PMID- 26022533
OWN - NLM
STAT- MEDLINE
DCOM- 20160119
LR  - 20220321
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Print)
IS  - 1478-6354 (Linking)
VI  - 17
IP  - 1
DP  - 2015 May 28
TI  - Salivary gland ultrasonography: a highly specific tool for the early diagnosis of 
      primary Sjogren's syndrome.
PG  - 146
LID - 10.1186/s13075-015-0657-7 [doi]
LID - 146
AB  - INTRODUCTION: Recently, a great interest has arisen for salivary gland 
      ultrasonography (SGUS) as a valuable tool for the assessment of major salivary 
      gland involvement in primary Sjogren's syndrome (pSS. The aims of this study were 
      to test the accuracy of SGUS for the early detection of pSSand to compare the 
      diagnostic performance of SGUS with minor salivary gland biopsy (MSGB) and 
      unstimulated salivary flow (USFR) in this context. METHOD: Patients with 
      suspected pSS and symptoms duration of </=5 years were consecutively enrolled in 
      this study. The diagnosis of pSS was made according to the AECG criteria. SGUS 
      was performed by two radiologists blinded to the diagnosis and a previously 
      reported ultrasound scoring system (De Vita et al. 1992, cut-off >/= 1) was used to 
      grade the echostructure alterations of the salivary glands. Statistical analysis 
      was performed using SPSS v16. RESULTS: This study included 50 pSS patients and 57 
      controls with no-SS sicca symptoms. The mean(SD) age of the pSS group was lower 
      than non-SS group (47(13) vs 53(12)yrs, p = 0.006). No further differences 
      between the two groups were observed. Patients with pSS showed a significantly 
      higher SGUS score in comparison with controls (mean(SD) = 2.1(1.8) vs 0.0(0.4), p 
      = 0.000). The SGUS cut-off >/= 1 showed a sensitivity (SE) of 66 %, a specificity 
      (SP) of 98 %, a positive predictive value (PPV) of 97 % and a negative predictive 
      value (NPV) of 73 % for pSS diagnosis. The SGUS score correlated also with 
      patients' MSGB/FS and USFR. CONCLUSIONS: This study confirmed the good 
      performance of SGUS for the early non-invasive diagnosis of pSS. Further research 
      in larger international cohort of patients is mandatory in order to assess the 
      role of SGUS in the diagnostic algorithm of pSS.
FAU - Baldini, Chiara
AU  - Baldini C
AD  - Rheumatology Unit, University of Pisa, Via Roma, 67, 56126, Pisa, Italy. 
      chiara.baldini74@gmail.com.
FAU - Luciano, Nicoletta
AU  - Luciano N
AD  - Rheumatology Unit, University of Pisa, Via Roma, 67, 56126, Pisa, Italy. 
      nicoletta.luciano83@gmail.com.
FAU - Tarantini, Gaia
AU  - Tarantini G
AD  - Radiology Unit, University of Pisa, Pisa, Italy. pisagaia@hotmail.it.
FAU - Pascale, Rachele
AU  - Pascale R
AD  - Radiology Unit, University of Pisa, Pisa, Italy. rachelepascale@gmail.com.
FAU - Sernissi, Francesca
AU  - Sernissi F
AD  - Rheumatology Unit, University of Pisa, Via Roma, 67, 56126, Pisa, Italy. 
      francesca.sernissi@for.unipi.it.
FAU - Mosca, Marta
AU  - Mosca M
AD  - Rheumatology Unit, University of Pisa, Via Roma, 67, 56126, Pisa, Italy. 
      marta.mosca@med.unipi.it.
FAU - Caramella, Davide
AU  - Caramella D
AD  - Radiology Unit, University of Pisa, Pisa, Italy. davide.caramella@med.unipi.it.
FAU - Bombardieri, Stefano
AU  - Bombardieri S
AD  - Rheumatology Unit, University of Pisa, Via Roma, 67, 56126, Pisa, Italy. 
      s.bombardieri@int.med.unipi.it.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150528
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
SB  - IM
MH  - Adult
MH  - Biopsy, Needle
MH  - Case-Control Studies
MH  - *Early Diagnosis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Salivary Glands/*diagnostic imaging/pathology
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Sjogren's Syndrome/diagnosis/*diagnostic imaging/pathology
MH  - Statistics, Nonparametric
MH  - Ultrasonography, Doppler/*methods
PMC - PMC4461980
EDAT- 2015/05/30 06:00
MHDA- 2016/01/20 06:00
PMCR- 2015/05/28
CRDT- 2015/05/30 06:00
PHST- 2014/09/28 00:00 [received]
PHST- 2015/05/18 00:00 [accepted]
PHST- 2015/05/30 06:00 [entrez]
PHST- 2015/05/30 06:00 [pubmed]
PHST- 2016/01/20 06:00 [medline]
PHST- 2015/05/28 00:00 [pmc-release]
AID - 10.1186/s13075-015-0657-7 [pii]
AID - 657 [pii]
AID - 10.1186/s13075-015-0657-7 [doi]
PST - epublish
SO  - Arthritis Res Ther. 2015 May 28;17(1):146. doi: 10.1186/s13075-015-0657-7.