PMID- 26016454
OWN - NLM
STAT- MEDLINE
DCOM- 20191212
LR  - 20200225
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 25
IP  - 6
DP  - 2019 Jun
TI  - Xijiao Dihuang Decoction () and Rehmannia glutinosa Libosch. protect mice against 
      lipopolysaccharide and tumor necrosis factor alpha-induced acute liver failure.
PG  - 446-453
LID - 10.1007/s11655-015-2141-2 [doi]
AB  - OBJECTIVE: To investigate the hepatoprotective effect of Xijiao Dihuang Decoction 
      (, XJDHD) on lipopolysaccharide (LPS)- and tumor necrosis factor alpha 
      (TNF-alpha)-induced acute liver failure (ALF) as well as the underlying mechanism of 
      action, and to clarify the key herbs and components of XJDHD. METHODS: 
      LPS/D-galactosamine (D-GalN) or TNF-alpha/D-GalN were intraperitoneally injected into 
      C57BL/6J mice to induce ALF. Simultaneously, XJDHD or its individual herbs and 
      components were orally administered. Survival rates, transaminase levels in 
      serum, and hepatic histology were examined to evaluate the effects of XJDHD. The 
      terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) 
      assay and real-time polymerase chain reaction were additionally performed to 
      expound the mechanism underlying the anti-apoptotic activity of XJDHD. RESULTS: 
      Oral administration of XJDHD protected mice from lethal liver failure induced by 
      LPS and TNF-alpha, with notable amelioration of liver injury in histology and a 
      significant decrease in transaminase levels in serum. XJDHD significantly 
      inhibited apoptosis of hepatocytes and enhanced expression of the antiapoptosis 
      genes, c-Flip, Iap1, Gadd45b and A20. In addition, Rehmannia glutinosa Libosch. 
      was identified as the key herb of XJDHD and galactose as the effective component 
      of Rehmannia glutinosa Libosch. that protects against ALF. CONCLUSIONS: XJDHD 
      inhibits TNF-alpha-induced apoptosis of hepatocytes by promoting the expression of 
      nuclear factor kappa B-regulated anti-apoptotic genes. Rehmannia glutinosa Libosch. 
      is the effective herb of XJDHD and galactose is an active component in this 
      protection.
FAU - Liu, Yan-Min
AU  - Liu YM
AD  - Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical 
      University, Beijing, 100015, China.
FAU - Zhu, Liu-Luan
AU  - Zhu LL
AD  - Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious 
      Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, 
      China.
FAU - Li, Rui
AU  - Li R
AD  - Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious 
      Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, 
      China.
FAU - Zhang, Jin-Liang
AU  - Zhang JL
AD  - Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical 
      University, Beijing, 100015, China.
FAU - Yao, Shan-Shan
AU  - Yao SS
AD  - Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical 
      University, Beijing, 100015, China.
FAU - Zhou, Xiao-Bing
AU  - Zhou XB
AD  - Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical 
      University, Beijing, 100015, China.
FAU - Zeng, Hui
AU  - Zeng H
AD  - Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious 
      Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, 
      China. zenghui@ccmu.edu.cn.
FAU - Wang, Xian-Bo
AU  - Wang XB
AD  - Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical 
      University, Beijing, 100015, China. wangxb@ccmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20150526
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Protective Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (lipopolysaccharide B)
RN  - 7535-00-4 (Galactosamine)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Cytokines/biosynthesis
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Galactosamine
MH  - Hepatocytes/drug effects/pathology
MH  - Lipopolysaccharides
MH  - Liver Failure, Acute/*chemically induced/*drug therapy/pathology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Protective Agents/*therapeutic use
MH  - Rehmannia/*chemistry
MH  - Tumor Necrosis Factor-alpha
OTO - NOTNLM
OT  - Chinese medicine
OT  - Rehmannia glutinosa Libosch.
OT  - Xijiao Dihuang Decoction
OT  - acute liver failure
OT  - lipopolysaccharides
OT  - tumor necrosis factor alpha
EDAT- 2015/05/29 06:00
MHDA- 2019/12/18 06:00
CRDT- 2015/05/29 06:00
PHST- 2014/04/17 00:00 [received]
PHST- 2015/05/29 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2015/05/29 06:00 [entrez]
AID - 10.1007/s11655-015-2141-2 [pii]
AID - 10.1007/s11655-015-2141-2 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2019 Jun;25(6):446-453. doi: 10.1007/s11655-015-2141-2. Epub 
      2015 May 26.