PMID- 26016226
OWN - NLM
STAT- MEDLINE
DCOM- 20150726
LR  - 20181202
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 31
IP  - 1
DP  - 2015 Jan
TI  - [Effects of acute cold exposure on pulmonary proinflammatory cytokine of rat].
PG  - 6-9
AB  - OBJECTIVE: To study the effects of acute cold exposure on the inflammation and 
      pathologic injuries in pulmonary of rats, and explore the mechanism induced by 
      cold stress. METHODS: Forty male Wistar rats were randomly divided into five 
      groups(n = 8): control group (23 +/- 2)  degrees C 2.5 h, -25 degrees C 0.5 h group, -25 degrees C 1 h 
      group, -25 degrees C 2 h group and -25 degrees C 2.5 h group. Rats were exposed to cold at -25 degrees C 
      and no wind by keeping them in a low temperature chamber except control group. 
      Rectal temperatures of the rats were measured before and after cold exposure. The 
      morphological changes of pulmonary were observed by the optics microscope. The 
      levels of tumer necrosis factor-alpha(TNF- alpha), interleukin-6 (IL-6) and interleukin-beta 
      (IL-1beta) in lung tissue homogenate were measured by ELISA. RESULTS: Compared to 
      the control group, body core temperatures of the -25 degrees C 1 h group, -25 degrees C2 h group 
      and -25 degrees C 2.5 h group were decreased significantly, and the D-values of rectal 
      temperature were increased before and after cold exposure (P < 0.05). The 
      infiltration of inflammatory cells and alveolar edema fluid appeared in the lung 
      tissue of the -25 degrees C 2.5 h group. The concentrations of tumor necrosis factor-alpha 
      (TNF alpha), interleukin-6 (IL-6) and inter- leukin-1beta (IL-1beta) in lung tissue 
      homogenate were increased significantly in -25 degrees C l h group, -25 degrees C 2 h group and 
      -25C degrees  2.5 h group (P < 0. 05). CONCLUSION: The infiltration of inflammatory cells 
      and the increase in proinflammatory cytokine from pulmonary may lead to the lung 
      tissue injury after acute cold exposure.
FAU - Zhang, Ying
AU  - Zhang Y
FAU - Li, Xi
AU  - Li X
FAU - Zhang, Li
AU  - Zhang L
FAU - Lin, Yang-sheng
AU  - Lin YS
FAU - Xiao, Zhong-hai
AU  - Xiao ZH
FAU - Su, Zhuang
AU  - Su Z
FAU - Liu, Ying
AU  - Liu Y
FAU - Yang, Dan-feng
AU  - Yang DF
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Cold Temperature/*adverse effects
MH  - Inflammation/physiopathology
MH  - Interleukin-1beta/*metabolism
MH  - Interleukin-6/*metabolism
MH  - Lung/*metabolism/physiopathology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2015/05/29 06:00
MHDA- 2015/07/28 06:00
CRDT- 2015/05/29 06:00
PHST- 2015/05/29 06:00 [entrez]
PHST- 2015/05/29 06:00 [pubmed]
PHST- 2015/07/28 06:00 [medline]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2015 Jan;31(1):6-9.