PMID- 2600664
OWN - NLM
STAT- MEDLINE
DCOM- 19900201
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 119
IP  - 11
DP  - 1989 Nov
TI  - Hepatic cysteine sulfinic acid decarboxylase activity in rats fed various levels 
      of dietary casein.
PG  - 1593-7
AB  - A series of experiments was conducted to examine the effects of dietary protein 
      intake on hepatic cysteine sulfinic acid decarboxylase (EC 4.1.1.29) activity and 
      urinary taurine excretion. When rats were fed diets containing 18, 30, 45 or 60% 
      casein for 1 wk, hepatic cysteine sulfinic acid decarboxylase activity (CSAD) 
      decreased in a progressive and significant manner. Enzyme activity in rats fed a 
      60% casein diet was 25% of the activity measured in rats fed 18% casein. The time 
      course of the change in CSAD activity was examined in rats fed a 60% casein diet. 
      Within 24 h of switching rats from a moderate (18% casein) to high (60% casein) 
      protein diet, enzyme activity decreased by 50% and continued to decline in rats 
      fed the high protein diet for 7 d. The observed decrease in enzyme activity was 
      reversed when rats were refed the 18% casein diet. The half-life of CSAD was 
      calculated to be 2 and 7 d during the diet switch from 18 to 60% casein and from 
      60 to 18% casein, respectively. The change in enzyme activity was evident after a 
      single high protein meal. In contrast to CSAD activity, urinary taurine excretion 
      increased 140-fold within 2 d of switching rats from an 18 to 60% casein diet. 
      Upon refeeding of the 18% casein diet taurine excretion rapidly decreased. These 
      findings indicate that CSAD responds in a rapid and reversible manner to dietary 
      protein.
FAU - Jerkins, A A
AU  - Jerkins AA
AD  - Department of Nutritional Sciences, University of Wisconsin, Madison 53706.
FAU - Bobroff, L E
AU  - Bobroff LE
FAU - Steele, R D
AU  - Steele RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Caseins)
RN  - 1EQV5MLY3D (Taurine)
RN  - EC 4.1.1.- (Carboxy-Lyases)
RN  - EC 4.1.1.29 (sulfoalanine decarboxylase)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Carboxy-Lyases/*metabolism
MH  - Caseins/*administration & dosage/pharmacology
MH  - Liver/*enzymology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Taurine/urine
MH  - Time Factors
EDAT- 1989/11/01 00:00
MHDA- 1989/11/01 00:01
CRDT- 1989/11/01 00:00
PHST- 1989/11/01 00:00 [pubmed]
PHST- 1989/11/01 00:01 [medline]
PHST- 1989/11/01 00:00 [entrez]
AID - 10.1093/jn/119.11.1593 [doi]
PST - ppublish
SO  - J Nutr. 1989 Nov;119(11):1593-7. doi: 10.1093/jn/119.11.1593.