PMID- 26020370
OWN - NLM
STAT- MEDLINE
DCOM- 20161109
LR  - 20191210
IS  - 1536-4801 (Electronic)
IS  - 0277-2116 (Linking)
VI  - 62
IP  - 2
DP  - 2016 Feb
TI  - ESPGHAN 2012 Guidelines for Coeliac Disease Diagnosis: Validation Through a 
      Retrospective Spanish Multicentric Study.
PG  - 284-91
LID - 10.1097/MPG.0000000000000870 [doi]
AB  - OBJECTIVES: A large retrospective multicentre study was conducted in Spain to 
      evaluate the efficiency of the new European Society for Pediatric 
      Gastroenterology, Hepatology, and Nutrition (ESPGHAN) criteria for the diagnosis 
      of coeliac disease (CD). METHODS: The study protocol was approved by the ethics 
      committee of Hospital Universitari i Politecnic La Fe (Valencia, Spain). The 
      present study included 2177 children (ages 0.6-15.9 years) with small bowel 
      biopsy (SBB) performed for diagnostic purposes (from 2000 to 2009) and with a 
      minimum 2-year follow-up after biopsy. RESULTS: CD was diagnosed in 2126 patients 
      (97.5%) and excluded in 51 (2.5%). Tissue transglutaminase antibodies (TG2A), 
      anti-endomysial antibodies (EMA), and human leukocyte antigen (HLA) were reported 
      in 751 patients, 640 symptomatic and 111 asymptomatic. TG2A levels >10 times the 
      upper limit of normal, plus positive EMA and HLA DQ2 and/or DQ8 haplotypes, were 
      found in 336 symptomatic patients, all of them with final diagnosis of CD. In 65 
      of 69 asymptomatic patients, 65 had confirmed CD and 4 did not have CD. According 
      to the 2012 ESPGHAN guidelines, SBB may have been omitted in 52% of the 
      symptomatic patients with CD with serologic and HLA available data. Gluten 
      challenge was performed in 158 children, 75 of them <2 years at first biopsy. 
      Only 1 patient in whom according to the new proposed diagnostic criteria gluten 
      challenge would not have been mandatory did not relapse. CONCLUSIONS: Our results 
      support the new ESPGHAN 2012 guidelines for diagnosis of CD can be safely used 
      without the risk of overdiagnosis. A prospective multicentre study is needed to 
      confirm our results.
FAU - Donat, Ester
AU  - Donat E
AD  - *Pediatric Gastroenterology, Hepatology and Nutrition, Hospital Universitari i 
      Politecnic La Fe, Valencia daggerPediatric Gastroenterology, Complejo Hospitalario 
      Universitario de Vigo, Vigo double daggerPediatric Gastroenterology, Hospital Virgen del 
      Camino, Pamplona  section signPediatric Gastroenterology and Nutrtion, Hospital Teresa 
      Herrrera, A Coruna ||Pediatric Gastroenterology, Hospital Universitario Nino 
      Jesus, Madrid  paragraph signPediatric Gastroenterology, Hepatology and Nutrition Unit, 
      Pediatrics Department, Hospital Clinico Universitario de Santiago, Pediatrics 
      Nutrition Research Group-IDIS, Universidad de Santiago de Compostela, Santiago de 
      Compostela #Pediatric Gastroenterology and Nutrition Unit, Hospital 
      Materno-Infantil, Universidad de Las Palmas de Gran Canaria, Las Palmas and CIBER 
      OBN daggerdaggerPediatric Gastroenterology, Hospital Universitari de Sant Joan de Reus, 
      Reus double daggerdouble daggerPediatric Gastroenterology, Hospital Severo Ochoa, Madrid  section sign section signPediatric 
      Gastroenterology, Hospital de Txagorritxu, Vitoria ||||Pediatric 
      Gastroenterology, Hospital Universitario Ntra Sra de Candelaria, Tenerife 
       paragraph sign paragraph signPediatric Gastroenterology, Hospital General de Albacete, Albacete ##Pediatric 
      Gastroenterology, Hospital Clinico Universitario de Valladolid, Valladolid 
      ***Pediatric Gastroenterology Unit, Hospital Donostia, San Sebastian daggerdaggerdaggerPediatric 
      Gastroenterology, Hospital Universitario de Basurto, Bilbao double daggerdouble daggerdouble daggerPediatric 
      Gastroenterology, Hospital Universitario de Fuenlabrada, Madrid  section sign section sign section signPediatric 
      Gastroenterology, Hepatology and Nutrition, Hospital Universitari i Politecnic La 
      Fe, Valencia, Spain.
FAU - Ramos, Jose M
AU  - Ramos JM
FAU - Sanchez-Valverde, Felix
AU  - Sanchez-Valverde F
FAU - Moreno, Ana
AU  - Moreno A
FAU - Martinez, Maria-Jose
AU  - Martinez MJ
FAU - Leis, Rosaura
AU  - Leis R
FAU - Pena-Quintana, Luis
AU  - Pena-Quintana L
FAU - Castillejo, Gemma
AU  - Castillejo G
FAU - Fernandez, Sonia
AU  - Fernandez S
FAU - Garcia, Zurine
AU  - Garcia Z
FAU - Ortigosa, Luis
AU  - Ortigosa L
FAU - Balmaseda, Elena
AU  - Balmaseda E
FAU - Marugan, Jose-Manuel
AU  - Marugan JM
FAU - Eizaguirre, Francisco-Javier
AU  - Eizaguirre FJ
FAU - Lorenzo, Helena
AU  - Lorenzo H
FAU - Barrio, Josefa
AU  - Barrio J
FAU - Ribes-Koninckx, Carmen
AU  - Ribes-Koninckx C
CN  - SEGHNP Working Group on Coeliac Disease
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Validation Study
PL  - United States
TA  - J Pediatr Gastroenterol Nutr
JT  - Journal of pediatric gastroenterology and nutrition
JID - 8211545
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
RN  - 8002-80-0 (Glutens)
SB  - IM
MH  - Adolescent
MH  - Antibodies/*metabolism
MH  - Biopsy
MH  - Celiac Disease/*diagnosis/genetics/immunology/pathology
MH  - Child
MH  - Child, Preschool
MH  - *Diet
MH  - Glutens/*immunology
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Infant
MH  - Intestine, Small/metabolism/*pathology
MH  - Practice Guidelines as Topic
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Societies, Medical
MH  - Spain
FIR - Sanchez, Cesar
IR  - Sanchez C
FIR - Manrique, Oscar
IR  - Manrique O
FIR - Garcia Peris, Monica
IR  - Garcia Peris M
FIR - Juste, Mercedes
IR  - Juste M
FIR - Perez, Cesar
IR  - Perez C
FIR - Ubalde, Eduardo
IR  - Ubalde E
FIR - Gomez, Ma Angeles
IR  - Gomez MA
FIR - Polanco, Isabel
IR  - Polanco I
FIR - Jovani, Carmen
IR  - Jovani C
FIR - Calabuig, Miguel
IR  - Calabuig M
FIR - Salazar, Jose Carlos
IR  - Salazar JC
FIR - Torrecilla, Javier
IR  - Torrecilla J
FIR - Blanco Rodriguez, Miriam
IR  - Blanco Rodriguez M
FIR - Millan, Antonio
IR  - Millan A
FIR - Ferrer, Pablo
IR  - Ferrer P
FIR - Cuadrado, Soraya
IR  - Cuadrado S
FIR - Lopez, Miguel Angel
IR  - Lopez MA
FIR - Garcia-Burriel, Jose I
IR  - Garcia-Burriel JI
FIR - Solar, Alfonso
IR  - Solar A
FIR - Munoz-Codoceo, Rosa Ana
IR  - Munoz-Codoceo RA
FIR - Monasterio, Lydia
IR  - Monasterio L
FIR - Bolonio, Miguel
IR  - Bolonio M
FIR - Masip, Etna
IR  - Masip E
FIR - Rivero, Sonia Maria
IR  - Rivero SM
FIR - Rayo, Ana Isabel
IR  - Rayo AI
FIR - Huald, Idoia
IR  - Huald I
FIR - Alberto, Jose Ramon
IR  - Alberto JR
FIR - Navarro, Inmaculada
IR  - Navarro I
FIR - Calvo, Carmen
IR  - Calvo C
FIR - Chaves, Nuria
IR  - Chaves N
FIR - Anguiano, Izaskun
IR  - Anguiano I
FIR - Herrero, Myriam
IR  - Herrero M
FIR - Tolin, Mar
IR  - Tolin M
FIR - Clemente, Fernando
IR  - Clemente F
FIR - Perez, Ester
IR  - Perez E
FIR - Algar, Marcelina
IR  - Algar M
FIR - Segarra, Rosa
IR  - Segarra R
FIR - Rodriguez, Alejandro
IR  - Rodriguez A
FIR - Espin Jaime, Beatriz
IR  - Espin Jaime B
FIR - Manzano, Ma Jose
IR  - Manzano MJ
FIR - Romero, Julio
IR  - Romero J
FIR - Maldonado Lozano, Jose
IR  - Maldonado Lozano J
FIR - Martinon Torres, Nazareth
IR  - Martinon Torres N
FIR - Pavon, Pilar
IR  - Pavon P
EDAT- 2015/05/29 06:00
MHDA- 2016/11/10 06:00
CRDT- 2015/05/29 06:00
PHST- 2015/05/29 06:00 [entrez]
PHST- 2015/05/29 06:00 [pubmed]
PHST- 2016/11/10 06:00 [medline]
AID - 10.1097/MPG.0000000000000870 [doi]
PST - ppublish
SO  - J Pediatr Gastroenterol Nutr. 2016 Feb;62(2):284-91. doi: 
      10.1097/MPG.0000000000000870.