PMID- 26016167
OWN - NLM
STAT- MEDLINE
DCOM- 20150702
LR  - 20211203
IS  - 0094-6354 (Print)
IS  - 0094-6354 (Linking)
VI  - 83
IP  - 2
DP  - 2015 Apr
TI  - Evaluation of the anxiolytic and antidepressant effects of asiatic acid, a 
      compound from Gotu kola or Centella asiatica, in the male Sprague Dawley rat.
PG  - 91-8
AB  - Herbal medication use continues to rise and interactions with existing 
      medications propose risks and may have significant effects and consequences on 
      the administration of anesthesia. The purpose of this study was to investigate 
      the anxiolytic and antidepressant effects of asiatic acid and its potential 
      modulation of the gamma-aminobutyric acid (GABAA) receptor. Fifty-five male Sprague 
      Dawley rats were divided into 5 groups: vehicle (DMSO), asiatic acid (AA), 
      midazolam, or a combination of flumazenil + AA or midazolam + AA, and injected 
      intraperitoneally 30 minutes prior to testing. The rats were tested on the 
      Elevated Plus Maze (EPM) and the Forced Swim Test (FST). Data were analyzed using 
      a two-tailed multivariate analysis of variance (MANOVA). Significance was found 
      regarding the ratio of open arm time, maximum speed, and time spent mobile in the 
      AA group and the midazolam + AA group (P < .05). Flumazenil decreased the 
      anxiolytic effects, suggesting that AA modulates the benzodiazepine site on the 
      GABAA receptor. Further studies are recommended to determine the efficacy of 
      prolonged treatment for anxiety and depression.
FAU - Ceremuga, Tomas Eduardo
AU  - Ceremuga TE
FAU - Valdivieso, Debra
AU  - Valdivieso D
FAU - Kenner, Catherine
AU  - Kenner C
FAU - Lucia, Amy
AU  - Lucia A
FAU - Lathrop, Keith
AU  - Lathrop K
FAU - Stailey, Owen
AU  - Stailey O
FAU - Bailey, Heather
AU  - Bailey H
FAU - Criss, Jonathan
AU  - Criss J
FAU - Linton, Jessica
AU  - Linton J
FAU - Fried, Jordan
AU  - Fried J
FAU - Taylor, Andrew
AU  - Taylor A
FAU - Padron, Gina
AU  - Padron G
FAU - Johnson, Arthur Don
AU  - Johnson AD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - AANA J
JT  - AANA journal
JID - 0431420
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Antidepressive Agents)
RN  - 0 (Centella asiatica extract)
RN  - 0 (Pentacyclic Triterpenes)
RN  - 0 (Plant Extracts)
RN  - 0 (Plant Preparations)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Triterpenes)
RN  - 40P7XK9392 (Flumazenil)
RN  - 9PA5A687X5 (asiatic acid)
RN  - R60L0SM5BC (Midazolam)
MH  - Animals
MH  - Anti-Anxiety Agents/*pharmacology
MH  - Antidepressive Agents/*pharmacology
MH  - Anxiety/drug therapy
MH  - Centella/chemistry
MH  - Depression/drug therapy
MH  - Disease Models, Animal
MH  - Flumazenil/pharmacology
MH  - Male
MH  - Midazolam/pharmacology
MH  - Pentacyclic Triterpenes/*pharmacology
MH  - *Phytotherapy
MH  - Plant Extracts
MH  - Plant Preparations/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, GABA-A/*drug effects
MH  - Triterpenes/*pharmacology
EDAT- 2015/05/29 06:00
MHDA- 2015/07/03 06:00
CRDT- 2015/05/29 06:00
PHST- 2015/05/29 06:00 [entrez]
PHST- 2015/05/29 06:00 [pubmed]
PHST- 2015/07/03 06:00 [medline]
PST - ppublish
SO  - AANA J. 2015 Apr;83(2):91-8.