PMID- 26029693
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150601
LR  - 20201001
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 3
DP  - 2015
TI  - Generation of skeletal muscle cells from pluripotent stem cells: advances and 
      challenges.
PG  - 29
LID - 10.3389/fcell.2015.00029 [doi]
LID - 29
AB  - Human pluripotent stem cells (hPSCs) possess unlimited proliferative potential 
      while maintaining the ability to differentiate into any cell type including 
      skeletal muscle cells (SMCs). hPSCs are amenable to genetic editing and can be 
      derived from patient somatic cells, and thus represent a promising option for 
      cell therapies for the treatment of degenerative diseases such as muscular 
      dystrophies. There are unresolved challenges however associated with the 
      derivation and scale-up of hPSCs and generation of differentiated cells in large 
      quantity and high purity. Reported myogenic differentiation protocols are long, 
      require cell sorting and/or rely on ectopic expression of myogenic master 
      regulators. More recent advances have been made with the application of small 
      molecules to enhance the myogenic differentiation efficiency and the 
      identification of more selective markers for the enrichment of myogenic 
      progenitors with enhanced regenerative potential. Here we review the field of 
      myogenic differentiation and highlight areas requiring further research.
FAU - Abujarour, Ramzey
AU  - Abujarour R
AD  - Fate Therapeutics Inc. San Diego, CA, USA.
FAU - Valamehr, Bahram
AU  - Valamehr B
AD  - Fate Therapeutics Inc. San Diego, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150513
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC4429629
OTO - NOTNLM
OT  - IPSC
OT  - MyoD
OT  - myogenic differentiation
OT  - pax7
OT  - pluripotent
OT  - satellite cells
OT  - skeletal muscle
OT  - skeletal muscle cells
EDAT- 2015/06/02 06:00
MHDA- 2015/06/02 06:01
PMCR- 2015/01/01
CRDT- 2015/06/02 06:00
PHST- 2015/03/11 00:00 [received]
PHST- 2015/04/28 00:00 [accepted]
PHST- 2015/06/02 06:00 [entrez]
PHST- 2015/06/02 06:00 [pubmed]
PHST- 2015/06/02 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fcell.2015.00029 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2015 May 13;3:29. doi: 10.3389/fcell.2015.00029. eCollection 
      2015.