PMID- 26018731
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20220317
IS  - 1554-8635 (Electronic)
IS  - 1554-8627 (Print)
IS  - 1554-8627 (Linking)
VI  - 11
IP  - 7
DP  - 2015
TI  - RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum 
      stress through autophagy.
PG  - 975-94
LID - 10.1080/15548627.2015.1049800 [doi]
AB  - Although RIPK1 (receptor [TNFRSF]-interacting protein kinase 1) is emerging as a 
      critical determinant of cell fate in response to cellular stress resulting from 
      activation of death receptors and DNA damage, its potential role in cell response 
      to endoplasmic reticulum (ER) stress remains undefined. Here we report that RIPK1 
      functions as an important prosurvival mechanism in melanoma cells undergoing 
      pharmacological ER stress induced by tunicamycin (TM) or thapsigargin (TG) 
      through activation of autophagy. While treatment with TM or TG upregulated RIPK1 
      and triggered autophagy in melanoma cells, knockdown of RIPK1 inhibited autophagy 
      and rendered the cells sensitive to killing by TM or TG, recapitulating the 
      effect of inhibition of autophagy. Consistently, overexpression of RIPK1 enhanced 
      induction of autophagy and conferred resistance of melanoma cells to TM- or 
      TG-induced cell death. Activation of MAPK8/JNK1 or MAPK9/JNK2, which 
      phosphorylated BCL2L11/BIM leading to its dissociation from BECN1/Beclin 1, was 
      involved in TM- or TG-induced, RIPK1-mediated activation of autophagy; whereas, 
      activation of the transcription factor HSF1 (heat shock factor protein 1) 
      downstream of the ERN1/IRE1-XBP1 axis of the unfolded protein response was 
      responsible for the increase in RIPK1 in melanoma cells undergoing 
      pharmacological ER stress. Collectively, these results identify upregulation of 
      RIPK1 as an important resistance mechanism of melanoma cells to TM- or TG-induced 
      ER stress by protecting against cell death through activation of autophagy, and 
      suggest that targeting the autophagy-activating mechanism of RIPK1 may be a 
      useful strategy to enhance sensitivity of melanoma cells to therapeutic agents 
      that induce ER stress.
FAU - Luan, Qi
AU  - Luan Q
AD  - a School of Biomedical Sciences and Pharmacy; University of Newcastle ; NSW , 
      Australia.
FAU - Jin, Lei
AU  - Jin L
FAU - Jiang, Chen Chen
AU  - Jiang CC
FAU - Tay, Kwang Hong
AU  - Tay KH
FAU - Lai, Fritz
AU  - Lai F
FAU - Liu, Xiao Ying
AU  - Liu XY
FAU - Liu, Yi Lun
AU  - Liu YL
FAU - Guo, Su Tang
AU  - Guo ST
FAU - Li, Chun Ying
AU  - Li CY
FAU - Yan, Xu Guang
AU  - Yan XG
FAU - Tseng, Hsin-Yi
AU  - Tseng HY
FAU - Zhang, Xu Dong
AU  - Zhang XD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Autophagy
JT  - Autophagy
JID - 101265188
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (BCL2L11 protein, human)
RN  - 0 (BECN1 protein, human)
RN  - 0 (Bcl-2-Like Protein 11)
RN  - 0 (Beclin-1)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Endoplasmic Reticulum Chaperone BiP)
RN  - 0 (HSF1 protein, human)
RN  - 0 (HSPA5 protein, human)
RN  - 0 (Heat Shock Transcription Factors)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Regulatory Factor X Transcription Factors)
RN  - 0 (Transcription Factors)
RN  - 0 (X-Box Binding Protein 1)
RN  - 0 (XBP1 protein, human)
RN  - 11089-65-9 (Tunicamycin)
RN  - 67526-95-8 (Thapsigargin)
RN  - EC 2.7.1.24 (Mitogen-Activated Protein Kinase 9)
RN  - EC 2.7.11.1 (RIPK1 protein, human)
RN  - EC 2.7.11.1 (Receptor-Interacting Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 8)
SB  - IM
EIN - Autophagy. 2020 Jul;16(7):1361. PMID: 32228212
EIN - Autophagy. 2022 Oct;18(10):2514. PMID: 35188064
MH  - Apoptosis/drug effects
MH  - Apoptosis Regulatory Proteins
MH  - *Autophagy/drug effects
MH  - Bcl-2-Like Protein 11
MH  - Beclin-1
MH  - Cell Line, Tumor
MH  - Cell Survival/drug effects
MH  - Cytoprotection/drug effects
MH  - DNA-Binding Proteins/metabolism
MH  - Endoplasmic Reticulum Chaperone BiP
MH  - *Endoplasmic Reticulum Stress/drug effects
MH  - Enzyme Activation/drug effects
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Heat Shock Transcription Factors
MH  - Humans
MH  - Melanoma/*enzymology/genetics/*pathology
MH  - Membrane Proteins
MH  - Mitogen-Activated Protein Kinase 8/metabolism
MH  - Mitogen-Activated Protein Kinase 9/metabolism
MH  - Models, Biological
MH  - Phosphorylation/drug effects
MH  - Proto-Oncogene Proteins
MH  - Receptor-Interacting Protein Serine-Threonine Kinases/genetics/*metabolism
MH  - Regulatory Factor X Transcription Factors
MH  - Thapsigargin/pharmacology
MH  - Transcription Factors/metabolism
MH  - Tunicamycin/pharmacology
MH  - Up-Regulation/drug effects
MH  - X-Box Binding Protein 1
PMC - PMC4590596
OTO - NOTNLM
OT  - 3-MA, 3-methyladenine
OT  - AMPK, AMP-activated protein kinase
OT  - ATF6, activating transcription factor 6
OT  - Baf A1, bafilomycin A1
OT  - CAMKK2, calcium/calmodulin-dependent protein kinase kinase 2: beta
OT  - EIF2AK3/PERK, eukaryotic translation initiation factor 2-alpha kinase 3
OT  - ER, endoplasmic reticulum
OT  - ERN1/IRE1, endoplasmic reticulum to nucleus signaling 1
OT  - HSF1, heat shock transcription factor 1
OT  - HSPA5, heat shock 70kDa protein 5 (glucose-regulated protein: 78kDa)
OT  - MAP2K1/MEK1, mitogen-activated protein kinase kinase 1
OT  - MAPK, mitogen-activated protein kinase
OT  - MAPK1/ERK2, mitogen-activated protein kinase 1
OT  - MAPK11/p38beta, mitogen-activated protein kinase 11
OT  - MAPK12/p38gamma, mitogen-activated protein kinase 12
OT  - MAPK13/p38delta, mitogen-activated protein kinase 13
OT  - MAPK14/p38alpha, mitogen-activated protein kinase 14
OT  - MAPK3/ERK1, mitogen-activated protein kinase 3
OT  - MAPK8/JNK1, mitogen-activated protein kinase 8
OT  - MAPK9/JNK2, mitogen-activated protein kinase 9
OT  - NFKB1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
OT  - PRKAA1, protein kinase AMP-activated: alpha 1 catalytic subunit
OT  - RIPK1
OT  - RIPK1, receptor (TNFRSF)-interacting protein kinase 1
OT  - SQSTM1/p62, sequestosome 1
OT  - TG, thapsigargin
OT  - TM, tunicamycin
OT  - TNFRSF1A/TNFR1, tumor necrosis factor receptor superfamily: member 1A
OT  - UPR, unfolded protein response
OT  - XBP1, x-box binding protein 1
OT  - autophagy
OT  - cell death
OT  - endoplasmic reticulum stress
OT  - melanoma
EDAT- 2015/05/29 06:00
MHDA- 2016/04/19 06:00
PMCR- 2016/02/03
CRDT- 2015/05/29 06:00
PHST- 2015/05/29 06:00 [entrez]
PHST- 2015/05/29 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
PHST- 2016/02/03 00:00 [pmc-release]
AID - 1049800 [pii]
AID - 10.1080/15548627.2015.1049800 [doi]
PST - ppublish
SO  - Autophagy. 2015;11(7):975-94. doi: 10.1080/15548627.2015.1049800.