  - Journal Article
DEP - 20150513
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cardiomyopathy, Hypertrophic/*complications/*pathology
MH  - Contrast Media
MH  - Coronary Vessel Anomalies/*complications
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - Image Enhancement/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Microvessels/*abnormalities
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Cardiac MRI
OT  - Hypertrophic cardiomyopathy
OT  - Microvascular dysfunction
OT  - Myocardial perfusion
OT  - Structural abnormality
EDAT- 2015/05/25 06:00
MHDA- 2016/02/18 06:00
CRDT- 2015/05/25 06:00
PHST- 2015/01/15 00:00 [received]
PHST- 2015/03/28 00:00 [revised]
PHST- 2015/04/27 00:00 [accepted]
PHST- 2015/05/25 06:00 [entrez]
PHST- 2015/05/25 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - S0720-048X(15)00228-4 [pii]
AID - 10.1016/j.ejrad.2015.04.028 [doi]
PST - ppublish
SO  - Eur J Radiol. 2015 Aug;84(8):1480-1486. doi: 10.1016/j.ejrad.2015.04.028. Epub 
      2015 May 13.