PMID- 26011616
OWN - NLM
STAT- MEDLINE
DCOM- 20151203
LR  - 20161125
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 529
DP  - 2015 Oct 1
TI  - Food intake and serum persistent organic pollutants in the Greenlandic pregnant 
      women: The ACCEPT sub-study.
PG  - 198-212
LID - S0048-9697(15)30081-4 [pii]
LID - 10.1016/j.scitotenv.2015.05.022 [doi]
AB  - The Greenlandic Inuit have high blood concentrations of environmental persistent 
      organic pollutants (POPs). High POP concentrations have been associated with age, 
      smoking and consumption of marine mammals. Studies have indicated that exposure 
      to POPs during pregnancy may adversely affect fetal and child development. To 
      assess geographical differences in diet, lifestyle and environmental contaminant 
      exposure among pregnant women in Greenland, blood samples and questionnaire data 
      were collected from 207 pregnant women in five Greenlandic regions (North, Disco 
      Bay, West, South and East). Blood samples were analyzed for 11 organochlorine 
      pesticides (OCPs), 14 polychlorinated biphenyls (PCBs), 5 polybrominated diphenyl 
      ethers (PBDEs), 15 perfluoroalkylated substances (PFASs) and 63 metals. A trend 
      of higher intake of marine mammals in the East and North regions was reflected by 
      a higher n-3/n-6 fatty acid ratio. Participants in the East region tended also to 
      have higher intake of terrestrial species. A significant higher seabird intake 
      was seen for pregnant women in the West region. Significant regional differences 
      were found for blood concentrations of PCBs, OCPs, PFASs and mercury, with higher 
      levels in the North and East regions. PFASs were significantly associated with 
      PCBs and OCPs in most of the regions. In the North region, PFASs were associated 
      with both selenium and mercury. No significant regional difference was observed 
      for PBDEs. The regional differences of blood levels of POPs and mercury were 
      related to differences in intake of the traditional food. Compared to earlier 
      reports, decreased levels of legacy POPs, Hg and Pb and perfluorooctane sulfonate 
      and perfluorooctanoic acid were observed, but the levels of PFAS congeners 
      perfluorohexane sulfonate and perfluorononanoic acid were sustained. The 
      detection of POPs and heavy metals in maternal blood indicates fetal exposure to 
      these compounds possibly influencing fetal development.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Long, Manhai
AU  - Long M
AD  - Centre for Arctic Health & Unit of Cellular and Molecular Toxicology, Department 
      of Public Health, Aarhus University, Aarhus, Denmark. Electronic address: 
      ml@ph.au.dk.
FAU - Knudsen, Ane-Kersti Skaarup
AU  - Knudsen AK
AD  - Centre for Arctic Health & Unit of Cellular and Molecular Toxicology, Department 
      of Public Health, Aarhus University, Aarhus, Denmark. Electronic address: 
      aksk@ph.au.dk.
FAU - Pedersen, Henning Sloth
AU  - Pedersen HS
AD  - Primary Health Care Center, Nuuk, Greenland. Electronic address: HSP@peqqik.gl.
FAU - Bonefeld-Jorgensen, Eva Cecilie
AU  - Bonefeld-Jorgensen EC
AD  - Centre for Arctic Health & Unit of Cellular and Molecular Toxicology, Department 
      of Public Health, Aarhus University, Aarhus, Denmark. Electronic address: 
      ebj@ph.au.dk.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150523
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Metals, Heavy)
RN  - 0 (Pesticides)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - FX3WJ41CMX (perflexane)
SB  - IM
MH  - Adult
MH  - Alkanesulfonic Acids/blood
MH  - Caprylates/blood
MH  - Diet/statistics & numerical data
MH  - Eating
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Fluorocarbons/blood
MH  - Greenland
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Maternal Exposure/*statistics & numerical data
MH  - Metals, Heavy/blood
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Pregnancy
OTO - NOTNLM
OT  - Contaminants
OT  - Diet
OT  - Greenland
OT  - Lifestyle
OT  - Pregnant
EDAT- 2015/05/27 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/05/27 06:00
PHST- 2014/12/22 00:00 [received]
PHST- 2015/05/06 00:00 [revised]
PHST- 2015/05/06 00:00 [accepted]
PHST- 2015/05/27 06:00 [entrez]
PHST- 2015/05/27 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0048-9697(15)30081-4 [pii]
AID - 10.1016/j.scitotenv.2015.05.022 [doi]
PST - ppublish
SO  - Sci Total Environ. 2015 Oct 1;529:198-212. doi: 10.1016/j.scitotenv.2015.05.022. 
      Epub 2015 May 23.