PMID- 26005438
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150525
LR  - 20220311
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 6
DP  - 2015
TI  - Dendritic cells as Achilles' heel and Trojan horse during varicella zoster virus 
      infection.
PG  - 417
LID - 10.3389/fmicb.2015.00417 [doi]
LID - 417
AB  - Varicella zoster virus (VZV), a human alphaherpesvirus, causes varicella and 
      subsequently establishes latency within sensory nerve ganglia. Later in life VZV 
      can reactivate to cause herpes zoster. A reduced frequency of VZV-specific T 
      cells is strongly associated with herpes zoster illustrating that these immune 
      cells are central to control latency. Dendritic cells (DCs) are required for the 
      generation of VZV-specific T cells. However, DCs can also be infected in vitro 
      and in vivo allowing VZV to evade the antiviral immune response. Thus, DCs 
      represent the immune systems' Achilles heel. Uniquely among the human 
      herpesviruses, VZV infects both DCs and T cells, and exploits both as Trojan 
      horses. During primary infection VZV-infected DCs traffic to the draining lymph 
      nodes and tonsils, where the virus is transferred to T cells. VZV-infected T 
      cells subsequently spread infection throughout the body to give the typical 
      varicella skin rash. The delicate interplay between VZV and DCs and its 
      consequences for viral immune evasion and viral dissemination will be discussed 
      in this article.
FAU - Schonrich, Gunther
AU  - Schonrich G
AD  - Institute of Medical Virology, Helmut-Ruska-Haus, Charite-Universitatsmedizin 
      Berlin , Berlin, Germany.
FAU - Raftery, Martin J
AU  - Raftery MJ
AD  - Institute of Medical Virology, Helmut-Ruska-Haus, Charite-Universitatsmedizin 
      Berlin , Berlin, Germany.
LA  - eng
PT  - Journal Article
DEP - 20150508
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC4424880
OTO - NOTNLM
OT  - dendritic cells
OT  - herpesviruses
OT  - varicella zoster virus
OT  - viral immune evasion
OT  - viral pathogenesis
EDAT- 2015/05/26 06:00
MHDA- 2015/05/26 06:01
PMCR- 2015/05/08
CRDT- 2015/05/26 06:00
PHST- 2015/02/23 00:00 [received]
PHST- 2015/04/20 00:00 [accepted]
PHST- 2015/05/26 06:00 [entrez]
PHST- 2015/05/26 06:00 [pubmed]
PHST- 2015/05/26 06:01 [medline]
PHST- 2015/05/08 00:00 [pmc-release]
AID - 10.3389/fmicb.2015.00417 [doi]
PST - epublish
SO  - Front Microbiol. 2015 May 8;6:417. doi: 10.3389/fmicb.2015.00417. eCollection 
      2015.