PMID- 26021505
OWN - NLM
STAT- MEDLINE
DCOM- 20160315
LR  - 20220316
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 128
IP  - 11
DP  - 2015 Jun 5
TI  - Clinical Characteristics and Prognosis of End-stage Hypertrophic Cardiomyopathy.
PG  - 1483-9
LID - 10.4103/0366-6999.157656 [doi]
AB  - BACKGROUND: End-stage hypertrophic cardiomyopathy (HCM) is complicated by 
      substantial adverse events. However, few studies have focused on 
      electrocardiographic features and their prognostic values in HCM. This study 
      aimed to evaluate the clinical manifestations and prognostic value of 
      electrocardiography in patients with end-stage HCM. METHODS: End-stage HCM 
      patients were enrolled from a total of 1844 consecutive HCM patients from April 
      2002 to November 2013 at Fuwai Hospital. Clinical data, including medical 
      history, electrocardiography, and echocardiography, were analyzed. Cox hazards 
      regression analysis was used to assess the risk factors for cardiovascular 
      mortality. RESULTS: End-stage HCM was identified in 99 (5.4%) patients, averaged 
      at 52 +/- 16 years old at entry. Atrial fibrillation was observed in 53 patients 
      and mural thrombus in 19 patients. During 3.9 +/- 3.0 years of follow-up, embolic 
      stroke, refractory heart failure, and death or transplantation were observed in 
      20, 39, and 51 patients, respectively. The incidence of annual mortality was 
      13.2%. Multivariate Cox hazards regression analysis identified New York Heart 
      Association Class (NYHA) III/IV at entry (hazard ratio [HR]: 1.99; 95% confidence 
      interval [CI]: 1.05-3.80; P = 0.036), left bundle branch block (LBBB) (HR: 2.80; 
      95% CI: 1.47-5.31; P = 0.002), and an abnormal Q wave (HR: 2.21; 95% CI: 
      1.16-4.23; P = 0.016) as independent predictors of cardiovascular death, in 
      accordance with all-cause death and heart failure-related death. CONCLUSIONS: 
      LBBB and an abnormal Q wave are risk factors of cardiovascular mortality in 
      end-stage HCM and provide new evidence for early intervention. Susceptibility of 
      end-stage HCM patients to mural thrombus and embolic events warrants further 
      attention.
FAU - Xiao, Yan
AU  - Xiao Y
FAU - Yang, Kun-Qi
AU  - Yang KQ
FAU - Yang, Yan-Kun
AU  - Yang YK
FAU - Liu, Ya-Xin
AU  - Liu YX
FAU - Tian, Tao
AU  - Tian T
FAU - Song, Lei
AU  - Song L
FAU - Jiang, Xiong-Jing
AU  - Jiang XJ
FAU - Zhou, Xian-Liang
AU  - Zhou XL
AD  - Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai 
      Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing 100037, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiomyopathy, Hypertrophic/diagnostic imaging/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Radiography
MH  - Risk Factors
MH  - Young Adult
PMC - PMC4733774
COIS- Conflict of Interest: None declared.
EDAT- 2015/05/30 06:00
MHDA- 2016/03/16 06:00
PMCR- 2015/06/05
CRDT- 2015/05/30 06:00
PHST- 2015/05/30 06:00 [entrez]
PHST- 2015/05/30 06:00 [pubmed]
PHST- 2016/03/16 06:00 [medline]
PHST- 2015/06/05 00:00 [pmc-release]
AID - ChinMedJ_2015_128_11_1483_157656 [pii]
AID - CMJ-128-1483 [pii]
AID - 10.4103/0366-6999.157656 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2015 Jun 5;128(11):1483-9. doi: 10.4103/0366-6999.157656.