PMID- 26014802
OWN - NLM
STAT- MEDLINE
DCOM- 20160217
LR  - 20220316
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 212
IP  - 11
DP  - 2015 Dec 1
TI  - A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen 
      in a Subgroup of Patients With Lyme Disease.
PG  - 1841-50
LID - 10.1093/infdis/jiv310 [doi]
AB  - To discover novel autoantigens associated with Lyme arthritis (LA), we identified 
      T-cell epitopes presented in vivo by human leukocyte antigen (HLA)-DR molecules 
      in patients' inflamed synovial tissue or joint fluid and tested each epitope for 
      autoreactivity. Using this approach, we identified the highly expressed human 
      protein, apolipoprotein B-100 (apoB-100), as a target of T- and B-cell responses 
      in a subgroup of LA patients. Additionally, the joint fluid of these patients had 
      markedly elevated levels of apoB-100 protein, which may contribute to its 
      autoantigenicity. In patients with antibiotic-refractory LA, the magnitude of 
      apoB-100 antibody responses correlated with increased numbers of plasma cells in 
      synovial tissue, greater numbers and activation of endothelial cells, and more 
      synovial fibroblast proliferation. Thus, a subset of LA patients have high levels 
      of apoB-100 in their joints and autoreactive T- and B-cell responses to the 
      protein, which likely contributes to pathogenic autoimmunity in patients with 
      antibiotic-refractory LA.
CI  - (c) The Author 2015. Published by Oxford University Press on behalf of the 
      Infectious Diseases Society of America. All rights reserved. For Permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Crowley, Jameson T
AU  - Crowley JT
AD  - Center for Immunology and Inflammatory Diseases, Division of Rheumatology, 
      Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School.
FAU - Drouin, Elise E
AU  - Drouin EE
AD  - Center for Immunology and Inflammatory Diseases, Division of Rheumatology, 
      Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School.
FAU - Pianta, Annalisa
AU  - Pianta A
AD  - Center for Immunology and Inflammatory Diseases, Division of Rheumatology, 
      Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School.
FAU - Strle, Klemen
AU  - Strle K
AD  - Center for Immunology and Inflammatory Diseases, Division of Rheumatology, 
      Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School.
FAU - Wang, Qi
AU  - Wang Q
AD  - Center for Biomedical Mass Spectrometry, Boston University School of Medicine, 
      Massachusetts.
FAU - Costello, Catherine E
AU  - Costello CE
AD  - Center for Biomedical Mass Spectrometry, Boston University School of Medicine, 
      Massachusetts.
FAU - Steere, Allen C
AU  - Steere AC
AD  - Center for Immunology and Inflammatory Diseases, Division of Rheumatology, 
      Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School.
LA  - eng
GR  - K01 AR062098/AR/NIAMS NIH HHS/United States
GR  - HHSN268201000031C/HL/NHLBI NIH HHS/United States
GR  - R01 AI-110175/AI/NIAID NIH HHS/United States
GR  - S10 OD010724/OD/NIH HHS/United States
GR  - K01-AR062098/AR/NIAMS NIH HHS/United States
GR  - HHSN268201000031C/PHS HHS/United States
GR  - R01 AI101175/AI/NIAID NIH HHS/United States
GR  - P41 GM104603/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150526
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Apolipoprotein B-100)
RN  - 0 (Autoantigens)
SB  - IM
MH  - Apolipoprotein B-100/*immunology
MH  - Autoantigens/*immunology
MH  - B-Lymphocytes/immunology
MH  - Borrelia burgdorferi
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Lyme Disease/epidemiology/*immunology
MH  - Middle Aged
MH  - T-Lymphocytes/immunology
PMC - PMC4633766
OTO - NOTNLM
OT  - Borrelia burgdorferi
OT  - Lyme arthritis
OT  - Lyme disease
OT  - apolipoprotein B
OT  - autoantibodies
OT  - autoimmunity
OT  - erythema migrans
EDAT- 2015/05/28 06:00
MHDA- 2016/02/18 06:00
PMCR- 2016/12/01
CRDT- 2015/05/28 06:00
PHST- 2015/03/17 00:00 [received]
PHST- 2015/05/19 00:00 [accepted]
PHST- 2015/05/28 06:00 [entrez]
PHST- 2015/05/28 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - jiv310 [pii]
AID - 10.1093/infdis/jiv310 [doi]
PST - ppublish
SO  - J Infect Dis. 2015 Dec 1;212(11):1841-50. doi: 10.1093/infdis/jiv310. Epub 2015 
      May 26.