PMID- 26024304 OWN - NLM STAT- MEDLINE DCOM- 20160325 LR - 20181113 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 5 DP - 2015 May 29 TI - A variant of PSMD6 is associated with the therapeutic efficacy of oral antidiabetic drugs in Chinese type 2 diabetes patients. PG - 10701 LID - 10.1038/srep10701 [doi] LID - 10701 AB - The PSMD6 variant rs831571 has been identified as a susceptibility locus for type 2 diabetes mellitus (T2DM). This study aimed to investigate the association of this variant with therapeutic effects of oral antidiabetic drugs in Chinese T2DM patients. 209 newly diagnosed T2DM patients were randomly assigned to treatment with repaglinide or rosiglitazone for 48 weeks, and the therapeutic effects were compared. In the rosiglitazone cohort, rs831571 showed significant associations with fasting plasma glucose (FPG), 2-h glucose and decrement of glycated haemoglobin (HbA1c) levels after 24 weeks of treatment (P = 0.0368, 0.0468 and 0.0247, respectively). The C allele was significantly associated with a better attainment of FPG at 24 and 32 weeks (P = 0.0172 and 0.0257, respectively). Survival analyses showed CC homozygotes were more likely to attain a standard FPG level (P = 0.0654). In the repaglinide cohort, rs831571 was significantly associated with decreased HbA1c levels after 24 weeks of treatment, the homeostatic model assessment of insulin resistance and fasting insulin level after 48 weeks of treatment with repaglinide (P = 0.0096, 0235 and 0.0212, respectively). In conclusion, we observed that the PSMD6 variant rs831571 might be associated with the therapeutic effects of rosiglitazone and repaglinide in Chinese T2DM patients. However, these findings need to be confirmed in the future. FAU - Chen, Miao AU - Chen M AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. FAU - Hu, Cheng AU - Hu C AD - 1] Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China [2] Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai, China. FAU - Zhang, Rong AU - Zhang R AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. FAU - Jiang, Feng AU - Jiang F AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. FAU - Wang, Jie AU - Wang J AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. FAU - Peng, Danfeng AU - Peng D AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. FAU - Tang, Shanshan AU - Tang S AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. FAU - Sun, Xue AU - Sun X AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. FAU - Yan, Jing AU - Yan J AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. FAU - Wang, Shiyun AU - Wang S AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. FAU - Wang, Tao AU - Wang T AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. FAU - Bao, Yuqian AU - Bao Y AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. FAU - Jia, Weiping AU - Jia W AD - Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20150529 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Hypoglycemic Agents) RN - 0 (proteasome 26S subunit, non-ATPase 6, human) RN - EC 3.4.25.1 (Proteasome Endopeptidase Complex) SB - IM MH - Administration, Oral MH - Alleles MH - China MH - Cohort Studies MH - Diabetes Mellitus, Type 2/diagnosis/*drug therapy/*genetics MH - Female MH - *Genetic Variation MH - Genotype MH - Humans MH - Hypoglycemic Agents/administration & dosage/*therapeutic use MH - Male MH - Middle Aged MH - Polymorphism, Single Nucleotide MH - Proteasome Endopeptidase Complex/*genetics MH - Risk Factors MH - Treatment Outcome PMC - PMC4448652 EDAT- 2015/05/30 06:00 MHDA- 2016/03/26 06:00 PMCR- 2015/05/29 CRDT- 2015/05/30 06:00 PHST- 2015/01/08 00:00 [received] PHST- 2015/04/27 00:00 [accepted] PHST- 2015/05/30 06:00 [entrez] PHST- 2015/05/30 06:00 [pubmed] PHST- 2016/03/26 06:00 [medline] PHST- 2015/05/29 00:00 [pmc-release] AID - srep10701 [pii] AID - 10.1038/srep10701 [doi] PST - epublish SO - Sci Rep. 2015 May 29;5:10701. doi: 10.1038/srep10701.