PMID- 26024953
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20181113
IS  - 1573-7322 (Electronic)
IS  - 1382-4147 (Linking)
VI  - 20
IP  - 5
DP  - 2015 Sep
TI  - Cardiac stem cell therapy: Have we put too much hype in which cell type to use?
PG  - 613-9
LID - 10.1007/s10741-015-9494-7 [doi]
AB  - Injection of various stem cells has been tested with the hopes of improving 
      cardiac function after a myocardial infarction (MI). However, there is continued 
      controversy as to which cell type is best for repair. Due to technical 
      differences in cell isolation, processing, delivery, and cardiac functional 
      assessment by various investigators, it has been difficult to directly compare 
      the results of different cells. Using same techniques to evaluate the efficacy of 
      different cell types, we have separately delivered bone marrow cells (BMCs), 
      cardiospheres (CSs), CS-derived Sca-1(+)/CD45(-) cells, human embryonic stem 
      cell-derived cardiomyocytes, and BMC extract into infarcted murine myocardium and 
      found that all of these treatments reduce infarct size and improve cardiac 
      function post-MI similarly without one regimen being superior to another. The 
      beneficial effects appear to be via paracrine influences. Different progenitors 
      lead to improved cardiac function post-MI, but it is premature to hype any 
      specific cell type at this time.
FAU - Ye, Jianqin
AU  - Ye J
AD  - Division of Cardiology, Department of Medicine, University of California, San 
      Francisco, CA, 94143, USA.
FAU - Yeghiazarians, Yerem
AU  - Yeghiazarians Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Heart Fail Rev
JT  - Heart failure reviews
JID - 9612481
SB  - IM
MH  - Animals
MH  - Bone Marrow Transplantation/*methods
MH  - Humans
MH  - Mice
MH  - *Myocardial Infarction/metabolism/therapy
MH  - Myocytes, Cardiac/*physiology
MH  - Stem Cell Transplantation/*methods
MH  - *Stem Cells/classification/metabolism
MH  - Treatment Outcome
EDAT- 2015/05/31 06:00
MHDA- 2016/05/10 06:00
CRDT- 2015/05/31 06:00
PHST- 2015/05/31 06:00 [entrez]
PHST- 2015/05/31 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
AID - 10.1007/s10741-015-9494-7 [doi]
PST - ppublish
SO  - Heart Fail Rev. 2015 Sep;20(5):613-9. doi: 10.1007/s10741-015-9494-7.