PMID- 26004225
OWN - NLM
STAT- MEDLINE
DCOM- 20160614
LR  - 20171116
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 114
DP  - 2015 Oct 10
TI  - Comparative pharmacokinetic profiles of tectorigenin in rat plasma by UPLC-MS/MS 
      after oral administration of Iris tectorum Maxim extract and pure tectoridin.
PG  - 34-41
LID - S0731-7085(15)00291-5 [pii]
LID - 10.1016/j.jpba.2015.05.005 [doi]
AB  - Iris tectorum Maxim, a well-known herb medicine, is commonly used for treatment 
      of inflammation, cough, and pharyngitis for a long time in China. Tectoridin, 
      main active ingredient of Iris tectorum Maxim, is often used for its quality 
      control. This study was aimed to analyze the pharmacokinetic profile of 
      tectorigenin (the metabolite of tectoridin) after oral administration of I. 
      tectorum Maxim extract, and to compare the pharmacokinetic characterization of 
      tectorigenin after oral administration of I. tectorum Maxim extract (ITME) and 
      pure tectoridin (PT) in rats. In addition, a simple, reliable and sensitive 
      UPLC-MS/MS method was developed for determination of tectorigenin in rat plasma, 
      using kaempferol as internal standard. The processed samples were separated on a 
      Poroshell 120 SB-C(1)(8) column and detected by positive electrospray ionization in 
      multiple reaction monitoring (MRM) mode. The method validation results indicated 
      that the established method was simple, specific and reliable. The 
      pharmacokinetic results showed that the plasma concentration of tectorigenin in 
      ITME group was much higher than that of the PT group (p<0.01). Moreover, compared 
      to PT group, t(1)/(2) value and AUC(0-infinity) value were also notably increased in ITME 
      group (p<0.01). In conclusion, potential interaction exists between those 
      chemical components in ITME, and the co-existing components in ITME could notably 
      promote the absorption of tectoridin in rats, however, the exact compound(s) 
      which enhance the absorption of tectoridin should be investigated in future 
      study.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Yang, Min
AU  - Yang M
AD  - State Key Laboratory of Natural Medicines, China Pharmaceutical University, 
      Nanjing 210009, PR China.
FAU - Yang, Xiaolin
AU  - Yang X
AD  - Jiangsu Provincial Center for Research and Development of Marine Drugs, Nanjing 
      University of Traditional Chinese Medicine, Nanjing 210029, PR China.
FAU - An, Jinmeng
AU  - An J
AD  - State Key Laboratory of Natural Medicines, China Pharmaceutical University, 
      Nanjing 210009, PR China.
FAU - Xiao, Wei
AU  - Xiao W
AD  - Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222001, PR China.
FAU - Wang, Zhenzhong
AU  - Wang Z
AD  - Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222001, PR China.
FAU - Huang, Wenzhe
AU  - Huang W
AD  - Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222001, PR China.
FAU - Yang, Zhonglin
AU  - Yang Z
AD  - State Key Laboratory of Natural Medicines, China Pharmaceutical University, 
      Nanjing 210009, PR China. Electronic address: yzl1950@126.com.
FAU - Li, Fei
AU  - Li F
AD  - State Key Laboratory of Natural Medicines, China Pharmaceutical University, 
      Nanjing 210009, PR China. Electronic address: Lifeicpu@163.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150511
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Isoflavones)
RN  - 0 (Kaempferols)
RN  - 0 (Plant Extracts)
RN  - 731P2LE49E (kaempferol)
RN  - 855130H9CO (tectorigenin)
RN  - 968X515NZH (tectoridin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Area Under Curve
MH  - Calibration
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Drugs, Chinese Herbal/administration & dosage/analysis
MH  - Hydrolysis
MH  - Iris/*chemistry
MH  - Isoflavones/*blood/chemistry
MH  - Kaempferols/analysis
MH  - Limit of Detection
MH  - Male
MH  - Plant Extracts/administration & dosage/*chemistry
MH  - Quality Control
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproducibility of Results
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - Iris tectorum Maxim
OT  - Pharmacokinetics
OT  - Tectoridin
OT  - Tectorigenin
OT  - UPLC-MS/MS
EDAT- 2015/05/26 06:00
MHDA- 2016/06/15 06:00
CRDT- 2015/05/26 06:00
PHST- 2015/03/06 00:00 [received]
PHST- 2015/05/03 00:00 [revised]
PHST- 2015/05/06 00:00 [accepted]
PHST- 2015/05/26 06:00 [entrez]
PHST- 2015/05/26 06:00 [pubmed]
PHST- 2016/06/15 06:00 [medline]
AID - S0731-7085(15)00291-5 [pii]
AID - 10.1016/j.jpba.2015.05.005 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2015 Oct 10;114:34-41. doi: 10.1016/j.jpba.2015.05.005. Epub 
      2015 May 11.