PMID- 26024244
OWN - NLM
STAT- MEDLINE
DCOM- 20160617
LR  - 20221207
IS  - 2191-0251 (Electronic)
IS  - 0334-018X (Linking)
VI  - 28
IP  - 9-10
DP  - 2015 Sep
TI  - Insulin dynamics and biochemical markers for predicting impaired glucose 
      tolerance in obese Thai youth.
PG  - 1039-45
LID - 10.1515/jpem-2014-0273 [doi]
AB  - BACKGROUND: Subjects with impaired glucose tolerance (IGT) are at risk for type 2 
      diabetes mellitus (T2DM) and cardiovascular disease. The predictors of IGT in 
      obese youth are not well described. METHODS: We studied 115 obese Thai children 
      who underwent an oral glucose tolerance test (OGTT). Plasma glucose and insulin 
      levels were calculated for assessment of beta-cell function. Hemoglobin A1c (HbA1c), 
      lipid profile, and clinical parameters were also used to determine predictors of 
      IGT. RESULTS: We found that three patients had T2DM and 30 subjects had IGT. IGT 
      patients had significantly higher fasting glucose (FG), 1-h postload glucose, 2-h 
      postload insulin, and lower whole-body insulin sensitivity indices than in normal 
      glucose tolerance subjects whereas other indices were comparable. By ROC curve 
      analyses, 1-h postload glucose was the best predictor of IGT, but FG or HbA1c 
      represented a poor diagnostic tool for prediabetes screening. Subjects with 1-h 
      OGTT glucose > 155 mg/dL had significantly lower high-density lipoprotein levels, 
      lower insulin sensitivity, and more insulin resistance than those with 1-h 
      postload glucose of </= 155 mg/dL. CONCLUSIONS: Abnormal glucose tolerance is 
      highly prevalent in obese Thai youth. Several fasting indices and HbA1c fail to 
      predict IGT. An 1-h OGTT glucose of > 155 mg/dL appears to be more associated 
      with adverse insulin dynamics and metabolic profile than 2-h postload glucose.
FAU - Tirabanchasak, Sirapassorn
AU  - Tirabanchasak S
FAU - Siripunthana, Sukumarn
AU  - Siripunthana S
FAU - Supornsilchai, Vichit
AU  - Supornsilchai V
FAU - Wacharasindhu, Suttipong
AU  - Wacharasindhu S
FAU - Sahakitrungruang, Taninee
AU  - Sahakitrungruang T
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Child
MH  - Female
MH  - Glucose Intolerance/blood/complications/*diagnosis
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/*metabolism
MH  - Humans
MH  - Insulin/*blood
MH  - Insulin Resistance/physiology
MH  - Lipids/blood
MH  - Male
MH  - Obesity/*blood/complications
MH  - Thailand
EDAT- 2015/05/30 06:00
MHDA- 2016/06/18 06:00
CRDT- 2015/05/30 06:00
PHST- 2014/06/24 00:00 [received]
PHST- 2015/04/13 00:00 [accepted]
PHST- 2015/05/30 06:00 [entrez]
PHST- 2015/05/30 06:00 [pubmed]
PHST- 2016/06/18 06:00 [medline]
AID - /j/jpem.ahead-of-print/jpem-2014-0273/jpem-2014-0273.xml [pii]
AID - 10.1515/jpem-2014-0273 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2015 Sep;28(9-10):1039-45. doi: 
      10.1515/jpem-2014-0273.