PMID- 26022073
OWN - NLM
STAT- MEDLINE
DCOM- 20160328
LR  - 20181202
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 101
DP  - 2015 Aug
TI  - Expression of Toll-like receptor signaling-related genes in pigs co-infected with 
      porcine reproductive and respiratory syndrome virus and porcine circovirus type 
      2.
PG  - 180-6
LID - S0034-5288(15)00151-4 [pii]
LID - 10.1016/j.rvsc.2015.05.006 [doi]
AB  - Pigs co-infected with porcine reproductive and respiratory syndrome virus (PRRSV) 
      and porcine circovirus type 2 (PCV2) have been shown to develop more severe 
      diseases than pigs infected with PRRSV or PCV2 only. The underlying interaction 
      mechanisms between the two viruses in developing the disease are unclear. The 
      present study investigates the mRNA expression of Toll-like receptor (TLR) 
      signaling-related molecules in peripheral blood mononuclear cells from pigs 
      infected with PRRSV or PCV2 or both. The mRNA expression levels were determined 
      by quantitative real-time RT-PCR. Co-infection of pigs with PRRSV and PCV2 
      resulted in a negatively synergistic effect on the mRNA expression of the 
      negative regulators of TLR, including A20, Bcl-3, IRAK-M, MKP-1, SARM1 and 
      SIGIRR, as well as the TLR downstream transcription factors IRF-1 and IRF-3. A 
      positively synergistic effect of a combined infection of PRRSV and PCV2 on the 
      CD14 mRNA expression was also observed.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Dong, Van Hieu
AU  - Dong VH
AD  - Department of Veterinary Medicine, National Pingtung University of Science and 
      Technology, Neipu, Pingtung 912, Taiwan, ROC.
FAU - Tu, Pang-Yan
AU  - Tu PY
AD  - Department of Veterinary Medicine, National Pingtung University of Science and 
      Technology, Neipu, Pingtung 912, Taiwan, ROC.
FAU - Tsai, Pei-Chun
AU  - Tsai PC
AD  - Department of Veterinary Medicine, National Pingtung University of Science and 
      Technology, Neipu, Pingtung 912, Taiwan, ROC.
FAU - Lin, Yi-Hsin
AU  - Lin YH
AD  - Department of Veterinary Medicine, National Pingtung University of Science and 
      Technology, Neipu, Pingtung 912, Taiwan, ROC.
FAU - Chang, Hsiu-Luan
AU  - Chang HL
AD  - Department of Animal Science, National Pingtung University of Science and 
      Technology, Neipu, Pingtung 912, Taiwan, ROC.
FAU - Kuo, Tsun-Yung
AU  - Kuo TY
AD  - Department of Biotechnology and Animal Science, National Ilan University, Ilan 
      26041, Taiwan, ROC.
FAU - Chiou, Ming-Tang
AU  - Chiou MT
AD  - Department of Veterinary Medicine, National Pingtung University of Science and 
      Technology, Neipu, Pingtung 912, Taiwan, ROC.
FAU - Lin, Chao-Nan
AU  - Lin CN
AD  - Department of Veterinary Medicine, National Pingtung University of Science and 
      Technology, Neipu, Pingtung 912, Taiwan, ROC. Electronic address: 
      cnlin6@mail.npust.edu.tw.
FAU - Chung, Wen-Bin
AU  - Chung WB
AD  - Department of Veterinary Medicine, National Pingtung University of Science and 
      Technology, Neipu, Pingtung 912, Taiwan, ROC. Electronic address: 
      wbchung@mail.npust.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150521
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Antibodies, Viral)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Circovirus/*genetics
MH  - Coinfection/virology
MH  - Gene Expression Regulation/*genetics
MH  - Leukocytes, Mononuclear/metabolism
MH  - Porcine Reproductive and Respiratory Syndrome/*metabolism
MH  - Porcine respiratory and reproductive syndrome virus/*genetics
MH  - Real-Time Polymerase Chain Reaction/veterinary
MH  - Reverse Transcriptase Polymerase Chain Reaction/veterinary
MH  - Signal Transduction/*genetics
MH  - Sus scrofa
MH  - Swine
MH  - Swine Diseases/metabolism/*virology
MH  - Toll-Like Receptors/genetics/*metabolism
OTO - NOTNLM
OT  - Co-infection
OT  - Porcine circovirus type 2
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Signaling-related molecules
OT  - Toll-like receptors
EDAT- 2015/05/30 06:00
MHDA- 2016/03/29 06:00
CRDT- 2015/05/30 06:00
PHST- 2015/01/06 00:00 [received]
PHST- 2015/04/16 00:00 [revised]
PHST- 2015/05/10 00:00 [accepted]
PHST- 2015/05/30 06:00 [entrez]
PHST- 2015/05/30 06:00 [pubmed]
PHST- 2016/03/29 06:00 [medline]
AID - S0034-5288(15)00151-4 [pii]
AID - 10.1016/j.rvsc.2015.05.006 [doi]
PST - ppublish
SO  - Res Vet Sci. 2015 Aug;101:180-6. doi: 10.1016/j.rvsc.2015.05.006. Epub 2015 May 
      21.