PMID- 26024756
OWN - NLM
STAT- MEDLINE
DCOM- 20151109
LR  - 20221207
IS  - 1532-8600 (Electronic)
IS  - 0026-0495 (Linking)
VI  - 64
IP  - 9
DP  - 2015 Sep
TI  - Irisin-encoding gene (FNDC5) variant is associated with changes in blood pressure 
      and lipid profile in type 2 diabetic women but not in men.
PG  - 952-7
LID - S0026-0495(15)00137-7 [pii]
LID - 10.1016/j.metabol.2015.05.005 [doi]
AB  - INTRODUCTION: Irisin has recently been described as a novel myokine, which 
      reduces visceral obesity and improves glucose metabolism in mice. Thus, 
      polymorphisms in the gene encoding irisin, fibronectin type III domain containing 
      5 (FNDC5), may be associated with type 2 diabetes mellitus (T2DM) and related 
      disorders. However, to date, no study has investigated the association between 
      FNDC5 polymorphisms and susceptibility to T2DM. OBJECTIVE: To investigate the 
      association of FNDC5 rs3480 (A/G) and rs1746661 (G/T) polymorphisms, alone or in 
      combination, with T2DM and its clinical features. METHODS: We analyzed 1006 T2DM 
      patients and 434 nondiabetic subjects. Polymorphisms were genotyped by real-time 
      PCR using TaqMan MGB probes. Haplotypes constructed from the combination of 
      rs1746661 and rs3480 polymorphisms were inferred using the Phase 2.1 program. 
      RESULTS: Genotype, allele and haplotype frequencies of rs1746661 and rs3480 
      polymorphisms did not differ significantly between nondiabetic subjects and T2DM 
      patients. Women with T2DM carrying the G allele of rs3480 showed increased HbA1c 
      levels compared with A/A carriers, adjusted for age. The T allele of rs1746661 
      was associated with increased systolic blood pressure, total cholesterol and 
      LDL-cholesterol and decreased HDL-cholesterol in women with T2DM, adjusted for 
      covariates. Moreover, prevalence of hypercholesterolemia was higher in women 
      carrying the T allele of rs1746661 than in G/G carriers (72.4% vs. 58.7%, 
      OR=2.010, 95% CI=1.210-3.390), but it was not significantly different in men. 
      CONCLUSIONS: These results indicate that, although not associated with T2DM, the 
      G allele of rs3480 appears to be associated with increased HbA1c, while the T 
      allele of rs1746661 appears to be associated with higher systolic blood pressure 
      and dyslipidemia in women with T2DM.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Brondani, Leticia A
AU  - Brondani LA
AD  - Endocrine Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio 
      Grande do Sul, Brazil; Postgraduate Program in Medical Sciences: Endocrinology, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 
      Brazil.
FAU - Boelter, Gabriela
AU  - Boelter G
AD  - Endocrine Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio 
      Grande do Sul, Brazil.
FAU - Assmann, Tais S
AU  - Assmann TS
AD  - Endocrine Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio 
      Grande do Sul, Brazil; Postgraduate Program in Medical Sciences: Endocrinology, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 
      Brazil.
FAU - Leitao, Cristiane B
AU  - Leitao CB
AD  - Endocrine Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio 
      Grande do Sul, Brazil; Postgraduate Program in Medical Sciences: Endocrinology, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 
      Brazil.
FAU - Canani, Luis H
AU  - Canani LH
AD  - Endocrine Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio 
      Grande do Sul, Brazil; Postgraduate Program in Medical Sciences: Endocrinology, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 
      Brazil.
FAU - Crispim, Daisy
AU  - Crispim D
AD  - Endocrine Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio 
      Grande do Sul, Brazil; Postgraduate Program in Medical Sciences: Endocrinology, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, 
      Brazil. Electronic address: dcmoreira@hcpa.edu.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150514
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Aging
MH  - Blood Pressure/*genetics
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/*genetics/*physiopathology
MH  - Female
MH  - Fibronectins/*genetics/*physiology
MH  - Gene Frequency
MH  - Genotype
MH  - Glycated Hemoglobin/metabolism
MH  - Heterozygote
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Lipids/*blood
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/genetics
MH  - Sex Characteristics
OTO - NOTNLM
OT  - Blood pressure
OT  - Dyslipidemia
OT  - FNDC5 gene
OT  - Irisin
OT  - Type 2 diabetes mellitus
EDAT- 2015/05/31 06:00
MHDA- 2015/11/10 06:00
CRDT- 2015/05/31 06:00
PHST- 2014/10/24 00:00 [received]
PHST- 2015/05/05 00:00 [revised]
PHST- 2015/05/08 00:00 [accepted]
PHST- 2015/05/31 06:00 [entrez]
PHST- 2015/05/31 06:00 [pubmed]
PHST- 2015/11/10 06:00 [medline]
AID - S0026-0495(15)00137-7 [pii]
AID - 10.1016/j.metabol.2015.05.005 [doi]
PST - ppublish
SO  - Metabolism. 2015 Sep;64(9):952-7. doi: 10.1016/j.metabol.2015.05.005. Epub 2015 
      May 14.