PMID- 26027495
OWN - NLM
STAT- MEDLINE
DCOM- 20160901
LR  - 20181113
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 298
IP  - Pt A
DP  - 2016 Feb 1
TI  - Global and gene-specific DNA methylation alterations in the adolescent amygdala 
      and hippocampus in an animal model of caregiver maltreatment.
PG  - 55-61
LID - S0166-4328(15)00357-5 [pii]
LID - 10.1016/j.bbr.2015.05.028 [doi]
AB  - Epigenetic mechanisms such as DNA methylation are part of an emerging story on 
      how early-life experiences can alter behavioral trajectories and lead to the 
      development of disease and psychological disorders. Previous work from our 
      laboratory has demonstrated alterations in methylation of DNA associated with the 
      brain-derived neurotrophic factor (bdnf) gene within the amygdala and hippocampus 
      of infant and adult rats that were repeatedly exposed to caregiver maltreatment 
      outside the home cage during their first week of life. In the current study we 
      examine changes in global levels of DNA methylation (5-mC) and hydroxymethylation 
      (5-hmC), as well as gene-specific changes in methylation patterns of the 
      candidate gene bdnf (at exons I and IV) within the adolescent amygdala and 
      hippocampus resulting from exposure to maltreatment. While adolescent females 
      exposed to maltreatment showed no significant alterations in global 5-mC or 5-hmC 
      levels, examination of bdnf DNA methylation revealed that maltreated females had 
      greater methylation of exon IV DNA in the amygdala and ventral hippocampus. While 
      adolescent males exposed to maltreatment showed no significant alterations in 
      bdnf DNA methylation, maltreated males had significantly higher 5-mC levels in 
      the dorsal hippocampus and lower 5-hmC levels in the amygdala. These findings 
      demonstrate that the effects of the early caregiving environment are detectable 
      in the adolescent brain at the level of the epigenome, with brain-region specific 
      and sexually-dimorphic epigenetic consequences that could have relevance to 
      adolescent mental health and behavior.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Doherty, Tiffany S
AU  - Doherty TS
AD  - Department of Psychological and Brain Sciences, University of Delaware, 108 Wolf 
      Hall, Newark, DE 19716, United States.
FAU - Forster, Amy
AU  - Forster A
AD  - Department of Psychological and Brain Sciences, University of Delaware, 108 Wolf 
      Hall, Newark, DE 19716, United States.
FAU - Roth, Tania L
AU  - Roth TL
AD  - Department of Psychological and Brain Sciences, University of Delaware, 108 Wolf 
      Hall, Newark, DE 19716, United States. Electronic address: troth@psych.udel.edu.
LA  - eng
GR  - P20 GM103446/GM/NIGMS NIH HHS/United States
GR  - P20 GM103653/GM/NIGMS NIH HHS/United States
GR  - 1P20GM103653-01A1/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150528
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
EIN - Behav Brain Res. 2016 Oct 1;312:431. PMID: 27372518
MH  - Amygdala/growth & development/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Child
MH  - Child Abuse
MH  - *DNA Methylation
MH  - Disease Models, Animal
MH  - Epigenesis, Genetic
MH  - Exons
MH  - Female
MH  - Hippocampus/growth & development/*metabolism
MH  - Housing, Animal
MH  - Humans
MH  - Male
MH  - *Maternal Behavior/psychology
MH  - Rats, Long-Evans
MH  - Sex Characteristics
MH  - Stress, Psychological/*metabolism
PMC - PMC4662928
MID - NIHMS695211
OTO - NOTNLM
OT  - Adolescence
OT  - Bdnf gene
OT  - DNA hydroxymethylation
OT  - DNA methylation
OT  - Early-life stress
EDAT- 2015/06/02 06:00
MHDA- 2016/09/02 06:00
PMCR- 2017/02/01
CRDT- 2015/06/02 06:00
PHST- 2014/12/19 00:00 [received]
PHST- 2015/04/03 00:00 [revised]
PHST- 2015/05/15 00:00 [accepted]
PHST- 2015/06/02 06:00 [entrez]
PHST- 2015/06/02 06:00 [pubmed]
PHST- 2016/09/02 06:00 [medline]
PHST- 2017/02/01 00:00 [pmc-release]
AID - S0166-4328(15)00357-5 [pii]
AID - 10.1016/j.bbr.2015.05.028 [doi]
PST - ppublish
SO  - Behav Brain Res. 2016 Feb 1;298(Pt A):55-61. doi: 10.1016/j.bbr.2015.05.028. Epub 
      2015 May 28.