PMID- 26014903 OWN - NLM STAT- MEDLINE DCOM- 20180629 LR - 20221207 IS - 1756-185X (Electronic) IS - 1756-1841 (Linking) VI - 20 IP - 8 DP - 2017 Aug TI - HLA-DPB1 variant rs3117242 is associated with anti-neutrophil cytoplasmic antibody-associated vasculitides in a Han Chinese population. PG - 1009-1015 LID - 10.1111/1756-185X.12561 [doi] AB - AIM: The vasculitis diseases granulomatosis with polyangiitis (GPA) and microscopic polyangitis (MPA) are the two major forms of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). A recent genome-wide association study has shown that the genes HLA-DPB1 and HLA-DQ conferred susceptibility to GPA and MPA, respectively. We investigated the linkage between putative AAV-related genes (HLA-DPB1, ARHGAP18, CD226, CTLA-4, MOSPD2 and PRTN3) and AAV in a Han Chinese population. METHOD: A Sequenom MassAarray system (iPLEX assay, Sequenom, San Diego, CA, USA) was used to genotype single nucleotide polymorphisms (SNPs) in 176 Han Chinese patients with AAV (100 with GPA, 76 with MPA) and 485 ethnically matched healthy controls. RESULT: The frequency of the rs3117242 variant T allele (HLA-DPB1) was significantly higher in GPA patients than in the controls (68.0% compared with 50.4%, OR = 2.09, 95% CI: 1.51-2.88, Bonferroni corrected P-value [Pc] = 6.24E-5), but was not significantly different between MPA patients and controls (Pc = 0.14). The same results were obtained via genotype distribution and logistic regression analysis based on three genetic models. The allele and genotype distributions of the other polymorphisms were not significantly associated with AAV patients as a whole or GPA or MPA patients considered separately. CONCLUSION: The rs3117242 of HLA-DPB1 could be considered a genetic risk factor for GPA in Chinese Han people. These findings provide further insights and clues into the etiology of GPA and MPA. CI - (c) 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd. FAU - Wu, Ziyan AU - Wu Z AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Wu, Qingjun AU - Wu Q AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Xu, Juanjuan AU - Xu J AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Chen, Si AU - Chen S AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Sun, Fei AU - Sun F AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Li, Ping AU - Li P AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Bai, Yina AU - Bai Y AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Zheng, Wenjie AU - Zheng W AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Chen, Hua AU - Chen H AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Zhang, Fengchun AU - Zhang F AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. FAU - Li, Yongzhe AU - Li Y AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. LA - eng PT - Journal Article DEP - 20150527 PL - England TA - Int J Rheum Dis JT - International journal of rheumatic diseases JID - 101474930 RN - 0 (HLA-DP beta-Chains) RN - 0 (HLA-DPB1 antigen) SB - IM MH - Adult MH - Aged MH - Asian People/genetics MH - Case-Control Studies MH - Chi-Square Distribution MH - China/epidemiology MH - Female MH - Gene Frequency MH - Genetic Association Studies MH - Genetic Predisposition to Disease MH - Granulomatosis with Polyangiitis/diagnosis/ethnology/*genetics/immunology MH - HLA-DP beta-Chains/*genetics/immunology MH - Humans MH - Male MH - Microscopic Polyangiitis/ethnology/genetics/immunology MH - Middle Aged MH - Odds Ratio MH - Phenotype MH - *Polymorphism, Single Nucleotide MH - Risk Factors OTO - NOTNLM OT - AAV OT - GPA OT - Chinese OT - HLA-DPB1 OT - Han OT - rs3117242 EDAT- 2015/05/28 06:00 MHDA- 2018/06/30 06:00 CRDT- 2015/05/28 06:00 PHST- 2015/05/28 06:00 [pubmed] PHST- 2018/06/30 06:00 [medline] PHST- 2015/05/28 06:00 [entrez] AID - 10.1111/1756-185X.12561 [doi] PST - ppublish SO - Int J Rheum Dis. 2017 Aug;20(8):1009-1015. doi: 10.1111/1756-185X.12561. Epub 2015 May 27.