PMID- 26009193
OWN - NLM
STAT- MEDLINE
DCOM- 20160222
LR  - 20150526
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Linking)
VI  - 43
IP  - 3
DP  - 2015 Jun
TI  - Connexin 43 ubiquitination determines the fate of gap junctions: restrict to 
      survive.
PG  - 471-5
LID - 10.1042/BST20150036 [doi]
AB  - Connexins (Cxs) are transmembrane proteins that form channels which allow direct 
      intercellular communication (IC) between neighbouring cells via gap junctions. 
      Mechanisms that modulate the amount of channels at the plasma membrane have 
      emerged as important regulators of IC and their de-regulation has been associated 
      with various diseases. Although Cx-mediated IC can be modulated by different 
      mechanisms, ubiquitination has been described as one of the major 
      post-translational modifications involved in Cx regulation and consequently IC. 
      In this review, we focus on the role of ubiquitin and its effect on gap junction 
      intercellular communication.
FAU - Ribeiro-Rodrigues, Teresa M
AU  - Ribeiro-Rodrigues TM
AD  - *Centre of Ophthalmology and Vision Sciences, Institute of Biomedical Imaging and 
      Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga de 
      Sta Comba, 3000-354 Coimbra, Portugal.
FAU - Catarino, Steve
AU  - Catarino S
AD  - *Centre of Ophthalmology and Vision Sciences, Institute of Biomedical Imaging and 
      Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga de 
      Sta Comba, 3000-354 Coimbra, Portugal.
FAU - Pinho, Maria J
AU  - Pinho MJ
AD  - *Centre of Ophthalmology and Vision Sciences, Institute of Biomedical Imaging and 
      Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga de 
      Sta Comba, 3000-354 Coimbra, Portugal.
FAU - Pereira, Paulo
AU  - Pereira P
AD  - *Centre of Ophthalmology and Vision Sciences, Institute of Biomedical Imaging and 
      Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga de 
      Sta Comba, 3000-354 Coimbra, Portugal.
FAU - Girao, Henrique
AU  - Girao H
AD  - *Centre of Ophthalmology and Vision Sciences, Institute of Biomedical Imaging and 
      Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Azinhaga de 
      Sta Comba, 3000-354 Coimbra, Portugal.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Connexin 43)
RN  - 0 (GJA1 protein, human)
RN  - 0 (Ubiquitin)
SB  - IM
MH  - Autophagy/*genetics
MH  - Connexin 43/*genetics/metabolism
MH  - Endosomes/metabolism
MH  - Gap Junctions/*genetics/metabolism
MH  - Humans
MH  - Proteolysis
MH  - Ubiquitin/*genetics/metabolism
MH  - Ubiquitination/genetics
EDAT- 2015/05/27 06:00
MHDA- 2016/02/24 06:00
CRDT- 2015/05/27 06:00
PHST- 2015/05/27 06:00 [entrez]
PHST- 2015/05/27 06:00 [pubmed]
PHST- 2016/02/24 06:00 [medline]
AID - BST20150036 [pii]
AID - 10.1042/BST20150036 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2015 Jun;43(3):471-5. doi: 10.1042/BST20150036.