PMID- 26022959
OWN - NLM
STAT- MEDLINE
DCOM- 20160603
LR  - 20191210
IS  - 1399-3003 (Electronic)
IS  - 0903-1936 (Linking)
VI  - 46
IP  - 3
DP  - 2015 Sep
TI  - Outcomes of beta-blocker use in pulmonary arterial hypertension: a 
      propensity-matched analysis.
PG  - 750-60
LID - 10.1183/09031936.00215514 [doi]
AB  - The utility and safety of beta-blockers in pulmonary hypertension is controversial. 
      Anecdotal reports suggest that beta-blockers may be harmful in these patients. The 
      aim of our study was to evaluate outcomes of beta-blocker use in pulmonary 
      hypertension.We reviewed patients from our pulmonary hypertension registry 
      between 2000 and 2011. Patients who continued to use beta-blockers were compared to 
      those who never used beta-blockers for all-cause mortality, time to clinical 
      worsening events, defined as death, lung transplantation and hospitalisation due 
      to pulmonary hypertension. We also evaluated the effect of beta-blockers on 6-min 
      walking distance and New York Heart Association (NYHA) functional class.133 
      patients used beta-blockers and 375 patients never used beta-blockers. Mean+/-sd age was 
      57+/-16 years and the median follow-up period was 78 months. Propensity-matched 
      analysis showed that the adjusted odds ratio (95% CI) for mortality with 
      beta-blocker use was 1.13 (0.69-1.82) and for clinical worsening events was 0.96 
      (0.55-1.68). No significant difference was noted in probability of survival and 
      time to clinical worsening events. Patients on beta-blockers walked a shorter 
      distance on follow-up 6 min walk test; follow-up NYHA class was similar between 
      groups.Pulmonary hypertension patients receiving beta-blockers had a similar 
      survival and time to clinical worsening events compared to patients not receiving 
      them. Functional outcomes were similar, although beta-blocker use was associated 
      with a tendency towards shorter walking distance.
CI  - Copyright (c)ERS 2015.
FAU - Bandyopadhyay, Debabrata
AU  - Bandyopadhyay D
AD  - Dept of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, 
      Cleveland Clinic, Cleveland, OH, USA.
FAU - Bajaj, Navkaranbir S
AU  - Bajaj NS
AD  - Dept of Cardiovascular Medicine, University of Alabama, Birmingham, AL, USA.
FAU - Zein, Joe
AU  - Zein J
AD  - Dept of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, 
      Cleveland Clinic, Cleveland, OH, USA.
FAU - Minai, Omar A
AU  - Minai OA
AD  - Dept of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, 
      Cleveland Clinic, Cleveland, OH, USA.
FAU - Dweik, Raed A
AU  - Dweik RA
AD  - Dept of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, 
      Cleveland Clinic, Cleveland, OH, USA dweikr@ccf.org.
LA  - eng
GR  - P01HL107147/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150528
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Adrenergic beta-Antagonists)
SB  - IM
CIN - Eur Respir J. 2015 Sep;46(3):619-21. PMID: 26324694
CIN - Eur Respir J. 2016 Feb;47(2):682-4. PMID: 26828057
MH  - Adrenergic beta-Antagonists/*adverse effects/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - *Cause of Death
MH  - Confidence Intervals
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/diagnosis/*drug therapy/*mortality
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Pulmonary Wedge Pressure/drug effects
MH  - Reference Values
MH  - Registries
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Survival Analysis
MH  - Treatment Outcome
EDAT- 2015/05/30 06:00
MHDA- 2016/06/04 06:00
CRDT- 2015/05/30 06:00
PHST- 2014/11/21 00:00 [received]
PHST- 2015/03/01 00:00 [accepted]
PHST- 2015/05/30 06:00 [entrez]
PHST- 2015/05/30 06:00 [pubmed]
PHST- 2016/06/04 06:00 [medline]
AID - 09031936.00215514 [pii]
AID - 10.1183/09031936.00215514 [doi]
PST - ppublish
SO  - Eur Respir J. 2015 Sep;46(3):750-60. doi: 10.1183/09031936.00215514. Epub 2015 
      May 28.