PMID- 26022612
OWN - NLM
STAT- MEDLINE
DCOM- 20160324
LR  - 20220408
IS  - 1421-9735 (Electronic)
IS  - 0253-5068 (Linking)
VI  - 39
IP  - 4
DP  - 2015
TI  - Incidence of Adverse Events during Continuous Renal Replacement Therapy.
PG  - 333-9
LID - 10.1159/000380903 [doi]
AB  - BACKGROUND/AIMS: The incidence of adverse events (AEs) in adults who receive 
      continuous renal replacement therapy (CRRT) is unknown. We report the incidence 
      of mechanical, metabolic, and hemodynamic CRRT AEs. METHODS: This is a 
      retrospective study of all consecutive adult patients (>/=18 years) who underwent 
      CRRT from January 1, 2007 to December 31, 2009. RESULTS: Out of 595 patients who 
      underwent CRRT, 366 (62%) were male and 500 (84%) were Caucasian. Regional 
      citrate anticoagulation was used in 98.6% of all patients. The most common 
      clinically significant electrolyte derangements were ionized hypocalcemia (22%), 
      ionized hypercalcemia (23%), and hyperphosphatemia (44%). Almost all (97%) 
      patients had at least one additional AE including new onset hypotension (within 
      the first hour after CRRT initiation) (43%), hypothermia (44%), new onset 
      arrhythmias (29%), new onset anemia (31%) and thrombocytopenia (40%). 
      CONCLUSIONS: ICU patients who require CRRT have a high incidence of AEs. Although 
      the extent to which these complications are attributable to CRRT is not known, 
      clinicians need to be cautious and aware of their high prevalence in this patient 
      population.
CI  - (c) 2015 S. Karger AG, Basel.
FAU - Akhoundi, Abbasali
AU  - Akhoundi A
AD  - Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo 
      Clinic, Rochester, Minn., USA.
FAU - Singh, Balwinder
AU  - Singh B
FAU - Vela, Myriam
AU  - Vela M
FAU - Chaudhary, Sanjay
AU  - Chaudhary S
FAU - Monaghan, Myles
AU  - Monaghan M
FAU - Wilson, Gregory A
AU  - Wilson GA
FAU - Dillon, John J
AU  - Dillon JJ
FAU - Cartin-Ceba, Rodrigo
AU  - Cartin-Ceba R
FAU - Lieske, John C
AU  - Lieske JC
FAU - Gajic, Ognjen
AU  - Gajic O
FAU - Kashani, Kianoush
AU  - Kashani K
LA  - eng
PT  - Journal Article
DEP - 20150522
PL  - Switzerland
TA  - Blood Purif
JT  - Blood purification
JID - 8402040
SB  - IM
MH  - Acute Kidney Injury/*complications/diagnosis/*epidemiology/etiology/therapy
MH  - Aged
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Renal Replacement Therapy/*adverse effects/methods
MH  - Retrospective Studies
MH  - Severity of Illness Index
EDAT- 2015/05/30 06:00
MHDA- 2016/03/25 06:00
CRDT- 2015/05/30 06:00
PHST- 2014/08/14 00:00 [received]
PHST- 2015/02/12 00:00 [accepted]
PHST- 2015/05/30 06:00 [entrez]
PHST- 2015/05/30 06:00 [pubmed]
PHST- 2016/03/25 06:00 [medline]
AID - 000380903 [pii]
AID - 10.1159/000380903 [doi]
PST - ppublish
SO  - Blood Purif. 2015;39(4):333-9. doi: 10.1159/000380903. Epub 2015 May 22.