PMID- 26003931
OWN - NLM
STAT- MEDLINE
DCOM- 20160421
LR  - 20200109
IS  - 1778-3585 (Electronic)
IS  - 0924-9338 (Linking)
VI  - 30
IP  - 6
DP  - 2015 Sep
TI  - Clinical and functional outcome of assertive outreach for patients with 
      schizophrenic disorder: Results of a quasi-experimental controlled trial.
PG  - 736-42
LID - S0924-9338(15)00089-9 [pii]
LID - 10.1016/j.eurpsy.2015.04.003 [doi]
AB  - BACKGROUND: The majority of studies support modern assertive health service 
      models. However, the evidence is limited for parts of continental Europe, as well 
      as for the pharmacological adherence outcome parameter. METHOD: We conducted a 
      quasi-experimental controlled trial including adult patients with a 
      schizophreniform disorder and a maximum of 60 points on the Global Assessment of 
      Functioning Scale (GAF). Interventions (n=176) and controls (TAU, n=142) were 
      assessed every six-month within one year in 17 study practices in rural areas. 
      Mental and functional state were rated using the Brief Psychiatric Rating Scale 
      (BPRS) and the GAF. Functional limitations and pharmacological adherence were 
      patient-rated using the WHO-Disability Assessment Schedule II (WHODAS-II) and the 
      Medication Adherence Report Scale (MARS). We computed multilevel mixed models. 
      RESULTS: The GAF and BPRS of both groups improved significantly, yet the increase 
      in the intervention group was significantly higher. In contrast, patient-rated 
      variables - WHODAS-II and MARS - neither showed a stable temporal improvement nor 
      a difference between groups. CONCLUSION: Our findings only partly support the 
      investigated AO intervention, because of conflicting results between clinician- 
      and patient-ratings. Accordingly, the benefits of AO need to be further 
      evaluated.
CI  - Copyright (c) 2015 Elsevier Masson SAS. All rights reserved.
FAU - Kastner, D
AU  - Kastner D
AD  - Competence Tandem Integrated Care, Innovation Incubator, Leuphana University 
      Luneburg, Luneburg, Germany; Department of Psychosomatic Medicine and 
      Psychotherapy, University Medical Centre Hamburg-Eppendorf and Schon Clinic 
      Hamburg Eilbek,, Hamburg, Germany. Electronic address: d.kaestner@uke.de.
FAU - Buchtemann, D
AU  - Buchtemann D
AD  - Competence Tandem Integrated Care, Innovation Incubator, Leuphana University 
      Luneburg, Luneburg, Germany.
FAU - Warnke, I
AU  - Warnke I
AD  - Competence Tandem Integrated Care, Innovation Incubator, Leuphana University 
      Luneburg, Luneburg, Germany; Medical Psychology Unit, Hannover Medical School, 
      Hannover, Germany.
FAU - Radisch, J
AU  - Radisch J
AD  - Competence Tandem Integrated Care, Innovation Incubator, Leuphana University 
      Luneburg, Luneburg, Germany; Medical Psychology Unit, Hannover Medical School, 
      Hannover, Germany.
FAU - Baumgardt, J
AU  - Baumgardt J
AD  - Competence Tandem Integrated Care, Innovation Incubator, Leuphana University 
      Luneburg, Luneburg, Germany; Department of Social Work, Faculty of Business and 
      Social Sciences, University of Applied Sciences, Hamburg, Germany.
FAU - Giersberg, S
AU  - Giersberg S
AD  - Competence Tandem Integrated Care, Innovation Incubator, Leuphana University 
      Luneburg, Luneburg, Germany.
FAU - Kopke, K
AU  - Kopke K
AD  - Competence Tandem Integrated Care, Innovation Incubator, Leuphana University 
      Luneburg, Luneburg, Germany.
FAU - Moock, J
AU  - Moock J
AD  - Competence Tandem Integrated Care, Innovation Incubator, Leuphana University 
      Luneburg, Luneburg, Germany.
FAU - Kawohl, W
AU  - Kawohl W
AD  - Competence Tandem Integrated Care, Innovation Incubator, Leuphana University 
      Luneburg, Luneburg, Germany; Department for Psychiatry, Psychotherapy and 
      Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
FAU - Rossler, W
AU  - Rossler W
AD  - Competence Tandem Integrated Care, Innovation Incubator, Leuphana University 
      Luneburg, Luneburg, Germany; Department for Psychiatry, Psychotherapy and 
      Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland; 
      Institute of Psychiatry, Laboratory of Neuroscience (LIM 27), University of Sao 
      Paulo, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150521
PL  - England
TA  - Eur Psychiatry
JT  - European psychiatry : the journal of the Association of European Psychiatrists
JID - 9111820
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Adult
MH  - Brief Psychiatric Rating Scale
MH  - *Disability Evaluation
MH  - Europe
MH  - Female
MH  - Humans
MH  - Male
MH  - Medication Adherence
MH  - Middle Aged
MH  - Models, Organizational
MH  - Outcome Assessment, Health Care
MH  - *Psychotic Disorders/diagnosis/therapy
MH  - Psychotropic Drugs/*therapeutic use
MH  - Rural Health Services/organization & administration
OTO - NOTNLM
OT  - Assertive outreach
OT  - Complex interventions
OT  - Integrated care
OT  - Intensive case management
OT  - Schizophrenia
EDAT- 2015/05/25 06:00
MHDA- 2016/04/22 06:00
CRDT- 2015/05/25 06:00
PHST- 2015/01/25 00:00 [received]
PHST- 2015/04/12 00:00 [revised]
PHST- 2015/04/16 00:00 [accepted]
PHST- 2015/05/25 06:00 [entrez]
PHST- 2015/05/25 06:00 [pubmed]
PHST- 2016/04/22 06:00 [medline]
AID - S0924-9338(15)00089-9 [pii]
AID - 10.1016/j.eurpsy.2015.04.003 [doi]
PST - ppublish
SO  - Eur Psychiatry. 2015 Sep;30(6):736-42. doi: 10.1016/j.eurpsy.2015.04.003. Epub 
      2015 May 21.