PMID- 26025696
OWN - NLM
STAT- MEDLINE
DCOM- 20160111
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 109
IP  - 1
DP  - 2015 Jul
TI  - Genotype screening of APLN rs3115757 variant in Egyptian women population reveals 
      an association with obesity and insulin resistance.
PG  - 40-7
LID - S0168-8227(15)00246-6 [pii]
LID - 10.1016/j.diabres.2015.05.016 [doi]
AB  - AIMS: Apelin is one of adipokines that plays a pivotal role in energy metabolism, 
      insulin sensitivity and vascular integrity. A definite genetic variant of apelin 
      gene (APLN), rs3115757, was recently introduced to potentially influence apelin 
      expression in adipocytes. The aim of our study was to explore the sights of a 
      potential association of this functional variant with obesity traits, insulin 
      resistance indices as well as type 2 diabetes mellitus (T2DM) prevalence. 
      METHODS: Genotype screening for rs3115757 variant in 151 Egyptian female samples 
      was conducted. Fasting levels of serum insulin and lipid profile, in addition to 
      plasma glucose were measured. Cochran-Armitage trend test was used to decide the 
      risk allele and evaluate the association between the candidate variant and 
      obesity using a case-control design. RESULTS: The homozygous G risk allele 
      carriers showed higher values of body mass index (BMI) and waist circumference 
      (P=0.001,0.02, respectively) as compared to CC or CG genotypes. As for GG 
      genotype carriers, the risk of developing morbid obesity in lean subjects, 
      (BMI<25), is twelve times the risk in subjects carrying other genotypes 
      (OR=12.09, 95% CI: 1.4, 104.8, P=0.024). On the other hand, GG carriers are shown 
      to be more resistant to insulin. Significantly after correction for BMI and age 
      effects, GG genotype carriers showed 14% and 41% increment in insulin level and 
      resistance (OR=1.14, 95% CI: 1.06, 1.23, P=0.001), (OR=1.42, 95% CI: 1.19, 1.70, 
      P<0.001), respectively. CONCLUSION: These results suggest a prospective role 
      mediated by this variant in mounting obesity disorders and as significant as 
      insulin resistance complications.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Aboouf, Mostafa A
AU  - Aboouf MA
AD  - Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, 
      Cairo, Egypt.
FAU - Hamdy, Nadia M
AU  - Hamdy NM
AD  - Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, 
      Cairo, Egypt.
FAU - Amin, Ashraf I
AU  - Amin AI
AD  - Clinical Pathology and Laboratory Department, National Institute of Diabetes and 
      Endocrinology (NIDE), Cairo, Egypt.
FAU - El-Mesallamy, Hala O
AU  - El-Mesallamy HO
AD  - Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, 
      Cairo, Egypt. Electronic address: hala.elmesallamy@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20150512
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (APLN protein, human)
RN  - 0 (Adipokines)
RN  - 0 (Apelin)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Adipokines
MH  - Adolescent
MH  - Adult
MH  - Apelin
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - DNA Mutational Analysis
MH  - Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Egypt/epidemiology
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Testing
MH  - Genotype
MH  - Humans
MH  - Insulin Resistance/*genetics
MH  - Intercellular Signaling Peptides and Proteins/*genetics
MH  - Middle Aged
MH  - Obesity/epidemiology/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Waist Circumference/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Apelin
OT  - Genotyping
OT  - Insulin resistance
OT  - Metabolic syndrome
OT  - Obesity
OT  - T2DM
EDAT- 2015/05/31 06:00
MHDA- 2016/01/12 06:00
CRDT- 2015/05/31 06:00
PHST- 2014/12/26 00:00 [received]
PHST- 2015/04/02 00:00 [revised]
PHST- 2015/05/01 00:00 [accepted]
PHST- 2015/05/31 06:00 [entrez]
PHST- 2015/05/31 06:00 [pubmed]
PHST- 2016/01/12 06:00 [medline]
AID - S0168-8227(15)00246-6 [pii]
AID - 10.1016/j.diabres.2015.05.016 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2015 Jul;109(1):40-7. doi: 
      10.1016/j.diabres.2015.05.016. Epub 2015 May 12.