PMID- 26024742
OWN - NLM
STAT- MEDLINE
DCOM- 20160526
LR  - 20220310
IS  - 1532-2807 (Electronic)
IS  - 1219-4956 (Linking)
VI  - 21
IP  - 4
DP  - 2015 Sep
TI  - Expression of Amino Acid Transporters (LAT1 and ASCT2) in Patients with Stage 
      III/IV Laryngeal Squamous Cell Carcinoma.
PG  - 1175-81
LID - 10.1007/s12253-015-9954-3 [doi]
AB  - The aim of this study is to evaluate the clinicopathological significance of 
      L-type amino acid transporter 1 (LAT1) expression in patients with advanced 
      laryngeal squamous cell carcinoma (LSCC). A total of 73 patients with advanced 
      LSCC were retrospectively reviewed. Tumor sections were stained by 
      immunohistochemistry for LAT1, 4F2hc, system ASC amino acid transporter-2 
      (ASCT2), cell proliferation by Ki-67, microvessel density (MVD) determined by 
      CD34 and p53. A positive LAT1, 4F2hc and ASCT2 expression (staining more than a 
      quarter) in the primary sites were recognized in 85, 80 and 45 %, respectively, 
      and a high LAT1, 4F2hc and ASCT2 expression (staining more than a half) yielded 
      48, 31 and 18 %, respectively. High expression of LAT1 was significantly 
      associated with lymph node metastasis, 4F2hc, ASCT2, Ki-67 and p53. The 
      expression of LAT1 was significantly correlated with ASCT2, 4F2hc, cell 
      proliferation, and MVD. By univariate analysis, there was no statistically 
      significant relationship between LAT1 expression and prognosis in advanced LSCC. 
      LAT1, 4F2hc and ASCT2 were highly expressed in patients with advanced laryngeal 
      cancer. Our study suggests that the expression of LAT1 plays a crucial role in 
      the metastasis and tumor progression in advanced LSCC.
FAU - Nikkuni, Osamu
AU  - Nikkuni O
AD  - Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate 
      School of Medicine, Maebashi, Japan, nikkuni@gunma-u.ac.jp.
FAU - Kaira, Kyoichi
AU  - Kaira K
FAU - Toyoda, Minoru
AU  - Toyoda M
FAU - Shino, Masato
AU  - Shino M
FAU - Sakakura, Koichi
AU  - Sakakura K
FAU - Takahashi, Katsumasa
AU  - Takahashi K
FAU - Tominaga, Hideyuki
AU  - Tominaga H
FAU - Oriuchi, Noboru
AU  - Oriuchi N
FAU - Suzuki, Masami
AU  - Suzuki M
FAU - Iijima, Misa
AU  - Iijima M
FAU - Asao, Takayuki
AU  - Asao T
FAU - Nishiyama, Masahiko
AU  - Nishiyama M
FAU - Nagamori, Shushi
AU  - Nagamori S
FAU - Kanai, Yoshikatsu
AU  - Kanai Y
FAU - Oyama, Tetsunari
AU  - Oyama T
FAU - Chikamatsu, Kazuaki
AU  - Chikamatsu K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150530
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
RN  - 0 (Amino Acid Transport System ASC)
RN  - 0 (Amino Acid Transport Systems)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Large Neutral Amino Acid-Transporter 1)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (SLC1A5 protein, human)
SB  - IM
MH  - Aged
MH  - Amino Acid Transport System ASC/*genetics
MH  - Amino Acid Transport Systems/*genetics
MH  - Biomarkers, Tumor/genetics
MH  - Carcinoma, Squamous Cell/*genetics/*pathology
MH  - Cell Proliferation/genetics
MH  - Female
MH  - Head and Neck Neoplasms/*genetics/*pathology
MH  - Humans
MH  - Large Neutral Amino Acid-Transporter 1/*genetics
MH  - Laryngeal Neoplasms/*genetics/*pathology
MH  - Lymphatic Metastasis/genetics/pathology
MH  - Male
MH  - Minor Histocompatibility Antigens
MH  - Neoplasm Staging/methods
MH  - Prognosis
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2015/05/31 06:00
MHDA- 2016/05/27 06:00
CRDT- 2015/05/31 06:00
PHST- 2014/05/28 00:00 [received]
PHST- 2015/05/14 00:00 [accepted]
PHST- 2015/05/31 06:00 [entrez]
PHST- 2015/05/31 06:00 [pubmed]
PHST- 2016/05/27 06:00 [medline]
AID - 10.1007/s12253-015-9954-3 [doi]
PST - ppublish
SO  - Pathol Oncol Res. 2015 Sep;21(4):1175-81. doi: 10.1007/s12253-015-9954-3. Epub 
      2015 May 30.