PMID- 26026780
OWN - NLM
STAT- MEDLINE
DCOM- 20160303
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 109
IP  - 2
DP  - 2015 Aug
TI  - Retrospective analysis of the relationship between elevated plasma levels of 
      TXNIP and carotid intima-media thickness in subjects with impaired glucose 
      tolerance and early Type 2 diabetes mellitus.
PG  - 372-7
LID - S0168-8227(15)00258-2 [pii]
LID - 10.1016/j.diabres.2015.05.028 [doi]
AB  - AIMS: Accelerated atherosclerosis is the major cause of mortality in diabetic 
      patients and increased oxidative stress probably plays an important role in its 
      development. The aim of our study was to evaluate the relationship between 
      thioredoxin-interacting protein (TXNIP) as an oxidative stress parameter and 
      carotid artery intima-media thickness (CIMT) as an indicator of atherosclerosis 
      in patients with early-state diabetes and impaired glucose tolerance. METHODS: 
      The study was a retrospective analysis of 90 patients with impaired glucose 
      regulation (IGR), 80 patients with early Type 2 diabetes mellitus (T2DM), and 80 
      subjects with normal glucose tolerance (NGT) as the control group. It was 
      conducted at the endocrine out-patient clinic and hospital department of Cangzhou 
      Central Hospital (Cangzhou, China) from June 2012 to Oct. 2013. Plasma TXNIP was 
      measured to evaluate the level of oxidative stress. CIMT was assessed by carotid 
      artery ultrasonography. Soluble vascular cell adhesion molecule-1 (sVCAM-1), a 
      risk indicator for endothelial dysfunction, was also measured. RESULTS: Compared 
      to the NGT control, patients with IGR showed significantly higher plasma levels 
      of TXNIP (P<0.05). Compared to the IGR group, patients with T2DM also had 
      significantly higher plasma levels of TXNIP (P<0.05). CIMT was significantly 
      higher in the subjects with abnormal glucose metabolism than in the NGT group 
      (P<0.05). CIMT showed positive correlations with both TXNIP and sVCAM-1 levels (r 
      = 0.56 and r = 0.49, respectively, both P<0.01). CONCLUSIONS: The present study 
      showed that plasma levels of TXNIP may be a useful predictor of subclinical 
      atherosclerosis in Type 2 diabetic patients.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhao, Yongcai
AU  - Zhao Y
AD  - Department of Endocrinology, CangZhou Central Hospital, Cangzhou, China. 
      Electronic address: zyc_78615@aliyun.com.
FAU - Li, Xinsheng
AU  - Li X
AD  - Department of Endocrinology, CangZhou Central Hospital, Cangzhou, China.
FAU - Tang, Shiling
AU  - Tang S
AD  - Department of Endocrinology, CangZhou Central Hospital, Cangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20150515
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
RN  - 0 (Carrier Proteins)
RN  - 0 (TXNIP protein, human)
RN  - 52500-60-4 (Thioredoxins)
SB  - IM
MH  - Atherosclerosis/*blood/complications/diagnostic imaging
MH  - Blood Glucose/*metabolism
MH  - Carotid Artery, Common/*diagnostic imaging
MH  - *Carotid Intima-Media Thickness
MH  - Carrier Proteins/*blood
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Glucose Intolerance/*blood/complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Thioredoxins
OTO - NOTNLM
OT  - Carotid intima-media thickness
OT  - Glucose metabolism disorders
OT  - Glucose tolerance test
OT  - TXNIP
OT  - Type 2 diabetes mellitus
OT  - Ultrasonography
EDAT- 2015/06/01 06:00
MHDA- 2016/03/05 06:00
CRDT- 2015/06/01 06:00
PHST- 2014/10/30 00:00 [received]
PHST- 2015/03/03 00:00 [revised]
PHST- 2015/05/02 00:00 [accepted]
PHST- 2015/06/01 06:00 [entrez]
PHST- 2015/06/01 06:00 [pubmed]
PHST- 2016/03/05 06:00 [medline]
AID - S0168-8227(15)00258-2 [pii]
AID - 10.1016/j.diabres.2015.05.028 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2015 Aug;109(2):372-7. doi: 
      10.1016/j.diabres.2015.05.028. Epub 2015 May 15.