PMID- 26023628
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150529
LR  - 20220330
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 9
IP  - 4
DP  - 2015 Apr
TI  - Immunoglobulin e, interleukin-18 and interleukin-12 in patients with atopic 
      dermatitis: correlation with disease activity.
PG  - WC01-5
LID - 10.7860/JCDR/2015/12261.5742 [doi]
AB  - INTRODUCTION: Atopic dermatitis (AD) is a chronic inflammatory skin disorder. 
      Immunological/inflammatory reactions are reported to play a role in AD but their 
      role in disease activity has not been fully investigated. This study was done to 
      investigate the role of immunoglobulin E (IgE), interleukin (IL)-18 and IL-12 in 
      AD patients with different disease severities. MATERIALS AND METHODS: Sera from 
      50 AD infants with varying levels of disease activity according to the scoring 
      index of atopic dermatitis (SCORAD) index and 30 age-matched healthy controls 
      were evaluated for serum levels of IgE, IL-18 and IL-12/p40. RESULTS: Serum 
      analysis showed higher levels of IgE, IL-18 or IL-12/p40 in AD patients compared 
      with controls. Interestingly, not only was there an increased number of subjects 
      positive for IgE, IL-18 or IL-12/p40, but also the levels of these parameters 
      were higher among AD patients whose SCORAD scores were higher. In addition, a 
      significant correlation was observed between the levels of these parameters and 
      SCORAD scores. CONCLUSION: These findings support an association between IgE, 
      IL-18 or IL-12/p40 and AD. The stronger response observed in serum samples from 
      patients with higher SCORAD scores suggest that IgE, IL-18 and IL-12/p40 may be 
      useful in evaluating the progression of AD and in elucidating the mechanisms of 
      disease pathogenesis.
FAU - Zedan, Khaled
AU  - Zedan K
AD  - Assistant Professor, Department of Pediatrics, College of Medicine, Qassim 
      University , Buraidah, Saudi Arabia .
FAU - Rasheed, Zafar
AU  - Rasheed Z
AD  - Assistant Professor, Department of Medical Biochemistry, College of Medicine, 
      Qassim University , Buraidah, Saudi Arabia .
FAU - Farouk, Yaser
AU  - Farouk Y
AD  - Assistant Professor, Department of Pediatrics, College of Medicine, Qassim 
      University , Buraidah, Saudi Arabia .
FAU - Alzolibani, Abdullateef A
AU  - Alzolibani AA
AD  - Associate Professor, Department of Dermatology, College of Medicine, Qassim 
      University , Buraidah, Saudi Arabia .
FAU - Bin Saif, Ghada
AU  - Bin Saif G
AD  - Associate Professor, Department of Dermatology, College of Medicine, King Saud 
      University , Riyadh, Saudi Arabia .
FAU - Ismail, Hisham A
AU  - Ismail HA
AD  - Professor, Department of Pathology, College of Medicine, Qassim University , 
      Buraidah, Saudi Arabia .
FAU - Al Robaee, Ahmad A
AU  - Al Robaee AA
AD  - Professor, Department of Dermatology, College of Medicine, Qassim University , 
      Buraidah, Saudi Arabia .
LA  - eng
PT  - Journal Article
DEP - 20150401
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC4437144
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Disease activity
OT  - Immunoglobulin E
OT  - Interleukin-12
OT  - Interleukin-18
EDAT- 2015/05/30 06:00
MHDA- 2015/05/30 06:01
PMCR- 2015/04/01
CRDT- 2015/05/30 06:00
PHST- 2014/11/24 00:00 [received]
PHST- 2015/02/28 00:00 [accepted]
PHST- 2015/05/30 06:00 [entrez]
PHST- 2015/05/30 06:00 [pubmed]
PHST- 2015/05/30 06:01 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2015/12261.5742 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2015 Apr;9(4):WC01-5. doi: 10.7860/JCDR/2015/12261.5742. Epub 
      2015 Apr 1.