PMID- 26019469
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20240109
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 21
IP  - 19
DP  - 2015 May 21
TI  - Association of type 2 diabetes mellitus and the risk of colorectal cancer: A 
      meta-analysis and systematic review.
PG  - 6026-31
LID - 10.3748/wjg.v21.i19.6026 [doi]
AB  - AIM: To provide a quantitative assessment of the association between type 2 
      diabetes mellitus (T2DM) and the risk of colorectal cancer (CRC). METHODS: 
      Systematic review was conducted thorough MEDLINE, EMBASE, Cochrane Library, and 
      ISI Web of knowledge databases till 31(st) January 2014. This meta-analysis 
      included the cohort studies that illustrated relative risk (RR) or odds ratio 
      estimates with 95%CI for the predictive risk of CRC by T2DM. Summary relative 
      risks with 95%CI were analyzed by using an effects summary ratio model. 
      Heterogeneity among studies was assessed by the Cochran's Q and I (2) statistics. 
      RESULTS: The meta analysis of 8 finally selected studies showed a positive 
      correlation of T2DM with the risk of CRC as depicted by effects summary RR of 
      1.21 (95%CI: 1.02-1.42). Diabetic women showed greater risk of developing CRC as 
      their effect summary RR of 1.22 (95%CI: 1.01-49) with significant overall Z test 
      at 5% level of significance was higher than the effect summary RR of 1.17 (95%CI: 
      1.00-1.37) of men showing insignificant Z test. The effect summary RR of 1.19 
      with 95%CI of 1.07-1.33 indicate a positive relationship between DM and increased 
      risk of CRC with significant heterogeneity (I (2) = 92% and P-value < 0.05). 
      CONCLUSION: Results from this systematic review and meta-analysis report that 
      diabetic people have an increased risk of CRC as compared to non-diabetics.
FAU - Guraya, Salman Yousuf
AU  - Guraya SY
AD  - Salman Yousuf Guraya, College of Medicine, Taibah University, Almadinah 
      Almunawwarah 41477, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
MH  - Chi-Square Distribution
MH  - Colorectal Neoplasms/diagnosis/*epidemiology
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sex Factors
PMC - PMC4438039
OTO - NOTNLM
OT  - Cancer statistics
OT  - Colorectal cancer
OT  - Gastrointestinal cancers
OT  - Risk ratio
OT  - Type 2 diabetes mellitus
EDAT- 2015/05/29 06:00
MHDA- 2016/02/03 06:00
PMCR- 2015/05/21
CRDT- 2015/05/29 06:00
PHST- 2014/10/23 00:00 [received]
PHST- 2014/11/26 00:00 [revised]
PHST- 2014/12/16 00:00 [accepted]
PHST- 2015/05/29 06:00 [entrez]
PHST- 2015/05/29 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
PHST- 2015/05/21 00:00 [pmc-release]
AID - 10.3748/wjg.v21.i19.6026 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2015 May 21;21(19):6026-31. doi: 10.3748/wjg.v21.i19.6026.