PMID- 26007157
OWN - NLM
STAT- MEDLINE
DCOM- 20160414
LR  - 20221207
IS  - 1432-1750 (Electronic)
IS  - 0341-2040 (Linking)
VI  - 193
IP  - 4
DP  - 2015 Aug
TI  - The Relationship of HLA-DQ Alleles with Tuberculosis Risk: A Meta-analysis.
PG  - 521-30
LID - 10.1007/s00408-015-9747-1 [doi]
AB  - BACKGROUND: The human leukocyte antigen (HLA) system plays an important role in 
      regulating immune response because it takes part in the defense against 
      pathogens. Some individual research studies have demonstrated that HLA class II 
      genes play an important role in tuberculosis (TB) in several populations. 
      However, the results were controversial. A meta-analysis was performed to examine 
      the associations between HLA alleles and TB risk. METHODS: Relevant studies on 
      the association of HLA-DQA1 and DQB1 alleles with TB were included in the 
      analyses. We examined papers published in the PubMed and EMBASE databases up to 
      June 10, 2014. The odds ratios (ORs) and 95 % confidence intervals (CI) were 
      analyzed from fixed-effects or random-effects models. Subgroup analyses were 
      conducted by ethnicity. RESULTS: This meta-analysis included 12 studies with DQB1 
      (1290 TB patients and 1471 controls) and 6 studies with DQA1 (453 TB patients and 
      648 controls). Only DQB1*0601 was found to have a significant association with an 
      increased risk for TB [OR (95 % CI) = 1.68 (1.32-2.14), P = 0.000]. No 
      significant association with TB risk was found in any HLA-DQA1 allele or in other 
      HLA-DQB1 alleles. DQB1*0601 was significantly related to an increased risk of TB 
      in Asian group, whereas no evidence was found in the non-Asian group. CONCLUSION: 
      Our meta-analysis supports the hypothesis that the specific HLA-DQB1 may be 
      regarded as a marker of real worth for predicting the risk of developing TB. The 
      same result was shown in Asian population.
FAU - Li, Cuiping
AU  - Li C
AD  - School of Public Health, Guangxi Medical University, Nanning, People's Republic 
      of China.
FAU - Zhou, Ying
AU  - Zhou Y
FAU - Xiang, Xue
AU  - Xiang X
FAU - Zhou, Yang
AU  - Zhou Y
FAU - He, Min
AU  - He M
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150526
PL  - United States
TA  - Lung
JT  - Lung
JID - 7701875
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - *Alleles
MH  - Asian People/genetics
MH  - HLA-DQ alpha-Chains/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - Humans
MH  - Risk Factors
MH  - Tuberculosis, Pulmonary/*genetics
EDAT- 2015/05/27 06:00
MHDA- 2016/04/15 06:00
CRDT- 2015/05/27 06:00
PHST- 2014/12/16 00:00 [received]
PHST- 2015/05/13 00:00 [accepted]
PHST- 2015/05/27 06:00 [entrez]
PHST- 2015/05/27 06:00 [pubmed]
PHST- 2016/04/15 06:00 [medline]
AID - 10.1007/s00408-015-9747-1 [doi]
PST - ppublish
SO  - Lung. 2015 Aug;193(4):521-30. doi: 10.1007/s00408-015-9747-1. Epub 2015 May 26.