PMID- 26004074
OWN - NLM
STAT- MEDLINE
DCOM- 20160113
LR  - 20220317
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Print)
IS  - 0721-832X (Linking)
VI  - 253
IP  - 7
DP  - 2015 Jul
TI  - Photopic full-field electroretinography and optical coherence tomography in type 
      1 diabetic retinopathy.
PG  - 989-97
LID - 10.1007/s00417-015-3034-y [doi]
AB  - PURPOSE: The purpose of this study was to evaluate the role of photopic 
      full-field electroretinography (ERG) and retinal thickness measurements by 
      spectral-domain optical coherence tomography (SD-OCT) in the assessment of 
      disease severity in type 1 diabetic retinopathy. METHODS: A population-based 
      cohort of 151 patients with type 1 diabetes underwent a complete ophthalmic 
      examination, including photopic full-field ERG and SD-OCT for retinal thickness 
      measurements. Stereoscopic fundus photographs were taken according to the Early 
      Treatment Diabetic Retinopathy Study protocol, and the classification of diabetic 
      retinopathy was based on the International Clinical Diabetic Retinopathy Disease 
      Severity Scale. Associations between photographically determined retinopathy 
      level, b-wave amplitude and peak time of the photopic single-flash and 30-Hz 
      flicker ERG, and central retinal thickness parameters were evaluated. RESULTS: 
      For all ERG measurements, the amplitude decreased and peak time increased with 
      progression of the disease, but these associations lost statistical significance 
      after adjusting for age and excluding laser-treated patients. Mean retinal 
      thickness was significantly associated with the b-wave amplitude of photopic 
      single-flash and 30-Hz flicker responses (r(2) = 0.08, p = 0.006; and 
      r(2) = 0.05, p = 0.025, respectively), but revealed no association with 
      retinopathy level. CONCLUSIONS: Photopic full-field ERG and SD-OCT-derived 
      retinal thickness parameters have limited clinical value in the staging of 
      diabetic retinopathy. However, thinning of the central retina leads to 
      significant functional impairment and may reflect an ongoing neurodegenerative 
      process in the retinal tissue.
FAU - Jansson, Ragnhild Wivestad
AU  - Jansson RW
AD  - Department of Clinical Medicine, Section of Ophthalmology, University of Bergen, 
      Bergen, Norway, ragnhild.wivestad.jansson@helse-bergen.no.
FAU - Raeder, Maria Baroy
AU  - Raeder MB
FAU - Krohn, Jorgen
AU  - Krohn J
LA  - eng
PT  - Journal Article
DEP - 20150526
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
CIN - Graefes Arch Clin Exp Ophthalmol. 2015 Jul;253(7):987-8. PMID: 25956999
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Color Vision
MH  - Diabetes Mellitus, Type 1/*complications
MH  - Diabetic Retinopathy/*classification/*diagnosis
MH  - *Electroretinography
MH  - Female
MH  - Humans
MH  - Light
MH  - Macular Edema/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Photic Stimulation
MH  - Retina/*pathology
MH  - *Tomography, Optical Coherence
MH  - Young Adult
PMC - PMC4483250
EDAT- 2015/05/26 06:00
MHDA- 2016/01/14 06:00
PMCR- 2015/05/26
CRDT- 2015/05/26 06:00
PHST- 2014/11/20 00:00 [received]
PHST- 2015/04/22 00:00 [accepted]
PHST- 2015/04/06 00:00 [revised]
PHST- 2015/05/26 06:00 [entrez]
PHST- 2015/05/26 06:00 [pubmed]
PHST- 2016/01/14 06:00 [medline]
PHST- 2015/05/26 00:00 [pmc-release]
AID - 3034 [pii]
AID - 10.1007/s00417-015-3034-y [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2015 Jul;253(7):989-97. doi: 
      10.1007/s00417-015-3034-y. Epub 2015 May 26.