PMID- 2602493
OWN - NLM
STAT- MEDLINE
DCOM- 19900130
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 46
IP  - 4
DP  - 1989 Oct
TI  - Hepatic vagotomy increases consumption of a novel-tasting diet presented 
      immediately after surgery.
PG  - 671-8
AB  - To further characterize the possible effect of hepatic vagotomy on food intake, 
      rats adapted to a medium-fat diet (MF diet) were offered a novel-tasting diet 
      immediately after hepatic branch vagotomy (HBX rats) or sham vagotomy (SHAM rats) 
      and food intake as well as diet selection (novel-tasting vs. familiar diet) was 
      measured. When a novel-tasting sweet medium-fat diet (SMF diet) was offered 
      immediately after surgery, HBX rats ate transiently more (days 1-4 after surgery) 
      and selected more (days 5 and 6 after surgery) of the SMF diet than SHAM rats. 
      Similar results were obtained when a novel-tasting bitter diet (AMF diet) was 
      offered instead of the SMF diet. In contrast, when rats adapted to the AMF diet 
      prior to surgery were given normal MF diet as novel-tasting diet immediately 
      after surgery, HBX and SHAM rats' postoperative food intake and diet selection 
      did not differ. When rats were given only MF or SMF diet before and after 
      surgery, HBX and SHAM rats' food intake during the initial postoperative period 
      also did not differ. The results indicate that hepatic branch vagotomy and sham 
      vagotomy have different aversive effects which lead to transient differences in 
      postoperative food intake when diets with a novel and strong taste are presented 
      during the initial postoperative period. Therefore, information conveyed by the 
      hepatic branch of the vagus can apparently lead to a conditioned feeding 
      response. This is evidence for a more subtle role of the liver in the control of 
      food intake than previously thought.
FAU - Langhans, W
AU  - Langhans W
AD  - Institut fur Veterinar-Physiologie, Universitat Zurich, Switzerland.
FAU - Kunz, U
AU  - Kunz U
FAU - Scharrer, E
AU  - Scharrer E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
SB  - IM
MH  - Animals
MH  - Arousal/*physiology
MH  - Avoidance Learning/*physiology
MH  - Conditioning, Classical/physiology
MH  - Eating/*physiology
MH  - Food Preferences/physiology
MH  - Liver/*innervation
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Satiety Response/physiology
MH  - Taste/*physiology
MH  - Vagotomy
MH  - Vagus Nerve/*physiology
EDAT- 1989/10/01 00:00
MHDA- 1989/10/01 00:01
CRDT- 1989/10/01 00:00
PHST- 1989/10/01 00:00 [pubmed]
PHST- 1989/10/01 00:01 [medline]
PHST- 1989/10/01 00:00 [entrez]
AID - 0031-9384(89)90350-8 [pii]
AID - 10.1016/0031-9384(89)90350-8 [doi]
PST - ppublish
SO  - Physiol Behav. 1989 Oct;46(4):671-8. doi: 10.1016/0031-9384(89)90350-8.