PMID- 26022021
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 26
IP  - 3
DP  - 2015 May-Jun
TI  - Urinary monocyte chemoattractant protein-1 as a biomarker of lupus nephritis 
      activity in children.
PG  - 507-15
LID - 10.4103/1319-2442.157350 [doi]
AB  - Systemic lupus erythematosus (SLE) is a life-long, life-limiting and 
      multi-systemic autoimmune disease. Glomerulonephritis is one of the most serious 
      manifestations of SLE. Younger children have an increased incidence, severity and 
      morbidity of lupus nephritis (LN) compared with adult-onset disease. Monocyte 
      chemoattractant protein-1 (MCP-1) enhances leukocyte adhesiveness and endothelial 
      permeability in the kidneys of murine and human LN models. Our study aimed to 
      assess the role of urinary MCP-1 in the early diagnosis of LN activity. Sixty 
      children, of whom 45 children aged from six to 12 years old and of both sexes (15 
      SLE patients without nephritis, 15 active LN and 15 inactive LN) fulfilling the 
      American College of Rheumatology Classification Criteria for SLE were studied in 
      comparison with 15 healthy subjects. We investigated the serum and urinary MCP-1 
      in all groups using the enzyme-linked immunosorbent assay test. Urinary MCP-1 was 
      significantly higher in active LN in comparison with inactive LN and controls, 
      and also significantly higher in inactive LN in comparison with SLE without 
      nephritis and controls. There was also a significant difference between SLE 
      without nephritis and controls. Serum MCP-1 was significantly higher in the group 
      with active LN in comparison with the inactive group and SLE without nephritis 
      and controls, but there was no significant difference between SLE and controls. 
      The urinary MCP-1 level correlated well with SLE disease activity as measured by 
      the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Urinary MCP-1 
      correlates positively with proteinuria, blood urea nitrogen level and creatinine 
      and negatively with hemoglobin and creatinine clearance. We concluded that 
      measurement of MCP-1 in urine may be useful for monitoring the severity of renal 
      involvement in SLE. We recommend measuring urinary MCP-1 in pediatric SLE for the 
      early diagnosis of LN and for the evaluation of the severity of renal 
      involvement.
FAU - Ghobrial, Emad E
AU  - Ghobrial EE
AD  - Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
FAU - El Hamshary, Azza A
AU  - El Hamshary AA
FAU - Mohamed, Ashraf G
AU  - Mohamed AG
FAU - Abd El Raheim, Yomna A
AU  - Abd El Raheim YA
FAU - Talaat, Ahmed A
AU  - Talaat AA
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of 
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
SB  - IM
EDAT- 2015/05/30 06:00
MHDA- 2015/05/30 06:01
CRDT- 2015/05/30 06:00
PHST- 2015/05/30 06:00 [entrez]
PHST- 2015/05/30 06:00 [pubmed]
PHST- 2015/05/30 06:01 [medline]
AID - SaudiJKidneyDisTranspl_2015_26_3_507_157350 [pii]
AID - 10.4103/1319-2442.157350 [doi]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2015 May-Jun;26(3):507-15. doi: 
      10.4103/1319-2442.157350.